Numerical analysis of gas and micro-particle interactions in a hand-held shock-tube device

Biomedical Microdevices

Volumn 8, Issue 4, 2006, Pages 341-351

  Liu, Yi ^a   Kendall, M A F ^b  

^a JIANGNAN UNIVERSITY   (China)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Biolistic; Drug delivery; Gene gun; Micro particle; Skin; Transient; Transonic; Vaccine delivery

Indexed keywords

BIOLOGICAL MEMBRANES; COMPUTER SIMULATION; DRAG; GAS DYNAMICS; GENES; JETS; SHOCK TUBES; SKIN; STATISTICAL METHODS; VACCINES;

BIOMOLECULES; CONTOURED SHOCK TUBE; GAS-PARTICLE INTERACTION; GENE GUN; VELOCITY DISTRIBUTIONS;

CONTROLLED DRUG DELIVERY;

POLYSTYRENE;

ARTICLE; CALCULATION; COMPUTER PROGRAM; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG DELIVERY SYSTEM; FLOW RATE; GAS ANALYSIS; GAS FLOW; GENE GUN; MATHEMATICAL COMPUTING; MOLECULAR DYNAMICS; PARTICULATE MATTER; PORTABLE EQUIPMENT; PREDICTION; PRESSURE MEASUREMENT; PRIORITY JOURNAL; SIMULATION; STATISTICAL ANALYSIS; VALIDATION PROCESS;

ADMINISTRATION, CUTANEOUS; BIOLISTICS; GASES; MICROSPHERES; POLYSTYRENES;

KURIA;

EID: 33750705307     PISSN: 13872176     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10544-006-9596-z     Document Type: Article

References (27)

1. T.M. Klein, E.D. Wolf, R. Wu, and J.C. Sanford, High-velocity microprojectiles for delivering nucleic acids into living cells. Nature 327, 70-73 (1987).
2. D. Chen, Y. Maa, and J. R. Haynes, Needle-free epidermal powder immunization. Expert Rev. Vaccines 1(3), 89-100 (2002).
3. V.B. Vassilev, L.H.V.G. Gil, R.O. Donis, Microparticle-mediated RNA immunization against bovine viral diarrhea virus. Vaccine. 19(15-16), 2012-2019 (2001).
4. J. Dileo, T.E. Miller Jr., and L. Huang, Gene transfer to subdermal tissues via a new gene gun design. Human Gene Therapy 14(1), 79-87 (2003).
5. C. Trimble, C. Lin, C. Hung, S. Pai, J. Juang, L. He, M. Gillison, D. Pardoll, L. Wu, and T.C. Wu, Comparison of the CD8+ T cell responses and antitumor effects generated by DNA vaccine administered through gene gun, biojector, and syringe. Vaccine 21(25-26), 4036-4042 (2003).
6. M.A.F. Kendall, T.J. Mitchell, and P. Wrighton-Smith, Intradermal ballistic delivery of micro-particles into excised human skin for drug and vaccine applications. Journal of Biomechanics 37(11), 1733-1741 (2004).
7. N.J. Quinlan, M.A.F. Kendall, B.J. Bellhouse, R.W. Ainsworth, Investigations of gas and particle dynamics in first generation needle-free drug delivery devices. International Journal on Shock Waves 10(6),395-404 (2001).
8. M.A.F. Kendall, N.J. Quinlan, S.J. Thorpe, R.W. Ainsworth, and B.J. Bellhouse, Measurements of the gas and particle flow within a converging-diverging nozzle for high speed powdered vaccine and drug delivery. Experiments in Fluids 37, 128-136 (2004).
9. Y. Liu and M.A.F. Kendall, Numerical study of a transient gas and particle flow in a high-speed needle-free ballistic particulate vaccine delivery system. Journal of Mechanics in Medicine and Biology. 4 (4), 559-578 (2004).
10. M.A.F. Kendall and G.L. Brown, WIPO Patent PCT/GB00/02257 Needleless Syringe. Filed June 2000, National Phase.
11. M.A.F. Kendall and G.L. Brown, and B.J. Bellhouse, Needle-free, Dermal Delivery of Dry Powdered Drugs using Contoured Shock Tubes. American Institute of Aeronautics and Astronautics. Fluids 2000, Denver, USA (2000).
12. Y. Liu, M.A.F. Kendall, N.K. Truong, and B.J. Bellhouse, Numerical and experimental analysis of a high speed needle-free powdered vaccines delivery device. AIAA-2002-2807, in Proc. 20th AIAA Applied Aerodynamics Conference, St. Louis, MO, USA (2002).
13. M.P. Hardy and M.A.F. Kendall, Mucosal deformation from an impinging transonic gas jet and the ballistic impact of microparticles. Physics in Medicine and Biology 50, 4567-4580 (2005).
14. M.A.F. Kendall, The delivery of particulate vaccines and drugs to human skin with a practical, hand-held shock tube-based system. Shock Waves Journal 12 (1), 22-30 (2002).
15. M. Marrion, Y. Liu, and M.A.F. Kendall, The gas-dynamic effects of a hemisphere-cylinder obstacle in a shock-tube driver. Experiments in Fluids 38, 319-327 (2005).
16. Y. Liu, M. Marrion, and M.A.F. Kendall, Numerical investigation of a hemisphere-cylinder obstacle in a shock-tube driver. Proc. 25th Int. Symp. on Shock Waves, Bangalore, India (2005).
17. N.K. Truong, Particle fluid interactions in Contoured Shock Tube system for needle-free vaccine delivery. D. Phil. Thesis, University of Oxford, United Kingdom (2005).
18. M.A.F. Kendall, S. Rishworth, F.V. Carter, and T.J. Mitchell, The effects of relative humidity and ambient temperature on the ballistic delivery of micro-particles into excised porcine skin. Journal of Investigative Dermatology 122 (3), 739-746 (2004).
19. W.J. Mulholland, M.A.F. Kendall, N. White, and B.J. Bellhouse, Characterization of powdered epidermal vaccine delivery with multiphoton microscopy. Physics in Medicine and Biology 49, 5043-5058 (2004).
20. T.J. Mitchell, M.A.F. Kendall, B.J. Bellhouse, A ballistic study of micro-particle penetration to the oral Mucosa. International Journal of Impact Engineering 28, 581-599 (2003).
21. P.A. Raju, N.K Truong, M.A.F. Kendall, (in press) Assessment of epidermal cell viability by Near Infra-Red Multi-photon Microscopy following ballistic delivery of gold micro-particles. Vaccines 24(21), 4644-4647 (2006).
22. C.E. Smith, The starting process in a hypersonic nozzle. Journal of Fluid Mechanics 24, 625-641 (1966).
23. R.F. Chisnell, The motion of a shock wave in a channel, with applications to cylindrical and spherical shock waves. Journal Fluid Mechanics 2, 286-298 (1957).
24. C.B. Henderson, Drag coefficient of spheres in continuum and rarefied flows. AIAA Journal 14(6), 707-708 (1976).
25. O. Igra and K. Takayama, Shock tube study of the drag coefficient of a sphere in a non-stationary flow. Proc R. Soc. Lond. A 442, 231-2467 (1993).
26. J. Kurian and H.K. Das, Studies of shock wave propagation in gas-particle mixtures, Proc. 21st Int. Symp. on Shock Waves, Great Keppel Island, Australia (1997).
27. Fluent user's guide volume, Fluent inc., Lebanon, NH 03766, USA, also see http://www.fluent.com/.