Assessing adrenal function in primary care settings with a single sample subcutaneous glucagon test

Journal of Pediatrics

Volumn 149, Issue 5, 2006, Pages 682-686

  Kappy, Michael S ^a   Drake, Amanda ^a   Gao, Dexiang ^a   Ratliff, Rebecca ^a  

^a CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOTROPIN; GLUCAGON;

ADOLESCENT; ADRENAL FUNCTION; ARTICLE; BLOOD SAMPLING; CHILD; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; FEMALE; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYPOGLYCEMIA; HYPOPHYSIS ADRENAL SYSTEM; MAJOR CLINICAL STUDY; MALE; NAUSEA; PRIMARY MEDICAL CARE; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; VOMITING;

ADOLESCENT; ADRENAL GLAND DISEASES; ADRENAL GLANDS; ADRENOCORTICOTROPIC HORMONE; BLOOD GLUCOSE; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; DOSE-RESPONSE RELATIONSHIP, DRUG; DWARFISM; FASTING; FEMALE; GLUCAGON; GROWTH DISORDERS; HEXOKINASE; HORMONES; HUMANS; HYDROCORTISONE; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; IMMUNOENZYME TECHNIQUES; INFANT; INFANT, NEWBORN; MALE; PITUITARY DISEASES; PITUITARY-ADRENAL SYSTEM; PRIMARY HEALTH CARE; RADIOIMMUNOASSAY; SENSITIVITY AND SPECIFICITY; TIME FACTORS;

EID: 33750615213     PISSN: 00223476     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpeds.2006.07.033     Document Type: Article

References (20)

1. Sizonenko P.L. Effects of inhaled or nasal glucocorticoids on adrenal function and growth. J Pediatr Endocrinol Metab 15 (2002) 5-26
2. Chang C.C.C., and Tam A.Y.C. Suppression of adrenal function in children on inhaled steroids. J Paediatr Child Health 27 (1991) 232-234
3. Kannisto S., Korppi M., Remes K., and Voutilainen R. Adrenal suppression evaluated by a low-dose adrenocorticotropin test, and growth in asthmatic children treated with inhaled steroids. J Clin Endocrinol Metab 85 (2000) 652-657
4. Broidie J., Soferman R., Kivity S., Galander A., Dickstein G., Spirer Z., et al. Low-dose adrenocorticotropin test reveals impaired adrenal function in patients taking inhaled steroids. J Clin Endocrinol Metab 80 (1995) 1243-1246
5. Allen D.B. Effects of inhaled steroids on growth, bone metabolism, and adrenal function. Adv Pediatr 53 (2006) (in press)
6. Wood J.B., James V.H.T., Frankland A.W., and Landon J. A rapid test of adrenocortical function. Lancet i (1965) 243-245
7. Dickstein G., Shechner C., Nicholson W.E., Rosner I., Shen-Orr Z., Adani F., et al. Adrenocorticotropin stimulation test: effects of basal cortisol level, time of day, and suggested new sensitive low dose test. J Clin Endocrinol Metab 72 (1991) 773-778
8. Beishuizen A., van Lijf J.H., Lekkerkerker J.F.F., and Vermes I. The low-dose (1 μg) ACTH stimulation test for assessment of the HPA axis. Netherl J Med 56 (2000) 91-99
9. Cohen O., Sidi Y., Barazin M., and Karasik A. Low-dose ACTH test: a word of caution. J Clin Endocrinol Metab 81 (1996) 3129
10. Murphy H., Livesey J., Espiner E.A., and Donald R.A. The low-dose ACTH test: a further word of caution. J Clin Endocrinol Metab 83 (1998) 712-713
11. Annane D. Low-dose adrenocorticotropic hormone test is not ready for routine adrenal function testing in the intensive care unit. Crit Care Med 33 (2005) 2688-2689
12. Drash A., Field J.B., Garces L.Y., Kenny F.M., Mintz D., and Vasquez A.M. Endogenous insulin and growth hormone response in children with newly diagnosed diabetes mellitus. Pediat Res 2 (1968) 94-102
13. Vanderschueren-Lodeweyckx M., Wolter R., Malveaux P., Eggermont E., and Eeckels R. The glucagon stimulation test: Effect on plasma growth hormone and on immunoreactive insulin, cortisol, and glucose in children. J Pediatr 85 (1974) 182-187
14. Spathis G.S., Bloom S.R., Jeffcoate W.J., Millar J.G.B., Kurtz A., Pyasena M.R.D., et al. Subcutaneous glucagon as a test of the ability of the pituitary to secrete GH and ACTH. Clin Endocrinol 3 (1974) 175-186
15. Rao R.H., and Spathis G.S. Intramuscular glucagon as a provocative stimulus for the assessment of pituitary function: Growth hormone and cortisol responses. Metabolism 36 (1987) 658-663
16. Leong K.S., Walker A.B., Martin I., Wile D., Wilding J., and MacFarlane I.A. An audit of 500 subcutaneous glucagon stimulation tests to assess growth hormone and ACTH secretion in patients with hypothalamic-pituitary disease. Clin Endocrinol 54 (2001) 463-468
17. Arvat E., Maccagno B., Ramunni J., Maccario M., Giordano R., Broglio F., et al. Interaction between glucagon and human corticotrophin-releasing hormone or vasopressin on ACTH and cortisol secretion in humans. Eur J Endocrinol 143 (2000) 99-104
18. Johnstone H.C., and Cheetham T.D. GH and cortisol response to glucagon administration in short children. Horm Res 62 (2004) 27-32
19. Chanoine J.-P., Rebuffat E., Kahn A., Bergmann P., and Van Vliet G. Glucose, growth hormone, cortisol, and insulin responses to glucagon injection in normal infants, aged 0.5-12 months. J Clin Endocrinol Metab 80 (1995) 3032-3035
20. Bottner A., Kratzsch J., Liebermann S., Keller A., Pfaffle R.W., Kiess W., et al. Comparison of adrenal function tests in children: the glucagon stimulation test allows the simultaneous assessment of adrenal function and growth hormone response in children. J Pediatr Endocrinol Metab 18 (2005) 433-442