Unexpected Insights into Pelvic Function Following Phosphodiesterase Manipulation-What's Next for Urology?

European Urology

Volumn 50, Issue 6, 2006, Pages 1153-1156

  McVary, Kevin T ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; CYCLIC GMP; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PAPAVERINE; PHOSPHODIESTERASE; PHOSPHODIESTERASE V; PHOSPHODIESTERASE V INHIBITOR; SILDENAFIL; STEROID 5ALPHA REDUCTASE INHIBITOR; TADALAFIL;

AUTONOMIC NERVOUS SYSTEM; CLINICAL TRIAL; DRUG EFFECT; EDITORIAL; ERECTILE DYSFUNCTION; HUMAN; ISCHEMIA; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROSTATE HYPERTROPHY; QUESTIONNAIRE; RISK FACTOR; SELF ESTEEM; SEXUAL DYSFUNCTION; SMOOTH MUSCLE RELAXATION; TREATMENT RESPONSE; URINARY TRACT DISEASE; WELLBEING;

3',5'-CYCLIC-GMP PHOSPHODIESTERASE; AGED; AGED, 80 AND OVER; HUMANS; IMPOTENCE; MALE; MIDDLE AGED; PELVIS; PHOSPHODIESTERASE INHIBITORS; PROSTATIC HYPERPLASIA; URINARY BLADDER DISEASES;

EID: 33750630434     PISSN: 03022838     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.eururo.2006.09.014     Document Type: Editorial

References (10)

1. Ückert S., Hedlund P., Andersson K.E., Truss M.C., Jonas U., and Stief C.G. Update on phosphodiesterase (PDE) isoenzymes as pharmacologic targets in urology: present and future. Eur Urol 50 (2006) 1194-1207
2. McVary KT, Monnig W, Camps JL, Young JM, Tseng LJ, van den Ende G. Sildenafil citrate improves erectile function and urinary symptoms in men with erectile dysfunction and lower urinary tract symptoms associated with benign prostatic hyperplasia: a randomized double-blind trial. J Urol. In press.
3. McVary K., Roehrborn C., Kaminetsky J., et al. The efficacy and safety of tadalafil administered once a day for lower urinary tract symptoms (LUTS) in men with benign prostatic hyperplasia (BPH). Eur Urol Suppl 5 (2006) 196 (abstract 696)
4. Macfarlane G.J., Botto H., Sagnier P.P., Teillac P., Richard F., and Boyle P. The relationship between sexual life and urinary condition in the French community. J Clin Epidemiol 49 (1996) 1171
5. Bloch W., Klotz T., Loch C., Schmidt G., Engelmann U., and Addicks K. Distribution of NOS implies a regulation of circulation, SM tone, and secretory function in the human prostate by NO. Prostate 33 (1997) 1-8
6. McVary K.T., Razzaq A., Lee C., et al. Growth of the rat prostate gland is facilitated by the autonomic nervous system. Biol Reprod 51 (1994) 99-107
7. Golomb E., Rosenzweig N., Ellam R., et al. Spontaneous hyperplasia of the ventral lobe of the prostate in aging genetically hypertensive rats. J Androl 21 (2000) 58-64
8. Glynn R.J., Campion E.W., Bouchard G.R., et al. The development of benign prostatic hyperplasia among volunteers in the Normative Aging Study. Am J Epidemiol 121 (1985) 78-90
9. McVary K.T., Rademaker A., Lloyd G.L., and Gann P. Autonomic nervous system overactivity in men with lower urinary tract symptoms secondary to benign prostatic hyperplasia. J Urol 174 (2005) 1327-1433
10. Tarcan T., Azadzoi K.M., Siroky M.B., Goldstein I., and Krane R.J. Age related erectile and voiding dysfunction: the role of arterial insufficiency. Br J Urol 82 suppl 1 (1998) 26-33 (This report is a nice summary of the link of pelvic ischemia and/or lipid disorders and bladder, prostate and penile dysfunction.)