Altered expression of hippocampal dentate granule neuron genes in a mouse model of human 22q11 deletion syndrome

Schizophrenia Research

Volumn 88, Issue 1-3, 2006, Pages 251-259

  Jurata, Linda W ^a   Gallagher, Paul ^a   Lemire, Andrew L ^a   Charles, Vinod ^a   Brockman, Jeffrey A ^a   Illingworth, Elizabeth Lindsay ^b   Altar, C Anthony ^a  

^a Psychiatric Genomics Inc   (United States)

^b TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

Author keywords

COMT; DiGeorge; Gene expression; Microarray; Schizophrenia; Velocardiofacial syndrome

Indexed keywords

CATECHOL METHYLTRANSFERASE; PROLINE DEHYDROGENASE; THIOREDOXIN REDUCTASE; UBIQUITIN PROTEIN LIGASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; CHROMOSOME 22Q; CHROMOSOME DELETION; CONTROLLED STUDY; DENTATE GYRUS; DIGEORGE SYNDROME; DNA MICROARRAY; ELECTRON TRANSPORT; GENE DELETION; GENE EXPRESSION; GENETIC VARIABILITY; HEMIZYGOSITY; HIPPOCAMPUS; LEARNING; MEMORY; MITOCHONDRIAL GENETICS; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PREPULSE INHIBITION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCHIZOPHRENIA; UNINDEXED SEQUENCE; VELOCARDIOFACIAL SYNDROME;

ANIMALS; CATECHOL O-METHYLTRANSFERASE; CHROMOSOME DELETION; CHROMOSOMES, HUMAN, PAIR 22; DENTATE GYRUS; DIGEORGE SYNDROME; DISEASE MODELS, ANIMAL; GENE LIBRARY; HIPPOCAMPUS; HUMANS; MICE; NEURONS; POINT MUTATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SCHIZOPHRENIA;

EID: 33750634178     PISSN: 09209964     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.schres.2006.07.017     Document Type: Article

References (31)

1. Altar C.A., Jurata L.W., Charles V., Lemire A., Liu P., Bukhman Y., Young T.A., Bullard J., Yokoe H., Webster M.J., Knable M.B., and Brockman J.A. Deficient hippocampal neuron expression of proteasome, ubiquitin, and mitochondrial genes in multiple schizophrenia cohorts. Biol. Psychiatry 58 2 (2005) 85-96
2. Baker K., Baldeweg T., Sivagnanasundaram S., Scambler P., and Skuse D. COMT Val108/158 Met modifies mismatch negativity and cognitive function in 22q11 deletion syndrome. Biol. Psychiatry 58 1 (2005) 23-31
3. Bassett A.S., Chow E.W., Husted J., Weksberg R., Caluseriu O., Webb G.D., and Gatzoulis M.A. Clinical features of 78 adults with 22q11 deletion syndrome. Am. J. Med. Genet. A. 138 4 (2005) 307-313
4. Egan M.F., Goldberg T.E., Kolachana B.S., Callicott J.H., Mazzanti C.M., Straub R.E., Goldman D., and Weinberger D.R. Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proc. Natl. Acad. Sci. U. S. A. 98 12 (2001) 6917-6922
5. Gogos J.A., Morgan M., Luine V., Santha M., Ogawa S., Pfaff D., and Karayiorgou M. Catechol-O-methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior. Proc. Natl. Acad. Sci. U. S. A. 95 17 (1998) 9991-9996
6. Gogos J.A., Santha M., Takacs Z., Beck K.D., Luine V., Lucas L.R., Nadler J.V., and Karayiorgou M. The gene encoding proline dehydrogenase modulates sensorimotor gating in mice. Nat. Genet. 21 4 (1999) 434-439
7. Gothelf D., Eliez S., Thompson T., Hinard C., Penniman L., Feinstein C., Kwon H., Jin S., Jo B., Antonarakis S.E., Morris M.A., and Reiss A.L. COMT genotype predicts longitudinal cognitive decline and psychosis in 22q11.2 deletion syndrome. Nat. Neurosci. 8 11 (2005) 1500-1502
8. Hayward D.C., Delaney S.J., Campbell H.D., Ghysen A., Benzer S., Kasprzak A.B., Cotsell J.N., Young I.G., and Miklos G.L. The sluggish-A gene of Drosophila melanogaster is expressed in the nervous system and encodes proline oxidase, a mitochondrial enzyme involved in glutamate biosynthesis. Proc. Natl. Acad. Sci. U. S. A. 90 7 (1993) 2979-2983
9. Huotari M., Gogos J.A., Karayiorgou M., Koponen O., Forsberg M., Raasmaja A., Hyttinen J., and Mannisto P.T. Brain catecholamine metabolism in catechol-O-methyltransferase (COMT)-deficient mice. Eur. J. Neurosci. 15 2 (2002) 246-256
10. Jerome L.A., and Papaioannou V.E. DiGeorge syndrome phenotype in mice mutant for the T-box gene, Tbx1. Nat. Genet. 27 3 (2001) 286-291
11. Jurata L.W., Bukhman Y.V., Charles V., Capriglione F., Bullard J., Lemire A.L., Mohammed A., Pham Q., Laeng P., Brockman J.A., and Altar C.A. Comparison of microarray-based mRNA profiling technologies for identification of psychiatric disease and drug signatures. J. Neurosci. Methods 138 1-2 (2004) 173-188
12. Karayiorgou M., and Gogos J.A. The molecular genetics of the 22q11-associated schizophrenia. Brain Res. Mol. Brain Res. 132 2 (2004) 95-104
13. Laeng P., Pitts R.L., Lemire A.L., Drabik C.E., Weiner A., Tang H., Thyagarajan R., Mallon B.S., and Altar C.A. The mood stabilizer valproic acid stimulates GABA neurogenesis from rat forebrain stem cells. J. Neurochem. 91 1 (2004) 238-251
14. Li T., Ma X., Sham P.C., Sun X., Hu X., Wang Q., Meng H., Deng W., Liu X., Murray R.M., and Collier D.A. Evidence for association between novel polymorphisms in the PRODH gene and schizophrenia in a Chinese population. Am. J. Med. Genet. B. Neuropsychiatr. Genet. 129 1 (2004) 13-15
15. Lindsay E.A. Chromosomal microdeletions: dissecting del22q11 syndrome. Nat. Rev., Genet. 2 11 (2001) 858-868
16. Lindsay E.A., Botta A., Jurecic V., Carattini-Rivera S., Cheah Y.C., Rosenblatt H.M., Bradley A., and Baldini A. Congenital heart disease in mice deficient for the DiGeorge syndrome region. Nature 401 6751 (1999) 379-383
17. Lindsay E.A., Vitelli F., Su H., Morishima M., Huynh T., Pramparo T., Jurecic V., Ogunrinu G., Sutherland H.F., Scambler P.J., Bradley A., and Baldini A. Tbx1 haploinsufficieny in the DiGeorge syndrome region causes aortic arch defects in mice. Nature 410 6824 (2001) 97-101
18. Liu H., Abecasis G.R., Heath S.C., Knowles A., Demars S., Chen Y.J., Roos J.L., Rapoport J.L., Gogos J.A., and Karayiorgou M. Genetic variation in the 22q11 locus and susceptibility to schizophrenia. Proc. Natl. Acad. Sci. U. S. A. 99 26 (2002) 16859-16864
19. Maynard T.M., Haskell G.T., Peters A.Z., Sikich L., Lieberman J.A., and LaMantia A.S. A comprehensive analysis of 22q11 gene expression in the developing and adult brain. Proc. Natl. Acad. Sci. U. S. A. 100 24 (2003) 14433-14438
20. Merscher S., Funke B., Epstein J.A., Heyer J., Puech A., Lu M.M., Xavier R.J., Demay M.B., Russell R.G., Factor S., Tokooya K., Jore B.S., Lopez M., Pandita R.K., Lia M., Carrion D., Xu H., Schorle H., Kobler J.B., Scambler P., Wynshaw-Boris A., Skoultchi A.I., Morrow B.E., and Kucherlapati R. TBX1 is responsible for cardiovascular defects in velo-cardio-facial/DiGeorge syndrome. Cell 104 4 (2001) 619-629
21. Middleton F.A., Mirnics K., Pierri J.N., Lewis D.A., and Levitt P. Gene expression profiling reveals alterations of specific metabolic pathways in schizophrenia. J. Neurosci. 22 7 (2002) 2718-2729
22. Mukai J., Liu H., Burt R.A., Swor D.E., Lai W.S., Karayiorgou M., and Gogos J.A. Evidence that the gene encoding ZDHHC8 contributes to the risk of schizophrenia. Nat. Genet. 36 7 (2004) 725-731
23. Murphy K.C., Jones L.A., and Owen M.J. High rates of schizophrenia in adults with velo-cardio-facial syndrome. Arch. Gen. Psychiatry 56 10 (1999) 940-945
24. Nalvarte I., Damdimopoulos A.E., and Spyrou G. Human mitochondrial thioredoxin reductase reduces cytochrome c and confers resistance to complex III inhibition. Free Radic. Biol. Med. 36 10 (2004) 1270-1278
25. Paylor R., and Lindsay E. Mouse models of 22q11 deletion syndrome. Biol. Psychiatry 59 12 (2006) 1172-1179
26. Paylor R., McIlwain K.L., McAninch R., Nellis A., Yuva-Paylor L.A., Baldini A., and Lindsay E.A. Mice deleted for the DiGeorge/velocardiofacial syndrome region show abnormal sensorimotor gating and learning and memory impairments. Hum. Mol. Genet. 10 23 (2001) 2645-2650
27. Prabakaran S., Swatton J.E., Ryan M.M., Huffaker S.J., Huang J.T., Griffin J.L., Wayland M., Freeman T., Dudbridge F., Lilley K.S., Karp N.A., Hester S., Tkachev D., Mimmack M.L., Yolken R.H., Webster M.J., Torrey E.F., and Bahn S. Mitochondrial dysfunction in schizophrenia: evidence for compromised brain metabolism and oxidative stress. Mol. Psychiatry 9 7 (2004) 684-697
28. Prescott K., Ivins S., Hubank M., Lindsay E., Baldini A., and Scambler P. Microarray analysis of the Df1 mouse model of the 22q11 deletion syndrome. Hum. Genet. 116 6 (2005) 486-496
29. Shifman S., Bronstein M., Sternfeld M., Pisante-Shalom A., Lev-Lehman E., Weizman A., Reznik I., Spivak B., Grisaru N., Karp L., Schiffer R., Kotler M., Strous R.D., Swartz-Vanetik M., Knobler H.Y., Shinar E., Beckmann J.S., Yakir B., Risch N., Zak N.B., and Darvasi A. A highly significant association between a COMT haplotype and schizophrenia. Am. J. Hum. Genet. 71 6 (2002) 1296-1302
30. Williams N.M., and Owen M.J. Genetic abnormalities of chromosome 22 and the development of psychosis. Curr. Psychiatry Rep. 6 3 (2004) 176-182
31. Yagi H., Furutani Y., Hamada H., Sasaki T., Asakawa S., Minoshima S., Ichida F., Joo K., Kimura M., Imamura S., Kamatani N., Momma K., Takao A., Nakazawa M., Shimizu N., and Matsuoka R. Role of TBX1 in human del22q11.2 syndrome. Lancet 362 9393 (2003) 1366-1373