A prospective cohort study on the absolute incidence of venous thromboembolism and arterial cardiovascular disease in asymptomatic carriers of the prothrombin 20210A mutation

Blood

Volumn 108, Issue 8, 2006, Pages 2604-2607

  Coppens, Michiel ^a   Van De Poel, Marlene H ^b   Bank, Ivan ^b   Hamulyak, Karly ^b   Van Der Meer, Jan ^b   Veeger, Nic J ^b   Prins, Martin H ^b   Buller, Harry R ^b   Middeldorp, Saskia ^b  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

PROTHROMBIN;

ADULT; AGED; ARTERY DISEASE; ARTICLE; ATHEROSCLEROSIS; CARDIOVASCULAR DISEASE; CONTROLLED STUDY; DNA DETERMINATION; FEMALE; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; MALE; MUTATION; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; RISK ASSESSMENT; VENOUS THROMBOEMBOLISM; ADOLESCENT; COHORT ANALYSIS; CORONARY ARTERY ATHEROSCLEROSIS; GENETICS; HETEROZYGOTE; MIDDLE AGED; NETHERLANDS; POINT MUTATION; PROSPECTIVE STUDY; RISK FACTOR; THROMBOEMBOLISM; VEIN THROMBOSIS;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; COHORT STUDIES; CORONARY ARTERIOSCLEROSIS; FEMALE; HETEROZYGOTE; HUMANS; MALE; MIDDLE AGED; NETHERLANDS; POINT MUTATION; PROSPECTIVE STUDIES; PROTHROMBIN; RISK FACTORS; THROMBOEMBOLISM; VENOUS THROMBOSIS;

EID: 33750626078     PISSN: 00064971     EISSN: 00064971     Source Type: Journal    
DOI: 10.1182/blood-2006-04-016527     Document Type: Article

References (17)

1. Poort SR, Rosendaal FR, Reitsma PH, Bertina RM. A common genetic variation in the 3′-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood. 1996;88:3698-3703.
2. Hillarp A, Zoller B, Svensson PJ, Dahlback B. The 20210 A allele of the prothrombin gene is a common risk factor among Swedish outpatients with verified deep venous thrombosis. Thromb Haemost. 1997;78:990-992.
3. Leroyer C, Mercier B, Oger E, et al. Prevalence of 20210 A allele of the prothrombin gene in venous thromboembolism patients. Thromb Haemost. 1998;80:49-51.
4. Margaglione M, Brancaccio V, Giuliani N, et al. Increased risk for venous thrombosis in carriers of the prothrombin G→A20210 gene variant. Ann Intern Med. 1998;129:89-93.
5. Souto JC, Coll I, Llobet D, et al. The prothrombin 20210A allele is the most prevalent genetic risk factor for venous thromboembolism in the Spanish population. Thromb Haemost. 1998;80:366-369.
6. Boekholdt SM, Bijsterveld NR, Moons AH, et al. Genetic variation in coagulation and fibrinolytic proteins and their relation with acute myocardial infarction: a systematic review. Circulation. 2001;104:3063-3068.
7. Kim RJ, Becker RC. Association between factor V Leiden, prothrombin G20210A, and methylenetetrahydrofolate reductase C677T mutations and events of the arterial circulatory system: a meta-analysis of published studies. Am Heart J. 2003;146:948-957.
8. Burzotta F, Paciaroni K, De Stefano V, et al. G20210A prothrombin gene polymorphism and coronary ischaemic syndromes: a phenotype-specific meta-analysis of 12 034 subjects. Heart. 2004;90:82-86.
9. Bank I, Libourel EJ, Middeldorp S, et al. Prothrombin 20210A mutation: a mild risk factor for venous thromboembolism but not for arterial thrombotic disease and pregnancy-related complications in a family study. Arch Intern Med. 2004;164:1932-1937.
10. Pabinger I, Kyrle PA, Heistinger M, et al. The risk of thromboembolism in asymptomatic patients with protein C and protein S deficiency: a prospective cohort study. Thromb Haemost. 1994;71:441-445.
11. Simioni P, Prandoni P, Girolami A. Low rate of venous thromboembolism in asymptomatic relatives of probands with factor V Leiden mutation [letter]. Ann Intern Med. 1999;130:538.
12. Sanson BJ, Simioni P, Tormene D, et al. The incidence of venous thromboembolism in asymptomatic carriers of a deficiency of antithrombin, protein C, or protein S: a prospective cohort study. Blood. 1999;94:3702-3706.
13. Middeldorp S, Meinardi JR, Koopman MM, et al. A prospective study of asymptomatic carriers of the factor V Leiden mutation to determine the incidence of venous thromboembolism. Ann Intern Med. 2001;135:322-327.
14. Vossen CY, Conard J, Fontcuberta J, et al. Risk of a first venous thrombotic event in carriers of a familial thrombophilic defect: The European Prospective Cohort on Thrombophilia (EPCOT). J Thromb Haemost. 2005;3:459-464.
15. Bank I, Coppens M, Van de Poel MH, et al. A prospective cohort study of asymptomatic individuals with elevated factor VIII:c to determine the absolute incidence of venous and arterial thromboembolism. J Thromb Haemost. 2005;3:(suppl 1):P1056.
16. Tormene D, Simioni P, Pagnan A, Prandoni P. The G20210A prothrombin gene mutation: is there room for screening families? J Thromb Haemost. 2004;2:1487-1488.
17. Nordstrom M, Lindblad B, Bergqvist D, Kjellstrom T. A prospective study of the incidence of deep-vein thrombosis within a defined urban population. J Intern Med. 1992;232:155-160.