The Rx-like homeobox gene (Rx-L) is necessary for normal photoreceptor development

Investigative Ophthalmology and Visual Science

Volumn 47, Issue 10, 2006, Pages 4245-4253

  Pan, Yi ^a   Nekkalapudi, Srivamsi ^a   Kelly, Lisa E ^a   El Hodiri, Heithem M ^a,b  

^a OHIO STATE UNIVERSITY   (United States)

^b THE RESEARCH INSTITUTE AT NATIONWIDE CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIGOXIGENIN; MORPHOLINE; MORPHOLINO OLIGONUCLEOTIDE; OCTAPEPTIDE; OLIGONUCLEOTIDE; OPSIN; RHODOPSIN; UNCLASSIFIED DRUG; EYE PROTEIN; HOMEODOMAIN PROTEIN; TRANSCRIPTION FACTOR;

ANIMAL TISSUE; ARTICLE; BINDING SITE; CONTROLLED STUDY; DNA BINDING; EMBRYONAL TISSUE; GEL MOBILITY SHIFT ASSAY; GENE; GENE EXPRESSION; GENE FUNCTION; GENE REPRESSION; GENE SEQUENCE; HOMEOBOX; IN SITU HYBRIDIZATION; IN VITRO STUDY; ISOTOPE LABELING; NONHUMAN; OLIGONUCLEOTIDE PROBE; ORTHOPEDIA ARISTALESS RX DOMAIN; PHOTORECEPTOR; PRIORITY JOURNAL; RETINA DEVELOPMENT; RETINA ROD OUTER SEGMENT; RNA PROBE; RX L GENE; SEQUENCE HOMOLOGY; TRANSLATION INITIATION; XENOPUS LAEVIS; AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY; CYTOLOGY; GENE EXPRESSION REGULATION; GENETICS; IMMUNOHISTOCHEMISTRY; MOLECULAR GENETICS; PHYSIOLOGY; PRENATAL DEVELOPMENT; RETINA; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

AMINO ACID SEQUENCE; ANIMALS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; EYE PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HOMEODOMAIN PROTEINS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MOLECULAR SEQUENCE DATA; OLIGONUCLEOTIDE PROBES; PHOTORECEPTORS, VERTEBRATE; RETINA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY, AMINO ACID; TRANSCRIPTION FACTORS; XENOPUS LAEVIS;

EID: 33750603978     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.06-0167     Document Type: Article

References (48)

1. Zaghloul NA, Yan B, Moody SA. Step-wise specification of retinal stem cells during normal embryogenesis. Biol Cell. 2005;97:321-337.
2. Chow RL, Lang RA. Early eye development in vertebrates. Annu Rev Cell Dev Biol. 2001;17:255-296.
3. Marquardt T, Grass P. Generating neuronal diversity in the retina: one for nearly all. Trends Neurosci. 2002;25:32-38.
4. Marquardt T. Transcriptional control of neuronal diversification in the retina. Prog Retin Eye Res. 2003;22:567-577.
5. Zuber ME, Gestri G, Viczian AS, Barsacchi G, Harris WA. Specification of the vertebrate eye by a network of eye field transcription factors. Development. 2003;130:5155-5167.
6. Wawersik S, Maas RL. Vertebrate eye development as modeled in Drosophila. Hum Mol Genet. 12 2000;9:917-925.
7. Bailey TJ, El-Hodiri H, Zhang L, Shah R, Mathers PH, Jamrich M. Regulation of vertebrate eye development by Rx genes. Int J Dev Biol. 2004;48:761-770.
8. Mathers PH, Grinberg A, Mahon KA, Jamrich M. The Rx homeobox gene is essential for vertebrate eye development. Nature. 1997;387:603-607.
9. Chuang JC, Mathers PH, Raymond PA. Expression of three Rx homeobox genes in embryonic and adult zebrafish. Mech Dev. 1999;84:195-198.
10. Casarosa S, Andreazzoli M, Simeone A, Barsacchi G. Xrx1, a novel Xenopus homeobox gene expressed during eye and pineal gland development. Mech Dev. 1997;61:187-198.
11. Furukawa T, Kozak CA, Cepko CL. rax, a novel paired-type homeobox gene, shows expression in the anterior neural fold and developing retina. Proc Natl Acad Sci USA. 1997;94:3088-3093.
12. Chuang JC, Raymond PA. Zebrafish genes rx1 and rx2 help define the region of forebrain that gives rise to retina. Dev Biol. 2001;231:13-30.
13. Andreazzoli M, Gestri G, Angeloni D, Menna E, Barsacchi G. Role of Xrx1 in Xenopus eye and anterior brain development. Development. 1999;126:2451-2460.
14. Loosli F, Winkler S, Burgtorf C, et al. Medaka eyeless is the key factor linking retinal determination and eye growth. Development. 2001;128:4035-4044.
15. Voronina VA, Kozhemyakina EA, O'Kernick CM, et al. Mutations in the human RAX homeobox gene in a patient with anophthalmia and sclerocornea. Hum Mol Genet. 2004;13:315-322.
16. Tucker P, Laemle L, Munson A, et al. The eyeless mouse mutation (ey1) removes an alternative start codon from the Rx/rax homeobox gene. Genesis. 2001;31:43-53.
17. Loosli F, Staub W, Finger-Baier KC, et al. Loss of eyes in zebrafish caused by mutation of chokh/rx3. EMBO Rep. 2003;4:894-899.
18. Meijlink F, Beverdam A, Brouwer A, Oosterveen TC, Berge DT. Vertebrate aristaless-related genes. Int J Dev Biol. 1999;43:651-663.
19. Kimura A, Singh D, Wawrousek EF, Kikuchi M, Nakamura M, Shinohara T. Both PCE-1/RX and OTX/CRX interactions are necessary for photoreceptor-specific gene expression. J Biol Chem. 2000;275:1152-1160.
20. Mani SS, Batni S, Whitaker L, Chen S, Engbretson G, Knox BE. Xenopus rhodopsin promoter: identification of immediate upstream sequences necessary for high level, rod-specific transcription. J Biol Chem. 2001;276:36557-36565.
21. Batni S, Scalzetti L, Moody SA, Knox BE. Characterization of the Xenopus rhodopsin gene. J Biol Chem. 1996;271:3179-3186.
22. Moritz OL, Peck A, Tam BM. Xenopus laevis red cone opsin and Prph2 promoters allow transgene expression in amphibian cones, or both rods and cones. Gene. 2002;298:173-182.
23. Chen CM, Cepko CL. The chicken RaxL gene plays a role in the initiation of photoreceptor differentiation. Development 2002;129:5363-5375.
24. Wang QL, Chen S, Esumi N, et al. QRX, a novel homeobox gene, modulates photoreceptor gene expression. Hum Mol Genet. 2004;13:1025-1040.
25. Su CY, Iim J, Tsai HJ. Structural characterization and transcriptional pattern of two types of carp rhodopsin gene. Comp Biochem Physiol B Biochem Mol Biol. 2000;125:37-45.
26. Chen S, Wang QL, Nie Z, et al. Crx, a novel Otx-like paired-homeodomain protein, binds to and transactivates photoreceptor cell-specific genes. Neuron. 1997;19:1017-1030.
27. Whitaker SL, Knox BE. Conserved transcriptional activators of the Xenopus rhodopsin gene. J Biol Chem. 2004;279:49010-49018.
28. Rehemtulla A, Warwar R, Kumar R, Ji X, Zack DJ, Swaroop A. The basic motif-leucine zipper transcription factor Nrl can positively regulate rhodopsin gene expression. Proc Natl Acad Sci USA. 1996;93:191-195.
29. Mitton KP, Swain PK, Chen S, Xu S, Zack DJ, Swaroop A. The leucine zipper of NRL interacts with the CRX homeodomain: a possible mechanism of transcriptional synergy in rhodopsin regulation. J Biol Chem. 2000;275:29794-29799.
30. Ma GC, Wang TM, Su CY, Wang YL, Chen S, Tsai HJ. Retina-specific cis-elements and binding nuclear proteins of carp rhodopsin gene. FEBS Lett. 2001;508:265-271.
31. Ohuchi H, Tomonari S, Itoh H, Mikawa T, Noji S. Identification of chick rax/rx genes with overlapping patterns of expression during early eye and brain development. Mech Dev. 1999;85:193-195.
32. Sive HL, Grainger RM, Harland RM. Early Development of Xenopus laevis: A Laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press; 2000.
33. Krieg PA, Melton DA. In vitro RNA synthesis with SP6 RNA polymerase. Methods Enzymol. 1987;155:397-415.
34. Turner DL, Weintraub H. Expression of achaete-scute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate. Genes Dev. 1994;8:1434-1447.
35. Rubenstein A, Merriam J, Klymkowsky MW. Localizing the adhesive and signaling functions of plakoglobin. Dev Genet. 1997;20:91-102.
36. Li H, Tierney C, Wen L, Wu JY, Rao Y. A single morphogenetic field gives rise to two retina primordia under the influence of the prechordal plate. Development. 1997;124:603-615.
37. Kim SW, Fang X, Ji H, et al. Isolation and characterization of XKaiso, a transcriptional represser that associates with the catenin Xp120(ctn) in Xenopus laevis. J Biol Chem. 2002;277:8202-8208.
38. El-Hodiri HM, Shou W, Etkin LD. xnf7 functions in dorsal-ventral patterning of the Xenopus embryo. Dev Biol. 1997;190:1-17.
39. Viczian AS, Vignali R, Zuber ME, Barsacchi G, Harris WA. XOtx5b and XOtx2 regulate photoreceptor and bipolar fates in the Xenopus retina. Development. 2003;130:1281-1294.
40. Chang WS, Harris WA. Sequential genesis and determination of cone and rod photoreceptors in Xenopus. J Neurobiol. 1998;35:227-244.
41. Perron M, Harris WA. Retinal stem cells in vertebrates. Bioessays. 2000;22:685-688.
42. Johnson LV, Hageman GS, Blanks JC. Interphotoreceptor matrix domains ensheath vertebrate cone photoreceptor cells. Invest Ophthalmol Vis Sci. 1986;27:129-135.
43. Uehara F, Sameshima M, Muramatsu T, Ohba N. Localization of fluorescence-labeled lectin binding sites on photoreceptor cells of the monkey retina. Exp Eye Res. 1983;36:113-123.
44. Chen G, Courey AJ. Groucho/TLE family proteins and transcriptional repression. Gene. 2000;249:1-16.
45. Fisher AL, Caudy M. Groucho proteins: transcriptional corepressors for specific subsets of DNA-binding transcription factors in vertebrates and invertebrates. Genes Dev. 1998;12:1931-1940.
46. Galliot B, de Vargas C, Miller D. Evolution of homeobox genes: Q50 Paired-like genes founded the Paired class. Dev Genes Evol. 1999;209:186-197.
47. Dasen JS, Barbera JP, Herman TS, et al. Temporal regulation of a paired-like homeodomain repressor/TLE corepressor complex and a related activator is required for pituitary organogenesis. Genes Dev. 2001;15:3193-3207.
48. Molenaar M, Brian E, Roose J, devers H, Destree O. Differential expression of the Grouchorelated genes 4 and 5 during early development of Xenopus laevis. Mech Dev. 2000;91:311-315.