Phenylephrine suppresses outward K+ currents in rat atrial myocytes

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 271, Issue 3 40-3, 1996, Pages

  Van Wagoner, David R ^a   Kirian, Margaret ^a   Lamorgese, Michelle ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Kv1.2; Kv1.5; Kv4.2; potassium channels; 1 adrenergic receptors

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR; DENDROTOXIN; DIACYLGLYCEROL; PHENYLEPHRINE; POTASSIUM CHANNEL;

ADOLESCENT; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; HEART ATRIUM; HEART MUSCLE CELL; KINETICS; MALE; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL;

EID: 33750687013     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.1996.271.3.h937     Document Type: Article

References (31)

1. Altschuld, R., L. Gibb, A. Zoretic, C. Hohl, F. Kruger, and G. P. Brierly. Calcium tolerance of isolated rat heart cells. J. Mol. Cell Cardiol. 12: 1383-1395, 1980.
2. + currents in rat ventricular myocytes. Proc. Natl. Acad. Sci. USA 85: 8756-8760, 1988.
3. + channel. Neuron 7: 471-483, 1991.
4. + channels. Circ. Res. 17: 361-369, 1995.
5. + currents in rat atrial myocytes. J. Gen. Physiol. 100: 1041-1067, 1992.
6. 1-adrenoceptors modulates the inwardly rectifying potassium currents of mammalian atrial myocytes. Pfluegers Arch. 421: 431-439, 1992.
7. + channels. J. Biol. Chem. 268: 27335-27344, 1993.
8. Dixon, J. E., and D. McKinnon. Quantitative analysis of potassium channel mRNA expression in atrial and ventricular muscle of rats. Circ. Res. 75: 252-260, 1994.
9. Ertl, R., U. Jahnel, H. Nawrath, E. Carmeliet, and J. Vereecke. Differential electrophysiological and inotropic effects of phenylephrine in atrial and ventricular heart muscle preparations from rats. Naunyn-Schmiedeberg's Arch. Pharmacol. 344: 574-581, 1991
10. 1-adrenoceptor stimulation in rat cardiac myocytes. Circ. Res. 71: 673-688, 1992.
11. 1-Adrenoceptors in myocardium: functional aspects and transmembrane signaling mechanisms. Physiol. Rev. 73: 469-487, 1993.
12. 1-adrenoceptors. Am. J. Physiol. 256 (Heart Circ. Physiol. 25): H1500-H1504, 1989.
13. + channel Kv1.2. Biochemistry 31: 12463-12468, 1992.
14. 1-adrenergic stimulation in rat cardiac myocytes exposed to hypoxia. J. Clin. Invest. 83: 1409-1413, 1989.
15. + channel (Kv1.5) by polyunsaturated fatty acids. Proc. Natl. Acad. Sci. USA 91: 1937-1944, 1994.
16. Korn, S. J., and R. Horn. Influence of sodium-calcium exchange on calcium current rundown and the duration of calcium dependent chloride currents in pituitary cells, studied with whole cell and perforated patch recording. J. Gen. Physiol. 94: 789-812, 1989.
17. 1-adrenergic receptor modulation of repolarization in canine Purkinje fibers. J. Cardiovasc. Electrophysiol. 5: 232-240, 1994.
18. + channel protein in explanted cardiac tissue. J. Clin. Invest. 96: 282-292, 1995.
19. Moravec, C. S., E. E. Reynolds, R. W. Stewart, and M. Bond. Endothelin is a positive inotropic agent in human and rat heart in vitro. Biochem. Biophys. Res. Commun. 159: 14-18, 1989.
20. Moravec, C. S., M. D. Schluchter, L. Paranandi, B. Czerska, R. W. Stewart, E. Rosenkranz, and M. Bond. Inotropic effects of angiotensin II on human cardiac muscle in vitro. Circulation 82: 1973-1984, 1990.
21. Muntz, K. H., S. L. Neyman, and J. C. Miller. Alterations in alpha(1)-adrenergic receptor-mediated phosphatidylinositol turnover in hypoxic cardiac myocytes. J. Mol. Cell Cardiol. 25: 1187-1202, 1993.
22. + channel by protein kinase C. Circ. Res. 75: 999-1005, 1995.
23. Paulmichl, M., P. Nasmith, R. Hellmiss, K. Reed, W. A. Boyle, J. M. Nerbonne, E. G. Peralta, and D. E. Clapham. Cloning and expression of a rat cardiac delayed rectifier potassium channel Proc. Natl. Acad. Sci. USA 88: 7892-7895, 1991.
24. Po, S., D. J. Snyders, R. Baker, M. M. Tamkun, and P. B. Bennett. Functional expression of an inactivating potassium channel cloned from human heart Circ. Res. 71: 732-736, 1992.
25. Prasad, M. R., and R. M. Jones. Enhanced membrane protein kinase C activity in myocardial ischemia. Basic Res. Cardiol. 87: 19-26, 1992.
26. + channel cloned from human heart. Mol. Pharmacol. 44: 1240-1245, 1993.
27. Ravens, U., X. L. Wang, and E. Wettwer. Alpha adrenoceptor stimulation reduces outward currents in rat ventricular myocytes. J. Pharmacol. Exp. Ther. 250: 364-370, 1989.
28. Schwertz, D. W., and J. Halverson. Changes in phosphoinositide-specific phospholipase C and phospholipase A2 activity in ischemic and reperfused rat heart. Basic Res. Cardiol. 87: 113-127, 1992.
29. Snyders, D. J., M. M. Tamkun, and P. B. Bennett. A rapidly activating and slowly inactivating potassium channel cloned from human heart. J. Gen. Physiol. 101: 513-543, 1993.
30. 1-adrenoceptors on transient outward current in isolated rat ventricular cells. Pfluegers Arch. 415: 575-581, 1990.
31. 1-adrenoceptor stimulation: a subtype-specific effect? J. Pharmacol. Exp. Ther. 259: 783-788, 1991.