Effects of pinealectomy and exogenous melatonin on immunohistochemical ghrelin staining of arcuate nucleus and serum ghrelin leves in the rat

Neuroscience Letters

Volumn 410, Issue 2, 2006, Pages 132-136

  Canpolat, Sinan ^a   Aydin, Mehmet ^a   Yasar, Abdullah ^a   Colakoglu, Neriman ^a   Yilmaz, Bayram ^a   Kelestimur, Haluk ^a  

^a FIRAT UNIVERSITY   (Turkey)

Author keywords

Arcuate nucleus; Ghrelin; Immunohistochemistry; Melatonin; Pinealectomy

Indexed keywords

GHRELIN; MELATONIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARCUATE NUCLEUS; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG EFFECT; HORMONAL REGULATION; HORMONE BLOOD LEVEL; HORMONE SYNTHESIS; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; MALE; NEUROCHEMISTRY; NONHUMAN; PINEAL BODY; PINEALECTOMY; PRIORITY JOURNAL; RAT; RAT STRAIN; STATISTICAL SIGNIFICANCE;

ANALYSIS OF VARIANCE; ANIMALS; ARCUATE NUCLEUS; BODY WEIGHT; EATING; IMMUNOHISTOCHEMISTRY; MALE; MELATONIN; PEPTIDE HORMONES; PINEAL GLAND; RATS; RATS, SPRAGUE-DAWLEY;

EID: 33750705588     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2006.09.071     Document Type: Article

References (25)

1. Asakawa A., Inui A., Kaga T., Yuzuriha H., Nagata T., Ueno N., Makino S., Fujimiya M., Niijima A., Fujino M.A., and Kasuga M. Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin. Gastroenterology 120 (2001) 337-345
2. Attanasio A., Borrelli F., and Gupta D. Circadian rhythms in serum melatonin from infancy to adolescence. J. Clin. Endocrinol. Metab. 61 (1985) 388-390
3. Banks W.A., Kastin A.J., Hunag W., Jaspan J.P., and Maness L.M. Leptin enters the brain by a saturable system independent of insulin. Peptides 17 (1997) 305-311
4. Baskin D.G., Schwartz M.W., Seeley R.J., Woods S.C., Porte D., Breininger J.F., Jonak Z., Schaefer J., Krouse M., Burghdat C., Campfield L.A., Burn P., and Kochan J.P. Leptin receptor long-form splice-variant protein expression in neuron cell bodies of the brain and co-localization with neuropeptide Y mRNA in the arcuate nucleus. J. Histochem. Cytochem. 47 (1999) 353-362
5. Canpolat S., Sandal S., Yilmaz B., Yasar A., Kutlu S., Baydas G., and Kelestimur H. Effects of pinealectomy and exogenous melatonin on serum leptin levels in male rat. Eur. J. Pharmacol. 428 (2001) 145-148
6. Chen H.Y., Trumbauer M.E., Chen A.S., Weingarth D.T., Adams J.R., Frazier E.G., Shen Z., Marsh D.J., Feighner S.D., Guan X.M., Ye Z., Nargund R.P., Smith R.G., Van der Ploeg L.H., Howard A.D., MacNeil D.J., and Qian S. Orexigenic action of peripheral ghrelin is mediated by neuropeptide Y and agouti-related protein. Endocrinology 145 (2004) 2607-2612
7. Date Y., Murakami N., Kojima M., Kuroiwa T., Matsukura S., Kangawa K., and Nakazato M. Central effects of a novel acylated peptide, ghrelin, on growth hormone release in rats. Biochem. Biophys. Res. Commun. 275 (2000) 477-480
8. Diaz E., Debeljuk L., Arce A., Esquifino A.I., and Diaz B. Prenatal melatonin exposure affects luteinizing hormone and hypothalamic and striatal neuropeptide Y in the male rat offspring. Neurosci. Lett. 292 (2000) 143-146
9. Elmquist J.K., Elias C.F., and Saper C.B. From lesions to leptin: hypothalamic control of food intake and body weight. Neuron 22 (1999) 221-232
10. Fernández-Fernández R., Navarro V.M., Barreiro M.L., Vigo E.M., Tovar S., Sirotkin A.V., Casanueva F.F., Aguilar E., Dieguez C., Pinilla L., and Tena-Sempere M. Effects of chronic hyperghrelinemia on puberty onset and pregnancy outcome in the rat. Endocrinology 146 (2005) 3018-3025
11. Forsling M.L., Wheeler M.J., and Williams A.J. The effect of melatonin administration on pituitary hormone secretion in man. Clin. Endocrinol. (Oxf.) 51 (1999) 637-642
12. Hosoda H., Kojima M., Mizushima T., Shimizu S., and Kangawa K. Structural divergence of human ghrelin. Identification of multiple ghrelin-derived molecules produced by post-translational processing. J. Biol. Chem. 278 (2003) 64-70
13. Huether G., Poeggeler B., Reimer A., and George A. Effect of tryptophan administration on circulating melatonin levels in chicks and rats: evidence for stimulation of melatonin synthesis and release in the gastrointestinal tract. Life Sci. 51 (1992) 945-953
14. Kojima M., Hosoda H., Date Y., Nakazato M., Matsuo H., and Kangawa K. Ghrelin is a growth-hormone-releasing peptide from stomach. Nature 402 (1999) 656-660
15. Kus I., Sarsilmaz M., Colakoglu N., Kukne A., Ozen O.A., Yilmaz B., and Kelestimur H. Pinealectomy increases and exogenous melatonin decreases leptin production in rat anterior pituitary cells: an immunohistochemical study. Physiol. Res. 53 (2004) 403-408
16. Lu S., Guan J.L., Wang Q.P., Uehara K., Yamada S., Goto N., Date Y., Nakazato M., Kojima M., Kangawa K., and Shioda S. Immunocytochemical observation of ghrelin containing neurons in the rat arcuate nucleus. Neurosci. Lett. 321 (2002) 157-160
17. Mercer J.G., Hoggard N., Williams L.M., Lawrence C.B., Hannah L.T., Morgan P.J., and Trayhurn P. Coexpression of leptin receptor and preproneuropeptide Y mRNA in ARC of mouse hypothalamus. J. Neuroendocrinol. 8 (1996) 733-735
18. Mustonen A.M., Nieminen P., and Hyvarinen H. Preliminary evidence that pharmacologic melatonin treatment decreases rat ghrelin levels. Endocrine 16 (2001) 43-46
19. Nakazato M., Murakami N., Date Y., Kojima M., Matsuo H., Kangawa K., and Matsukura S. A role for ghrelin in the central regulation of feeding. Nature 409 (2001) 194-198
20. Tannenbaum G.S., Lapointe M., Beaudet A., and Howard A.D. Expression of growth hormone secretagogue-receptors by growth hormone-releasing hormone neurons in the mediobasal hypothalamus. Endocrinology 139 (1998) 4420-4423
21. Waldhauser F., Boepple P.A., Schemper M., Mansfield M.J., and Crowley Jr. W.F. Serum melatonin in central precocious puberty is lower than in age-matched prepubertal children. J. Clin. Endocrinol. Metab. 73 (1991) 793-796
22. Waldhauser F., Frisch H., Waldhauser M., Weiszenbacher G., Zeitlhuber U., and Wurtman R.J. Fall in nocturnal serum melatonin during prepuberty and pubescence. Lancet 18 (1985) 362-365
23. Wang Q., Bing C., Al-Barazanji K., Mossakowaska D.E., Wang X.M., McBay D.L., Neville W.A., Taddayon M., Pickavance L., Dryden S., Thomas M.E., McHale M.T., Gloyer I.S., Wilson S., Buckingham R., Arch J.R., Trayhurn P., and Williams G. Interactions between leptin and hypothalamic neuropeptide Y neurons in the control of food intake and energy homeostasis in the rat. Diabetes 46 (1997) 335-341
24. Willensen M.G., Kristensen P., and Romer J. Co-localizationof growth hormone secreagogue receptor and NPYmRNA in the arcuate nucleus of the rat. Neuroendocrinology 70 (1999) 306-316
25. Wren A.M., Small C.J., Ward H.L., Murphy K.G., Dakin C.L., Taheri S., Kennedy A.R., Roberts G.H., Morgan D.G., Ghatei M.A., and Bloom S.R. The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion. Endocrinology 141 (2000) 4325-4328