Microwave-assisted Friedländer synthesis of quinolines derivatives as potential antiparasitic agents

Tetrahedron Letters

Volumn 47, Issue 50, 2006, Pages 8811-8815

  Muscia, Gisela C ^a   Bollini, Mariela ^a   Carnevale, Juan P ^a   Bruno, Ana M ^a   Asís, Silvia E ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

Antiparasitic activity; Friedl nder quinolines; Microwave

Indexed keywords

ANTIPARASITIC AGENT; BENZNIDAZOLE; CHLOROQUINE; HYDROCHLORIC ACID; MELARSOPROL; MILTEFOSINE; PODOPHYLLOTOXIN; QUINOLINE DERIVATIVE; STIBOGLUCONATE SODIUM; SURAMIN; TAMOXIFEN;

AFRICAN TRYPANOSOMIASIS; ARTICLE; CATALYSIS; CONTROLLED STUDY; DRUG SYNTHESIS; IN VITRO STUDY; LEISHMANIASIS; MALARIA; MICROWAVE RADIATION; NONHUMAN; PLASMODIUM FALCIPARUM; SUBSTITUTION REACTION; TRYPANOSOMA CRUZI;

PLASMODIUM FALCIPARUM; TRYPANOSOMA CRUZI;

EID: 33750608059     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2006.10.073     Document Type: Article

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15. 50 is lower than 1 μg/mL, the compound is classified as active and is evaluated in a secondary screening.
16. Compound 4 was active at 50 mg/kg per ip route in a Chagas model (preliminary in vivo assay, WHO), under evaluation.