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84985570392
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For reviews of the Stille reaction see:. Stille J.K. Angew. Chem., Int. Ed. Engl. 25 (1986) 508-524
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Farina, V.1
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13
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33750630394
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Astles, P. C.; Baker, S. R.; Keenan, M.; Vernier, J. M.; Sanderson, A. J.; Cube, R. V.; Martinez-Perez, J. A.; Maeto Herranz, A. I.; Dell, C. P.; Gutierrez, S.; Prietro, L.; Smith, C. W. WO 2003062235, Modulators of Acetylcholine Receptors; Chem. Abstr. 2003, 139, 149805. This work has been in part presented at YCI XIII, London, UK and at ASCMC Moscow 04.
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4143081487
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Solodenka W., Schön U., Messinger J., Glinschert A., and Kirschning A. Synlett 10 (2004) 1699-1702
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Solodenka, W.1
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21
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0033598384
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Alterman M., Andersson H.O., Garg N., Ahlsén G., Lövgren S., Classon B., Danielson U.H., Kvarnström I., Vrang L., Unge T., Samuelsson B., and Hallberg A. J. Med. Chem. 42 (1999) 3835-3844
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22
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0033546263
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Olofsson K., Kim S.-Y., Larhed M., Curran D.P., and Hallberg A. J. Org. Chem. 64 (1999) 4539-4541
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23
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0034699220
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Cockerill G.S., Easterfield H.J., Percy J.M., and Pintat S. J. Chem. Soc., Perkin Trans. 1 16 (2000) 2591-2599
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Cockerill, G.S.1
Easterfield, H.J.2
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Pintat, S.4
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25
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33750612519
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note
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CEM Discovery. Multimode cavity system which continuously adjusts the applied wattage to maintain the desired temperature.
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26
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33750628413
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note
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3) yielding 2 as a light brown solid (587 mg, 79% yield).
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27
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33750622456
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note
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4 in toluene.
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28
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33750628729
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note
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17 under nitrogen. The tube was closed, positioned in the microwave cavity and irradiated at 200 W for the given times. After allowing the tube to cool to room temperature within the microwave cavity for a couple of minutes, the crude mixture was concentrated and purified by flash column chromatography.
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29
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33750627289
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note
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The reactions were performed in a heavy-walled Pyrex tube equipped with a sealable metal cap and silicon septum. The reaction volume filled no more than two thirds of the total volume, thereby allowing space for pressure build-up during the microwave treatment.
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31
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33750634115
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note
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Under the conditions described, LCMS showed no sign of 10 after 2 h of conventional reflux; an aliquot was then heated in the microwave (110 °C/200 W, 5 min) after which LCMS showed full consumption of 4 and formation of 10.
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Appukkuttan P., Husain M., Gupta R.K., Parmar V.S., and Van der Eycken E. Synlett (2006) 1491-1496
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(2006)
Synlett
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Appukkuttan, P.1
Husain, M.2
Gupta, R.K.3
Parmar, V.S.4
Van der Eycken, E.5
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