A randomized factorial study of the effects of long-term garlic and micronutrient supplementation and of 2-wk antibiotic treatment for Helicobacter pylori infection on serum cholesterol and lipoproteins

American Journal of Clinical Nutrition

Volumn 84, Issue 4, 2006, Pages 912-919

  Zhang, Lian ^a   Gail, Mitchell H ^b   Wang, Yu Que ^a   Brown, Linda Morris ^b   Pan, Kai Feng ^a   Ma, Jun Ling ^a   Amagase, Harunobu ^c   You, Wei Cheng ^a   Moslehi, Roxana ^b  

^a PEKING UNIVERSITY CANCER HOSPITAL AND INSTITUTE   (China)

^b NATIONAL CANCER INSTITUTE   (United States)

^c Wakunaga of America Co Ltd   (United States)

Author keywords

Blood lipids; Cardiovascular disease; China; Cholesterol; Garlic supplementation; Helicobacter pylori antibiotic therapy; Vitamin supplementation

Indexed keywords

ALPHA TOCOPHEROL; AMOXICILLIN; ANTIBIOTIC AGENT; ASCORBIC ACID; CHOLESTEROL; GARLIC EXTRACT; HIGH DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; OMEPRAZOLE; SELENIUM; TRACE ELEMENT; ANTIINFECTIVE AGENT; ANTIULCER AGENT; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPOPROTEIN;

ADULT; ARTICLE; BACTERIAL INFECTION; CHINA; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; GARLIC; HELICOBACTER PYLORI; HUMAN; LIPOPROTEIN BLOOD LEVEL; LONG TERM CARE; RANDOMIZED CONTROLLED TRIAL; STOMACH LESION; BLOOD; DRUG ADMINISTRATION; DRUG EFFECT; FACTORIAL ANALYSIS; FEMALE; HELICOBACTER INFECTION; MALE; MIDDLE AGED; RURAL POPULATION;

ALLIUM SATIVUM; HELICOBACTER PYLORI;

AMOXICILLIN; ANTI-BACTERIAL AGENTS; ANTI-ULCER AGENTS; CHINA; CHOLESTEROL; CHOLESTEROL, HDL; CHOLESTEROL, LDL; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; FACTOR ANALYSIS, STATISTICAL; FEMALE; GARLIC; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; LIPOPROTEINS; MALE; MICRONUTRIENTS; MIDDLE AGED; OMEPRAZOLE; RURAL POPULATION;

EID: 33750610655     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/84.4.912     Document Type: Article

References (27)

1. National Heart, Lung, and Blood Institute. Facts about blood cholesterol. Bethesda, MD: National Institutes of Health, 1994.
2. Banerjee S, Maulik S. Effect of garlic on cardiovascular disorders; a review. Nutr J 2002;1:1-14.
3. Alder R, Lookinland S, Berry JA, et al. A systematic review of the effectiveness of garlic as an anti-hyperlipidemic agent. J Am Acad Nurse Pract 2003;15:120 -9.
4. Stevinson C, Pittler M, Ernst E, et al. Garlic for treating hypercholesterolemia. Ann Intern Med 2000;133:420 -9.
5. Turner B, MØlgaard C, Marckmann P. Effect of garlic (Allium sativum) powder tablets on serum lipids, blood pressure and arterial stiffness in normo-lipidaemic volunteers: a randomized, double-blind, placebo-controlled trial. Br J Nutr 2004;92:701-6.
6. Gail M, You WC, Chang YS, et al. Factorial trial of three interventions to reduce the progression of precancerous gastric lesions in Shandong China: design issues and initial data. Control Clin Trials 1998;19:352-69.
7. Blot WJ, Li JY, Taylor PR, et al. Nutrition intervention trials in Linxian, China: supplementation with specific vitamin/mineral combinations, cancer incidence, and disease-specific mortality in the general population. J Natl Cancer Inst 1993;85:1483-92.
8. You WC, Chang YS, Heinrich J, et al. An intervention trial to inhibit the progression of precancerous gastric lesions: compliance, serum micronutrients and S-allyl cysteine levels and toxicity. Eur J Cancer Prev 2001;10:257-63.
9. You WC, Brown LM, Zhang L, et al. A randomized factorial trial of Helicobacter pylori treatment and 7.3-year vitamin and garlic supplements to reduce precancerous gastric lesions in Linqu County, Shandong Province, China. J Natl Cancer Inst 2006;98:974-83.
10. Rifai N, Warnick GR. Quality specifications and the assessment of the biochemical risk of atherosclerosis. Clin Chim Acta 2004;345:55-64.
11. Mader FH. Treatment of hyperlipidaemia with garlic-powder tablets. Evidence from the German Association of General Practitioners' multicentric placebo-controlled double-blind study. Arzneimittelforschung 1990;40:1111-6.
12. DA Santos Os, Grunwald J. Effect of garlic powder tablets on blood lipids and blood pressure - a six-month placebo controlled double blind study. Br J Clin Res 1993;4:27-44.
13. Saradeth T, Seidl S, Resch K, et al. Does garlic alter the lipid pattern in normal volunteers? Phytomedicine 1994;1:183-5.
14. Wang S, Qian F. Geriatric cardiology. Beijing, China: People's Health Publishing House, 1998.
15. Carroll M, Lacher D, Sorlie P, et al. Trends in serum lipids and lipoproteins of adults, 1960-2002. JAMA 2005;294:1773-81.
16. Spigelski D, Jones PJ. Efficacy of garlic supplementation in lowering serum cholesterol levels. Nutr Rev 2001;59:236-41.
17. Hercberg S, Bertrais S, Czernichow S, et al. Alterations of the lipid profile after 7.5 years of low-dose antioxidant supplementation in the SU. VI. MAX study. Lipids 2005;40:335-42.
18. Howard DR, Rundell CA, Batsakis JG. Vitamin E does not modify HDL-Cholesterol. Am J Clin Pathol 1982;77:86-9.
19. Hallfrisch J, Singh VN, Muller C, et al. High plasma vitamin C associated with increased plasma LDL and HDL cholesterol. Am J Clin Nutr 1994;60:100-5.
20. Jacques PF. Relationships of vitamin C status to cholesterol and blood pressure. Ann N Y Acad Sci 1992;669:205-14.
21. Elwood PC, Hughes RE, Hurley RJ. Ascorbic acid and serum cholesterol. Lancet 1970;2:1197 (letter).
22. Jha P, Flather M, Lonn E, et al. The antioxidant vitamins and cardiovascular disease: a critical review of epidemiologic and clinical trial data. Ann Intern Med 1995;123:860-72.
23. Lee I, Cook N, Gaziano J, et al. Vitamin E in the primary prevention of cardiovascular disease and cancer. JAMA 2005;294:56-65.
24. Miller ER, Pastor- Barriuso R, Dalal D, et al. Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality. Ann Intern Med 2005;142:37-46.
25. Lonn E, Bosch J, Yusuf S, et al. Effects of long-term vitamin E supplementation on cardiovascular events and cancer. JAMA 2005;293:1338-47.
26. Hercberg S, Galan P, Preziosi P, et al. The SU. VI. MAX study. Arch Intern Med 2005;164:2335-42.
27. Elizalde JI, Pique JM, Moreno V, et al. Influence of Helicobacter pylori infection and eradication on blood lipids and fibrinogen. Aliment Pharmacol Ther 2002;16:577-87.