Encephalopathy due to carnitine deficiency in an adult patient with gluten enteropathy

Clinical Neurology and Neurosurgery

Volumn 108, Issue 8, 2006, Pages 794-797

  Karakoç, Ebru ^a   Erdem, Sevim ^a   Sökmensüer, Cenk ^a   Kansu, Tülay ^a  

^a HACETTEPE UNIVERSITY   (Turkey)

Author keywords

Adult; Carnitine deficiency; Encephalopathy; Gluten enteropathy; Seizure; Treatment

Indexed keywords

CARNITINE; GLUTEN; LIPID;

ADULT; AMINO ACID BLOOD LEVEL; ANTIBODY BLOOD LEVEL; ARTICLE; BRAIN DISEASE; CARNITINE DEFICIENCY; CASE REPORT; CELIAC DISEASE; CLINICAL FEATURE; CONFUSION; DISEASE COURSE; DUODENUM BIOPSY; ELECTROENCEPHALOGRAPHY; FAT CONTENT; FECES ANALYSIS; FEVER; FOLLOW UP; GERIATRIC PATIENT; GLUTEN FREE DIET; HEADACHE; HUMAN; LIPID BLOOD LEVEL; MALE; SEIZURE; SUBSTITUTION THERAPY;

BIOPSY; BRAIN DISEASES, METABOLIC; CARNITINE; CELIAC DISEASE; DIAGNOSIS, DIFFERENTIAL; ELECTROENCEPHALOGRAPHY; EPILEPSY, ABSENCE; EPILEPSY, GENERALIZED; FOLLOW-UP STUDIES; GLIADIN; GLUTEN; HUMANS; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; INTESTINAL MUCOSA; LIPIDS; MALE; MIDDLE AGED;

EID: 33750686622     PISSN: 03038467     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clineuro.2005.10.012     Document Type: Article

References (21)

1. Winter S.C., and Buist N.R.M. The role of energy metabolism defects in cardiomyopathy: from inborn errors to ischemia. Am Heart J 139 (2000) 63-69
2. Schafer J., and Reichmann H. Subnormal carnitine levels and their correction in artificially fed patients from a neurological intensive care unit: a pilot study. J Neurol 237 (1990) 213-215
3. Angelini C., Trevisan C., Isaya G., Pegolo G., and Vergani L. Clinical varieties of carnitine and carnitine palmitoyl transferase deficiency. Clin Biochem 20 (1987) 1-7
4. Evans O.B., Parker C.C., Haas R.H., Naidu S., Moser H.W., and Bock H.O. Inborn errors of metabolism of the nervous system. In: Bradley W.G., Daroff R.B., Fenichel G.M., and Marsden C.D. (Eds). Neurology in clinical practice vol. 2 (2000), Butterworth-Heinemann, USA 1607-1608
5. Campos Y., Huertas R., Lorenzo G., Bautista J., Gutierrez E., Aparicio M., et al. Plasma carnitine insufficiency and effectiveness of l-carnitine therapy in patients with mitochondrial myopathy. Muscle Nerve 16 (1993) 150-153
6. Winter S.C., Szabo-Aczel S., Curry C.J., Hutchingson H.T., Hogue R., and Shug A. Plasma carnitine deficiency. Clinical observations in 51 pediatric patients. Am J Dis Child 141 (1987) 660-665
7. Di Donato S., Pelucchetti D., Rimoldi M., Mora M., Garavaglia B., and Finocchiaro G. Systemic carnitine deficiency: clinical, biochemical, and morphological cure with l-carnitine. Neurology 34 (1984) 157-162
8. Rico Corral M.A., de la Vega Vazquez J.M., Holgado Silva C., Aznar Martin A., and Zamora Madaria E. Carnitine deficiency myopathy: a case of late diagnosis. An Med Interna 19 (2002) 415-418
9. Di Mauro S., Trevisan C., and Hays A. Disorders of lipid metabolism in muscle. Muscle Nerve 3 (1980) 369-388
10. Bremer J., and Osmundsen H. Fatty acid metabolism and its regulation (1984), Elsevier Science Publishers, Amsterdam 113 pp.
11. Chalmers R.A., Roe C.R., Stacey T.E., and Hoppel C.L. Urinary excretion of l-carnitine and acylcarnitines by patients with disorders of organic acid metabolism: evidence for secondary insufficiency of l-carnitine. Pediatr Res 18 (1984) 1325-1328
12. Borum P.R. Carnitine in neonatal nutrition. J Child Neurol 10 (1995) S25-S31
13. Rebouche C.J., and Engel A.G. In vitro analysis of hepatic carnitine biosynthesis in human systemic carnitine deficiency. Clin Chim Acta 106 (1980) 295-300
14. Shintani S., Shiigai T., and Sugiyama N. Atypical presentation of carnitine palmitoyl transferase deficiency as status epilepticus. J Neurol Sci 129 (1995) 69-73
15. Lerner A., Gruener N., and Iancu T.C. Serum carnitine concentrations in celiac disease. Gut 34 (1993) 933-935
16. Bruzelius M., Liedholm L.J., and Hellblom M. Celiac disease can be associated with severe neurological symptoms. Analysis of gliadin antibodies should be considered in suspected cases. Lakartidningen 98 (2001) 3538-3542
17. Hagen E.M., Gjerde I.O., Vedeler C., and Hovdenak N. Neurological diseases associated with celiac disease. Tidsskr Nor Laegeforen 120 (2000) 439-442
18. Munchau A., and Vogel P. Reversible posterior encephalopathy possibly related to celiac disease: a vitamin-depleted brain?. Eur Neurol 41 (1999) 232-234
19. Tison F., Arne P., and Henry P. Myoclonus and adult celiac disease. J Neurol 236 (1989) 307-308
20. Kristoferitsch W., and Pointner H. Progressive cerebellar syndrome in adult celiac disease. J Neurol 234 (1987) 116-118
21. Hermaszewski R.A., Rigby S., and Dalgleish A.G. Coeliac disease presenting with cerebellar degeneration. Postgrad Med J 67 (1991) 1023-1024