Effects of dibutylphthalate and ethynylestradiol on liver peroxisomes, reproduction, and development of zebrafish (Danio rerio)

Environmental Toxicology and Chemistry

Volumn 25, Issue 9, 2006, Pages 2394-2404

  Ortiz Zarragoitia, Maren ^a   Trant, John M ^b   Cajaraville, Miren P ^a  

^a UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^b UNIVERSITY OF MARYLAND BIOTECHNOLOGY INSTITUTE   (United States)

Author keywords

Aromatases; Gonad histology; Liver peroxisome proliferation; Vitellogenin; Zebrafish development

Indexed keywords

ALCOHOLS; BIOLOGICAL ORGANS; FISHERIES; GENETIC ENGINEERING; SYNTHESIS (CHEMICAL);

AROMATASES; GONAD HISTOLOGY; LIVER PEROXISOME PROLIFERATION; VITELLOGENIN; ZEBRAFISH DEVELOPMENT;

WATER POLLUTION;

AROMATASE; CYTOCHROME P450; ETHINYLESTRADIOL; PHTHALIC ACID DIBUTYL ESTER; VITELLOGENIN;

DEVELOPMENTAL STAGE; FISH; GENE EXPRESSION; MORTALITY; ORGANIC POLLUTANT; REPRODUCTION; TOXICITY;

ANIMAL EXPERIMENT; CONFERENCE PAPER; DEVELOPMENT; ENZYME SYNTHESIS; FEMALE; GENE EXPRESSION; INFERTILITY; MALE; MORPHOLOGY; NONHUMAN; PEROXISOME; PRIORITY JOURNAL; REPRODUCTION; SEX DETERMINATION; TERATOGENICITY; UPREGULATION; ZEBRA FISH; ANIMAL; ARTICLE; DRUG EFFECT; GENE EXPRESSION REGULATION; GROWTH, DEVELOPMENT AND AGING; LARVA; LIVER; METABOLISM; OOCYTE;

DANIO RERIO;

ANIMALS; DIBUTYL PHTHALATE; ETHINYL ESTRADIOL; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; LARVA; LIVER; MALE; OVUM; PEROXISOMES; REPRODUCTION; VITELLOGENINS; ZEBRAFISH;

EID: 33750597099     PISSN: 07307268     EISSN: None     Source Type: Journal    
DOI: 10.1897/05-456R.1     Document Type: Conference Paper

References (39)

1. World Health Organization/International Programme on Chemical Safety. 2002. Global assessment of the state-of-the-science of endocrine disrupters. WHO/IPCS/EDC/02.2. Geneva, Switzerland.
2. Goksøyr A, Arukwe A, Larsson J, Cajaraville MP, Hauser L, Nilsen BM, Lowe D, Matthiessen P. 2003. Chapter 3: Molecular/cellular processes and the impact on reproduction. In Lawrence AJ, Hemingway KL, eds, Effects of Pollution on Fish. Blackwell Science, Oxford, UK, pp 179-220.
3. Harris CA, Henttu P, Parker MG, Sumpter JP. 1997. The estrogenic activity of phthalate esters in vitro. Environ Health Perspect 105:802-811.
4. Jobling S, Reynolds T, White R, Parker MG, Sumpter JP. 1995. A variety of environmentally persistent chemicals, including some phthalate plasticizers, are weakly estrogenic. Environ Health Perspect 103:582-587.
5. Norrgren L, Blom A, Andersson PL, Börjeson H, Larsson DGJ, Olsson P-E. 1999. Effects of potential xenoestrogens (DEHP, nonylphenol, and PCB) on sexual differentiation in juvenile Atlantic salmon (Salmo salar). Aquat Ecosyst Health Manag 2:311-317.
6. Ortiz-Zarragoitia M, Cajaraville MP. 2005. Effects of selected xenoestrogens on liver peroxisomes, vitellogenin levels, and spermatogenic cell proliferation in male zebrafish. Comp Biochem Physiol Part C Toxicol Pharmacol 141:133-144.
7. Cajaraville MP, Cancio I, Ibabe A, Orbea A. 2003. Peroxisome proliferation as a biomarker in environmental pollution assessment. Microsc Res Tech 61:191-202.
8. Reddy JK, Lalwani ND. 1983. Carcinogenesis by hepatic peroxisome proliferators: Evaluation of the risk of hypolipidemic drugs and industrial plasticizers to humans. CRC Crit Rev Toxicol 12:1-58.
9. Keller H, Givel F, Perroud M, Wahli W. 1995. Signaling cross-talk between peroxisome proliferators-activated receptor/retinoid X receptor and estrogen receptor through estrogen-response elements. Mol Endocrinol 9:794-804.
10. Djouadi F, Weinheimer CJ, Saffitz JE, Pitchford C, Bastin J, González FJ, Kelly DP. 1998. A gender-related defect in lipid metabolism and glucose homeostasis in peroxisome proliferator-activated receptor α-deficient mice. J Clin Invest 102:1083-1091.
11. Mackintosh CE, Maldonado J, Hongwu J, Hoover N, Chong A, Ikonomou MG, Gobas FAPC. 2004. Distribution of phthalate esters in a marine aquatic food web: Comparison to polychlorinated biphenyls. Environ Sci Technol 38:2011-2020.
12. Devlin RH, Nagahama Y. 2002. Sex determination and sex differentiation in fish: An overview of genetic, physiological, and environmental influences. Aquaculture 208:191-364.
13. Callard GV, Tchoudakova A. 1997. Evolutionary and functional significance of two CYP19 genes differentially expressed in brain and ovary of goldfish. J Steroid Biochem Mol Biol 61:387-392.
14. Trant JM, Gavasso S, Ackers J, Chung BC, Place AR. 2001. Developmental expression of cytochrome P450 aromatase genes (CYP19a and CYP19b) in zebrafish fry (Danio rerio). J Exp Zool 290:475-483.
15. Williams DE, Lech JJ, Buhler DR. 1998. Xenobiotics and xenoestrogens in fish: Modulators of cytochrome P450 and carcinogenesis. Mutat Res 399:179-192.
16. Organization for Economic Cooperation and Development. 1998. OECD Guidelines for testing of chemicals: Fish. Short-term toxicity test on embryo and sac-fry stages, Section 2, Guideline 212. Paris, France.
17. Fatoki OS, Ogunfawokan AO. 1993. Determination of phthalate ester platicizers in the aquatic environment of southwestern Nigeria. Environ Int 19:619-623.
18. Small GM, Burdett K, Connock MJ. 1985. A sensitive spectrophotometric assay for peroxisomal acyl-CoA oxidase. Biochem J 227:205-210.
19. Orbea A, Beier K, Völkl A, Fahimi DH, Cajaraville MP. 1999. Ultrastructural, immunocytochemical, and morphometric characterization of liver peroxisomes in gray mullet (Mugil cephalus). Cell Tissue Res 297:493-502.
20. Braunbeck T, Storch V, Bresch H. 1990. Species-specific reaction of liver ultrastructure in zebrafish (Brachydanio rerio) and trout (Salmo gairdneri) after prolonged exposure to 4-chloroaniline. Arch Environ Contam Toxicol 19:405-418.
21. Cajaraville MP, Orbea A, Marigómez I, Cancio I. 1997. Peroxisome proliferation in the digestive epithelium of mussels exposed to the water accommodated fraction of three oils. Comp Biochem Physiol C: Toxicol Pharmacol 117:233-242.
22. Martoja R, Martoja-Pierson M. 1970. Técnicas De Histología Animal. Toray-Masson, Barcelona, Spain.
23. Kazeto Y, Place AR, Trant JM. 2004. Effects of endocrine-disrupting chemicals on the expression of CYP19 genes in zebrafish (Danio rerio) juveniles. Aquat Toxicol 69:25-34.
24. Kishida M, Callard GV. 2001. Distinct cytochrome P450 aromatase isoforms in zebrafish (Danio rerio) brain and ovary are differentially programmed and estrogen regulated during early development. Endocrinology 142:740-750.
25. Callard GV, Petro Z, Ryan KJ, Clairbone JB. 1981. Estrogen synthesis in vitro and in vivo in the brain of a marine teleost (Myoxocephalus). Gen Comp Endocrinol 43:243-255.
26. Van den Belt K, Verheyen R, Witters H. 2003. Effects of 17α-ethynylestradiol in a partial life-cycle test with zebrafish (Danio rerio): Effects on growth, gonads, and female reproductive success. Sci Total Environ 309:127-137.
27. Weber LP, Hill RL, Janz DM. 2003. Developmental estrogenic exposure in zebrafish (Danio rerio): II. Histological evaluation of gametogenesis and organ toxicity. Aquat Toxicol 63:431-446.
28. Islinger M, Willimski D, Völkl A, Braunbeck T. 2003. Effects of 17α-ethynylestradiol on the expression of three estrogen-responsive genes and cellular ultrastructure of liver and testes in male zebrafish. Aquat Toxicol 62:85-103.
29. Wong JS, Gill SS. 2002. Gene expression changes induced in mouse liver by di(2-ethylhexyl)phthalate. Toxicol Appl Pharmacol 185:180-196.
30. Lovekamp-Swan T, Davis B. 2003. Mechanisms of phthalate ester toxicity in the female reproductive system. Environ Health Perspect 111:139-145.
31. Pawlowski S, van Aerle R, Tyler CR, Braunbeck T. 2004. Effects of 17α-ethynylestradiol in a fathead minnow (Pimephales promelas) gonadal recrudescence assay. Ecotoxicol Environ Saf 57:330-345.
32. Ibabe A, Herrero A, Cajaraville MP. 2005. Modulation of peroxisome proliferator-activated receptors (PPARs) by PPARα- and PPARγ-specific ligands and by 17β-estradiol in isolated zebrafish hepatocytes. Toxicol In Vitro 19:725-735.
33. Van der Yen LTM, Holbech H, Fenske M, Van den Brandhof E-J, Gielis-Proper FK, Wester PW. 2003. Vitellogenin expression in zebrafish Danio rerio: Evaluation by histochemistry, immunohistochemistry, and in situ mRNA hybridization. Aquat Toxicol 65:1-11.
34. Hemmer MJ, Bowman CJ, Hemmer BL, Friedman SD, Markovich D, Kroll KJ, Denslow ND. 2002. Vitellogenin mRNA regulation and plasma clearance in male sheepshead minnows (Cyprinodon variegatus) after cessation of exposure to 17β-estradiol and p-nonylphenol. Aquat Toxicol 58:99-112.
35. Chiang EF-L, Yan Y-L, Guiguen Y, Postlethwait J, Chung B-C. 2001. Two Cyp19 (P450 aromatase) genes on duplicated zebrafish chromosomes are expressed in ovary or brain. Mol Biol Evol 18:542-550.
36. Kazeto Y, Ijiri S, Place AR, Zohar Y, Trant JM. 2001. The 5′-flanking regions of CYP19A1 and CYP19A2 in zebrafish. Biochem Biophys Res Commun 288:503-508.
37. Liu RCM, Hahn C, Hunt ME. 1996. The direct effect of hepatic peroxisome proliferators on rat Leydig cell function in vitro. Fundam Appl Toxicol 30:102-108.
38. Fan LQ, Cattley RC, Corton JC. 1998. Tissue-specific induction of 17β-hydroxysteroid dehydrogenase type IV by peroxisome proliferator chemicals is dependent on the peroxisome proliferator-activated receptor α. J Endocrinol 158:237-246.
39. Sepulveda MS, Quinn BP, Denslow ND, Holm SE, Gross TS. 2003. Effects of pulp and paper mill effluents on reproductive success of largemouth bass. Environ Toxicol Chem 22:205-213.