Pharmacokinetics of cefovecin in cats

Journal of Veterinary Pharmacology and Therapeutics

Volumn 29, Issue 6, 2006, Pages 513-524

  Stegemann, M R ^a   Sherington, J ^a   Coati, N ^a   Brown, S A ^b   Blanchflower, S ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAS 141195 77 9; CEFOVECIN; CEPHALOSPORIN DERIVATIVE; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ANIMAL EXPERIMENT; ARTICLE; BIOAVAILABILITY; CAT; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG EXCRETION; DRUG HALF LIFE; FEMALE; MALE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; URINARY EXCRETION;

ANIMALS; ANTI-BACTERIAL AGENTS; AREA UNDER CURVE; CATS; CEPHALOSPORINS; CROSS-OVER STUDIES; FEMALE; INFUSIONS, INTRAVENOUS; INJECTIONS, SUBCUTANEOUS; MALE; MICROBIAL SENSITIVITY TESTS; PASTEURELLA MULTOCIDA;

FELIDAE; PASTEURELLA MULTOCIDA;

EID: 33750575330     PISSN: 01407783     EISSN: 13652885     Source Type: Journal    
DOI: 10.1111/j.1365-2885.2006.00795.x     Document Type: Article

References (30)

1. Barter, L.S., Watson, A.D. & Maddison, J.E. (1996) Owner compliance with short term antimicrobial medication in dogs. Australian Veterinary Journal, 74, 277-280.
2. Bidgood, T.L. & Papich, M.G. (2005) Plasma and interstitial fluid pharmacokinetics of enrofloxacin, its metabolite ciprofloxacin and marbofloxcin after oral administration and a constant rate intravenous infusion in dogs. Journal of Veterinary Pharmacology and Therapeutics, 28, 329-341.
3. Bomzon, L. (1978) Short-term antimicrobial therapy - a pilot compliance study using ampicillin in dogs. Journal of Small Animal Practice, 19, 697-700.
4. Clarke, C.R., Brown, S.A., Streeter, R.N., Clarke, J.M., Hamlow, P.J., Callahan, J.K., Hubbard, V.L., Speedy, A.K. & Burrows, G.E. (1996) Penetration of parenterally administered ceftiofur into sterile vs. Pasteurella haemolytica-infected tissue chambers in cattle. Journal of Veterinary Pharmacology and Therapeutics, 19, 376-381.
5. Craig, W.A. (1995) Interrelationship between pharmacokinetics and pharmacodynamics in determining dosage regimens for broad-spectrum cephalosporins. Diagnostic Microbiology and Infectious Diseases, 22, 89-96.
6. Craig, W.A. (2003) Basic pharmacodynamics of antibacterials with clinical applications to the use of b-lactams, glycopeptides, and linezolid. Infectious Disease Clinics of North America, 17, 479-501.
7. Crosse, R. & Burt, D.G. (1984) Antibiotic concentration in the serum of dogs and cats following a single oral dose of cephalexin. Veterinary Record, 115, 106-107.
8. Daniel, H. & Kottra, G. (2004) The proton oligopeptide cotransporter family SLC15 in physiology and pharmacology. Pflugers Archives European Journal of Physiology, 447, 610-618.
9. Ganapathy, M.E., Huang, W., Rajan, D.P., Carter, A.L., Sugawara, M., Iseki, K., Leibach, F.H. & Ganapathy, V. (2000) β Lactam antibiotics as substrates for OCTN2, an organic cation/carnitine transporter. Journal of Biological Chemistry, 275, 1699-1707.
10. Ganiere, J.P., Medaille, C. & Mangion, C. (2005) Antimicrobial drug susceptibility of Staphylococcus intermedius clinical isolates from canine pyoderma. Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health, 52, 25-31.
11. Grave, K. & Tanem, H. (1999) Compliance with short-term oral antibacterial drug treatment in dogs. Journal of Small Animal Practice, 40, 158-162.
12. Leggett, J., Fantin, B., Ebert, S., Totsuka, K., Vogelman, B., Calame, W., Mattie, H. & Craig, W. (1989) Comparative antibiotic dose-effect relations at several dosing intervals in murine pneumonitis and thigh-infection models. Journal of Infectious Diseases, 159, 281-292.
13. Ling, G.V. & Ruby, A.L. (1983) Cephalexin for oral treatment of canine urinary tract infection caused by Klebsiella pneumoniae. Journal of the American Veterinary Medical Association, 182, 1346-1347.
14. Luckner, P. & Brandsch, M. (2005) Interaction of 31 β lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1. European Journal of Pharmaceutics and Biopharmaceutics, 59, 17-24.
15. Lutsar, I. & Friedland, I.R. (2000) Pharmacokinetics and pharmacodynamics of cephalosporins in cerebrospinal fluid. Clinical Pharmacokinetics, 39, 335-343.
16. Normand, E.H., Gibson, N.R., Taylor, D.J., Carmichael, S. & Reid, S.W. (2000) Trends of antimicrobial resistance in bacterial isolates from a small animal referral hospital. Veterinary Record, 146, 151-155.
17. OECD (1998) Organisation for Economic Co-operation and Development: Environment Directorate - OECD. Principles of Good Laboratory Practice, OECD, Paris, France.
18. Papich, M.G. (1984) Clinical pharmacology of cephalosporin antibiotics. Journal of the American Veterinary Medical Association, 184, 344-347.
19. Ringger, N.C., Pearson, E.G., Gronwall, R. & Kohlepp, S.J. (1996) Pharmacokinetics of ceftriaxone in healthy horses. Equine Veterinary Journal, 28, 476-479.
20. Rosin, E., Uphoff, T.S., Schultz-Darken, N.J. & Collins, M.T. (1993) Cefazolin antibacterial activity and concentrations in serum and the surgical wound in dogs. American Journal of Veterinary Research, 54, 1317-1321.
21. Seltzer, E., Dorr, M.B., Goldstein, B.P., Perry, M., Dowell, J.A. & Henkel, T. (2003) Once-weekly dalbavancin versus standard-of-care antimicrobial regimens for treatment of skin and soft-tissue infections. Clinical Infectious Diseases, 37, 1298-1303.
22. Shojaee, A.F., Landoni, M.F. & Lees, P. (2003) Pharmacokinetics (PK), pharmacodynamics (PD), and PK-PD integration of danofloxacin in sheep biological fluids. Antimicrobial Agents and Chemotherapy, 47, 626-635.
23. Silley, P., Rudd, A.P., Symington, W.M. & Tait, A.J. (1988) Pharmacokinetics of cephalexin in dogs and cats after oral, subcutaneous and intramuscular administration. Veterinary Record, 122, 15-17.
24. Soraci, A.L., Mestorino, O.N. & Errecalde, J.O. (1996) Pharmacokinetics of cefoperazone in horses. Journal of Veterinary Pharmacology and Therapeutics, 19, 39-43.
25. Stegemann, M.R., Passmore, C.A., Sherington, J., Lindeman, C.J., Papp, G., Weigl, D.J. & Skogerboe, T.L. (2006a) Antimicrobial activity and spectrum of cefovecin, a new extended spectrum cephalosporin, against pathogens collected from dogs and cats in Europe and North America. Antimicrobial Agents and Chemotherapy, 50, 2286-2292.
26. Stegemann, M., Sherington, J. & Blanchflower, S. (2006b) Pharmacokinetics and pharmacodynamics of cefovecin in dogs. Journal of Veterinary Pharmacology and Therapeutics, 29, 501-511.
27. Thomson, T.D., Quay, J.F. & Webber, J.A. (1984) Cephalosporin group of antimicrobial drugs. Journal of the American Veterinary Medical Association, 185, 1109-1114.
28. VICH (2000) International Co-operation on Harmonisation of Technical Requirements for Registration of Veterinary Medicinal Products, Good Clinical Practice, June 2000 effective 01 July 2001. VICH (Veterinary International Co-operation on Harmonisation). Available from http:// www.vich.eudra.org.
29. Vogelman, B., Gudmundsson, S., Leggett, J.E., Turnidge, J., Ebert, S. & Craig, W.A. (1988) Correlation of antimicrobial pharmacokinetics parameters with therapeutic efficacy in an animal model. Journal of Infectious Diseases, 158, 831-847.
30. Walker, R.D., Stein, G.E., Hauptman, J.G. & MacDonald, K.H. (1992) Pharmacokinetic evaluation of enrofloxacin administered orally to healthy dogs. American Journal of Veterinary Research, 53, 2315-2319.