Genotoxicity testing of a Salacia oblonga extract

Food and Chemical Toxicology

Volumn 44, Issue 11, 2006, Pages 1868-1874

  Flammang, A M ^a   Erexson, G L ^b   Mecchi, M S ^b   Murli, H ^b  

^a ABBOTT LABORATORIES   (United States)

^b Department of Environmental Air Quality   (United States)

Author keywords

Glucosidase inhibitor; Chromosomal aberration assay; Mouse micronucleus assay; Reverse mutation assay; Safety; Salacia oblonga; Toxicology

Indexed keywords

ALPHA GLUCOSIDASE; FOOD ADDITIVE; GLUCOSE; PLANT EXTRACT; SALACIA OBLONGATA EXTRACT; ENZYME INHIBITOR; MUTAGENIC AGENT; RIBOSOMAL PROTEIN S9; RIBOSOME PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASSAY; AYURVEDA; BLOOD GLUCOSE MONITORING; CHROMOSOMAL ABERRATION ASSAY; CHROMOSOME ABERRATION; CONTROLLED STUDY; DIABETES MELLITUS; ENZYME INHIBITION; GENOTOXICITY; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN CELL; LYMPHOCYTE; MALE; MICRONUCLEUS TEST; MOUSE; NONHUMAN; PATIENT SAFETY; PLANT ROOT; RAT; REPRODUCIBILITY; REVERSE MUTATION ASSAY; REVERTANT; SALACIA; SALACIA OBLONGATA; ANIMAL; CHEMICALLY INDUCED DISORDER; CHEMISTRY; CLASSIFICATION; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; ESCHERICHIA COLI; GENETICS; MEDICINAL PLANT; METABOLISM; MICRONUCLEUS; MOUSE STRAIN; MUTAGEN TESTING; SALMONELLA TYPHIMURIUM; SPRAGUE DAWLEY RAT;

SALACIA OBLONGA;

ALPHA-GLUCOSIDASES; ANIMALS; CHROMOSOME ABERRATIONS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; ESCHERICHIA COLI; HUMANS; MALE; MEDICINE, AYURVEDIC; MICE; MICE, INBRED STRAINS; MICRONUCLEI, CHROMOSOME-DEFECTIVE; MUTAGENICITY TESTS; MUTAGENS; PLANT EXTRACTS; PLANTS, MEDICINAL; RATS; RATS, SPRAGUE-DAWLEY; RIBOSOMAL PROTEINS; SALACIA; SALMONELLA TYPHIMURIUM;

EID: 33750691704     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2006.06.005     Document Type: Article

References (16)

1. Ames B.N., McCann J., and Yamasaki E. Methods for detecting carcinogens and mutagens with the Salmonella/Mammalian-microsome mutagenicity test. Mutation Research 31 (1975) 347-364
2. Evans H.J. Chromosomal aberrations produced by ionizing radiation. International Review of Cytology 13 (1962) 221-321
3. Evans H.J. Cytological methods for detecting chemical mutagens. In: Hollaender A. (Ed). Chemical Mutagens: Principles and Methods for their Detection vol. 4 (1976), Plenum Press, New York and London 1-29
4. Galloway S.M., Aardema M.J., Ishidate Jr. M., Ivett J.L., Kirkland D.J., Morita T., Mosesso P., and Sofuni T. Report from working group on in vitro tests for chromosomal aberrations. Mutation Research 312 3 (1994) 241-261
5. Ghavami A., Johnston B.D., Jensen M.T., Svensson B., and Pinto B.M. Synthesis of nitrogen analogues of salacinol and their evaluation as glycosidase inhibitors. Journal of the American Chemical Society 123 (2001) 6268-6271
6. + reversion in Escherichia coli. Mutation Research 38 (1976) 3-32
7. Grover J.K., Yadav S., and Vats V. Medicinal plants of India with anti-diabetic potential. Journal of Ethnopharmacology 81 (2002) 81-100
8. Guidance for Industry and Review Staff, Recommended Approaches to Integration of Genetic Toxicology Study Results, US Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research (CDER), Pharmacology and Toxicology, January 2006, 5 pages.
9. Maron D.M., and Ames B.N. Revised methods for the Salmonella mutagenicity test. Mutation Research 113 (1983) 173-215
10. Matsuda H., Morikawa T., and Yoshikawa M. Antidiabetogenic constituents from several natural medicines. Pure and Applied Chemistry 74 (2002) 1301-1308
11. Matsuda H., Murakami T., Yashiro K., Yamahara J., and Yoshikawa M. Antidiabetic principles of natural medicines. IV. Aldose reductase and alpha-glucosidase inhibitors from the roots of Salacia oblonga wall. (Celastraceae): structure of a new friedelane-type triterpene, kotalagenin 16-acetate. Chemical and Pharmaceutical Bulletin 47 (1999) 1725-1729
12. Matsuda H., Yoshikawa M., Morikawa T., Tanabe G., and Muraoka O. Antidiabetic constituents from Salacia species. Journal of Traditional Medicine 22 (2005) 145-153
13. Miura T., Ichiki H., Hashimoto I., Iwamoto N., Kato M., Kubo M., et al. Antidiabetic activity of a xanthone compound, mangiferin. Phytomedicine 8 (2001) 85-87
14. Schmid W. The Micronucleus test for cytogenetic analysis. In: Hollaender A. (Ed). Chemical Mutagens: Principles and Methods for Their Detection vol. 4 (1976), Plenum 31-53
15. Thakur A.J., Berry K.J., and Mielke Jr. P.W. A FORTRAN program for testing trend and homogeneity in proportions. Computer Programs in Biomedicine 19 (1985) 229-233
16. Winer B.J. Statistical Principles in Experimental Design. second ed. (1971), McGraw-Hill, New York