Candida albicans: to be or not to be recognized by TLR4? Response to "Both TLR2 and TLR4 are involved in the recognition of Candida albicans" by M.G. Netea et al.,Microbes and Infection 8 (2006) 2821-2822

Microbes and Infection

Volumn 8, Issue 12-13, 2006, Pages 2823-2824

  Gil, M Luisa ^a   Gozalbo, Daniel ^a  

^a UNIVERSITY OF VALENCIA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4;

ANTIGEN RECOGNITION; CANDIDA ALBICANS; CANDIDIASIS; CYTOKINE PRODUCTION; DNA POLYMORPHISM; HUMAN; IMMUNE RESPONSE; LETTER; MACROPHAGE; NONHUMAN; PRIORITY JOURNAL;

CANDIDA ALBICANS;

EID: 33750611326     PISSN: 12864579     EISSN: 1769714X     Source Type: Journal    
DOI: 10.1016/j.micinf.2006.07.022     Document Type: Letter

References (13)

1. M.L. Gil, D. Gozalbo, TLR2, but not TLR4, triggers cytokine production by murine cells in response to Candida albicans yeasts and hyphae, Microb. Infect., in press. doi:10.1016/j.micinf.2006.03.014
2. M.G. Netea, J.W.M. Van der Meer, B.J. Kullberg, Both TLR2 and TLR4 are involved in the recognition of Candida albicans, Microb. Infect., in press. doi:10.1016/j.micinf.2006.07.021
3. Gil M.L., Fradelizi D., and Gozalbo D. TLR2: for or against Candida albicans. Trends Microbiol. 13 (2005) 298-299
4. Netea M.G., Van der Graaf C.A.A., Vonk A.G., Verschueren I., Van der Meer J.W.M., and Kullberg B.J. The role of Toll-like receptor (TLR) 2 and TLR4 in the host defense against disseminated candidiasis. J. Infect. Dis. 185 (2002) 1483-1489
5. Bellocchio S., Montagnoli C., Bozza S., Gaziano R., Rossi G., Mambula S.S., Vecchi A., Mantovani A., Levitz S.M., and Romani L. The contribution of the Toll-Like/IL-1 receptor superfamily to innate and adaptive immunity to fungal pathogens in vivo. J. Immunol. 172 (2004) 3059-3069
6. Netea M.G., Sutmuller R., Hermann C., Van der Graaf C.A.A., Van der Meer J.W.M., Van Krieken J.H., Hartung T., Adema G., and Kullberg B.J. Toll-like receptor 2 suppresses immunity against Candida albicans through induction of IL-10 and regulatory T cells. J. Immunol. 172 (2004) 3712-3718
7. Van der Graaf C.A.A., Netea M.G., Verschueren I., van der Meer J.W.M., and Kullberg B.J. Differential cytokine production and Toll-like receptor signaling pathways by Candida albicans blastoconidia and hyphae. Infect. Immun. 73 (2005) 7458-7464
8. Netea M.G., Gow N.A.R., Munro C.A., Bates S., Collins C., Ferwerda G., et al. Immune sensing of Candida albicans requires cooperative recognition of mannans and glucans by lectin and Toll-like receptors. J. Clin. Invest. 116 (2006) 1642-1650
9. Jouault T., Ibata-Ombetta S., Takeuchi O., Trinel P.A., Sacchetti P., Lefebvre P., Akira S., and Poulain D. Candida albicans phospholipomannan is sensed through Toll-like receptors. J. Infect. Dis. 188 (2003) 165-172
10. Blasi E., Mucci A., Neglia R., Pezzini F., Colombari B., Radzioch D., et al. Biological importance of the two Toll-like receptors, TLR2 and TLR4, in macrophage response to infection with Candida albicans. FEMS Immunol. Med. Microbiol. 44 (2005) 69-79
11. Gil M.L., and Gozalbo D. About the role of TLR2 and TLR4 in cytokine secretion by murine macrophages in response to Candida albicans. FEMS Immunol. Med. Microbiol. 46 (2006) 1-2
12. Van der Graaf C.A.A., Netea M.G., Morré S.A., Den Heijer M., Verweij P.E., van der Meer J.W.M., and Kullberg B.J. Toll-like receptor 4 Asp299Gly/Thr399Ile polymorphisms are a risk factor for Candida bloodstream infection. Eur. Cytokine Netw. 17 (2006) 29-34
13. Wheeler R.T., and Fink G.R. A drug-sensitive genetic network masks fungi from the immune system. PLoS Pathog. 2 (2006) e35 10.1371/journal.ppat.0020035