Association analysis of the LAG3 and CD4 genes in multiple sclerosis in two independent populations

Journal of Neuroimmunology

Volumn 180, Issue 1-2, 2006, Pages 193-198

  Lundmark, Frida ^a   Harbo, Hanne F ^b,c   Celius, Elisabeth G ^c   Saarela, Janna ^d   Datta, Pameli ^e   Oturai, Annette ^e   Lindgren, Cecilia M ^a   Masterman, Thomas ^a   Salter, Hugh ^f   Hillert, Jan ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF OSLO   (Norway)

^c ULLEVÅL UNIVERSITY HOSPITAL   (Norway)

^d NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^e Rigshospitalet   (Denmark)

^f ASTRAZENECA R AND D   (Sweden)

Author keywords

Association; CD4; LAG3; Multiple sclerosis

Indexed keywords

CD4 ANTIGEN;

ARTICLE; DISEASE ASSOCIATION; GENE; GENETIC PREDISPOSITION; GENOTYPE; HUMAN; LAG3 GENE; MULTIPLE SCLEROSIS; PATHOGENESIS; POPULATION GENETICS; PRIORITY JOURNAL;

EID: 33750621302     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2006.08.009     Document Type: Article

References (34)

1. Akesson E., Oturai A., Berg J., Fredrikson S., Andersen O., Harbo H.F., Laaksonen M., Myhr K.M., Nyland H.I., Ryder L.P., Sandberg-Wollheim M., Sorensen P.S., Spurkland A., Svejgaard A., Holmans P., Compston A., Hillert J., and Sawcer S. A genome-wide screen for linkage in Nordic sib-pairs with multiple sclerosis. Genes Immun. 3 (2002) 279-285
2. Andreae S., Piras F., Burdin N., and Triebel F. Maturation and activation of dendritic cells induced by lymphocyte activation gene-3 (CD223). J. Immunol. 168 (2002) 3874-3880
3. Avice M.N., Sarfati M., Triebel F., Delespesse G., and Demeure C.E. Lymphocyte activation gene-3, a MHC class II ligand expressed on activated T cells, stimulates TNF-alpha and IL-12 production by monocytes and dendritic cells. J. Immunol. 162 (1999) 2748-2753
4. Baixeras E., Huard B., Miossec C., Jitsukawa S., Martin M., Hercend T., Auffray C., Triebel F., and Piatier-Tonneau D. Characterization of the lymphocyte activation gene 3-encoded protein. A new ligand for human leukocyte antigen class II antigens. J. Exp. Med. 176 (1992) 327-337
5. Barrett J.C., Fry B., Maller J., and Daly M.J. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 15 (2005) 263-265
6. Broadley S., Sawcer S., D'Alfonso S., Hensiek A., Coraddu F., Gray J., Roxburgh R., Clayton D., Buttinelli C., Quattrone A., Trojano M., Massacesi L., and Compston A. A genome screen for multiple sclerosis in Italian families. Genes Immun. 2 (2001) 205-210
7. Bruniquel D., Borie N., Hannier S., and Triebel F. Regulation of expression of the human lymphocyte activation gene-3 (LAG-3) molecule, a ligand for MHC class II. Immunogenetics 48 (1998) 116-124
8. Colhoun H.M., McKeigue P.M., and Davey Smith G. Problems of reporting genetic associations with complex outcomes. Lancet 361 (2003) 865-872
9. Coraddu F., Sawcer S., D'Alfonso S., Lai M., Hensiek A., Solla E., Broadley S., Mancosu C., Pugliatti M., Marrosu M.G., and Compston A. A genome screen for multiple sclerosis in Sardinian multiplex families. Eur. J. Hum. Genet. 9 (2001) 621-626
10. Dyment D.A., Ebers G.C., and Sadovnick A.D. Genetics of multiple sclerosis. Lancet Neurol. 3 (2004) 104-110
11. Ebers G.C., and Sadovnick A.D. The role of genetic factors in multiple sclerosis susceptibility. J. Neuroimmunol. 54 (1994) 1-17
12. Ebers G.C., Kukay K., Bulman D.E., Sadovnick A.D., Rice G., Anderson C., Armstrong H., Cousin K., Bell R.B., Hader W., Paty D.W., Hashimoto S., Oger J., Duquette P., Warren S., Gray T., O'Connor P., Nath A., Auty A., Metz L., Francis G., Paulseth J.E., Murray T.J., Pryse-Phillips W., Nelson R., Freedman M., Brunet D., Bouchard J.P., Hinds D., and Risch N. A full genome search in multiple sclerosis. Nat. Genet. 13 (1996) 472-476
13. Eraksoy M., Kurtuncu M., Akman-Demir G., Kilinc M., Gedizlioglu M., Mirza M., Anlar O., Kutlu C., Demirkiran M., Idrisoglu H.A., Compston A., Sawcer S., and Turkish Multiple Sclerosis Genetics Study Group. A whole genome screen for linkage in Turkish multiple sclerosis. J. Immunol. 143 (2003) 17-24
14. Feito M.J., Ballester S., Diez-Orejas R., Ojeda G., Criado G., Portoles P., and Rojo J.M. CD4 dependence of activation threshold and TCR signalling in mouse T lymphocytes. Scand. J. Immunol. 45 (1997) 166-174
15. Haines J.L., Ter-Minassian M., Bazyk A., Gusella J.F., Kim D.J., Terwedow H., Pericak-Vance M.A., Rimmler J.B., Haynes C.S., Roses A.D., Lee A., Shaner B., Menold M., Seboun E., Fitoussi R.P., Gartioux C., Reyes C., Ribierre F., Gyapay G., Weissenbach J., Hauser S.L., Goodkin D.E., Lincoln R., Usuku K., and Oksenberg J.R. A complete genomic screen for multiple sclerosis underscores a role for the major histocompatibility complex. The Multiple Sclerosis genetics group. Nat. Genet. 13 (1996) 469-471
16. Hensiek A.E., Roxburgh R., Smilie B., Coraddu F., Akesson E., Holmans P., Sawcer S.J., and Compston D.A. Updated results of the United Kingdom linkage-based genome screen in multiple sclerosis. J. Immunol. 143 (2003) 25-30
17. Huard B., Prigent P., Pages F., Bruniquel D., and Triebel F. T cell major complex class II molecules down-regulate CD4+ T cell clone responses following LAG-3 binding. Eur. J. Immunol. 26 (1996) 1180-1186
18. Kenealy S.J., Pericak-Vance M.A., and Haines J.L. The genetic epidemiology of multiple sclerosis. J. Neuroimmunol. 143 (2003) 7-12
19. Kenealy S.J., Babron M.C., Bradford Y., Schnetz-Boutaud N., Haines J.L., Rimmler J.B., Schmidt S., Pericak-Vance M.A., Barcellos L.F., Lincoln R.R., Oksenberg J.R., Hauser S.L., Clanet M., Brassat D., Edan G., Yaouanq J., Semana G., Cournu-Rebeix I., Lyon-Caen O., and Fontaine B. American-French Multiple Sclerosis Genetics Group. A second-generation genomic screen for multiple sclerosis. Am. J. Hum. Genet. 75 (2004) 1070-1080
20. Krummel M.F., and Davis M.M. Dynamics of the immunological synapse: finding, establishing and solidifying a connection. Curr. Opin. Immunol. 14 (2002) 66-67
21. Kuokkanen S., Gschwend M., Rioux J.D., Daly M.J., Terwilliger J.D., Tienari P.J., Wikstrom J., Palo J., Stein L.D., Hudson T.J., Lander E.S., and Peltonen L. Genomewide scan for multiple sclerosis in Finnish multiplex families. Am. J. Hum. Genet. 61 (1997) 1379-1387
22. Kurtzke J.F. Epidemiologic evidence for multiple sclerosis as an infection. Clin. Microbiol. Rev. 6 (1993) 382-427
23. Lassmann H. Neuropathology in multiple sclerosis: new concepts. Mult. Scler. 4 (1998) 93-98
24. McDonald W.I., Compston A., Edan G., Goodkin D., Hartung H.P., Lublin F.D., McFarland H.F., Paty D.W., Polman C.H., Reingold S.C., Sandberg-Wollheim M., Sibley W., Thompson A., van den Noort S., Weinshenker B.Y., and Wolinsky J.S. Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis. Ann. Neurol. 50 (2001) 121-127
25. O'Connor P., and on behalf of the Canadian Multiple Sclerosis Working Group. Key issues in the diagnosis and treatment of multiple sclerosis. Neurology 59 (2002) S1-S33
26. Pettinelli C.B., and McFarlin D.E. Adoptive transfer of experimental allergic encephalomyelitis in SJL/J mice after in vitro activation in lymph node cells by myelin basic protein: requirement for Lyt 1 + 2-T lymphocytes. J. Immunol. 127 (1981) 1420-1430
27. Poser C.M., Paty D.W., Scheinberg L., McDonald W.I., Davis F.A., Ebers G.C., Johnson K.P., Sibley W.A., Silberberg D.H., and Tourtellotte W.W. New diagnostic criteria multiple sclerosis: guidelines for research protocols. Ann. Neurol. 13 (1983) 227-231
28. IMSGC, Sawcer S., Ban M., Maranian M., Yeo T.W., Compston A., Kirby A., Daly M.J., De Jager P.L., Walsh E., Lander E.S., Rioux J.D., Hafler D.A., Ivinson A., Rimmler J., Gregory S.G., Schmidt S., Pericak-Vance M.A., Akesson E., Hillert J., Datta P., Oturai A., Ryder L.P., Harbo H.F., Spurkland A., Myhr K.M., Laaksonen M., Booth D., Heard R., Stewart G., Lincoln R., Barcellos L.F., Hauser S.L., Oksenberg J.R., Kenealy S.J., Haines J.L., and International Multiple Sclerosis Genetics Consortium. A High-Density Screen for Linkage in Multiple Sclerosis. Am. J. Hum. Genet. 77 (2005) 454-467
29. Sawcer S., Jones H.B., Feakes R., Gray J., Smaldon N., Chataway J., Robertson N., Clayton D., Goodfellow P.N., and Compston A. A genome screen in multiple sclerosis reveals susceptibility loci on chromosome 6p21 and 17q22. Nat. Genet. 13 (1996) 464-468
30. Swanberg M., Lidman O., Padyukov L., Eriksson P., Akesson E., Jagodic M., Lobell A., Khademi M., Borjesson O., Lindgren C.M., Lundman P., Brookes A.J., Kere J., Luthman H., Alfredsson L., Hillert J., Klareskog L., Hamsten A., Piehl F., and Olsson T. MHC2TA is associated with differential MHC molecule expression and susceptibility to rheumatoid arthritis, multiple sclerosis and myocardial infarction. Nat. Genet. 37 (2005) 486-494
31. Triebel F., Jitsukawa S., Baixeras E., Roman-Roman S., Genevee C., Viegas-Pequignot E., and Hercend T. LAG-3, a novel lymphocyte activation gene closely related to CD4. J. Exp. Med. 171 (1990) 1393-1405
32. Wang J.H., Meijers R., Xiong Y., Liu J.H., Sakihama T., Zhang R., Joachimiak A., and Reinherz E.L. Crystal structure of the human CD4 N-terminal two-domain fragment complexed to a class II MHC molecule. Proc. Natl. Acad. Sci. 98 (2001) 10799-10804
33. Xu C., Dai Y., Lorentzen J.C., Dahlman I., Olsson T., and Hillert J. Linkage analysis in multiple sclerosis of chromosomal regions syntenic to experimental autoimmune disease loci. Eur. J. Hum. Genet. 9 (2001) 458-463
34. Zhang Z., Duvefelt K., Svensson F., Masterman T., Jonasdottir G., Salter H., Emahazion T., Hellgren D., Falk G., Olsson T., Hillert J., and Anvret M. Two genes encoding immune-regulatory molecules (LAG3 and IL7R) confer susceptibility to multiple sclerosis. Genes Immun. 6 (2005) 145-152