Preceding immunosuppressive therapy with antithymocyte globulin and ciclosporin increases the incidence of graft rejection in children with aplastic anaemia who underwent allogeneic bone marrow transplantation from HLA-identical siblings

British Journal of Haematology

Volumn 135, Issue 5, 2006, Pages 693-696

  Kobayashi, Ryoji ^a   Yabe, Hiromasa ^b   Hara, Junichi ^c   Morimoto, Akira ^d   Tsuchida, Masahiro ^e   Mugishima, Hideo ^f   Ohara, Akira ^g   Tsukimoto, Ichiro ^g   Kato, Koji ^h   Kigasawa, Hisato ⁱ   Tabuchi, Ken ⁱ   Nakahata, Tatsutoshi ^j   Ohga, Shoichi ^k   Kojima, Seiji ^l  

^a HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c Higashi Osaka City Central Hospital   (Japan)

^d KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^e Ibaraki Children's Hospital   (Japan)

^f NIHON UNIVERSITY   (Japan)

^g TOHO UNIVERSITY   (Japan)

^h JAPANESE RED CROSS NAGOYA FIRST HOSPITAL   (Japan)

ⁱ KANAGAWA CHILDREN'S MEDICAL CENTER   (Japan)

^j KYOTO UNIVERSITY   (Japan)

^k KYUSHU UNIVERSITY   (Japan)

^l NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

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Author keywords

Aplastic anaemia; Bone marrow transplantation; Childhood; Immunosuppressive therapy

Indexed keywords

CYCLOSPORIN A; THYMOCYTE ANTIBODY;

ADULT; ALLOGENIC BONE MARROW TRANSPLANTATION; APLASTIC ANEMIA; ARTICLE; CHILD; CHILDHOOD DISEASE; GRAFT REJECTION; HLA SYSTEM; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; INFANT; MAJOR CLINICAL STUDY; MULTIVARIATE ANALYSIS; NEWBORN; PRIORITY JOURNAL; RISK FACTOR; SIBLING; TREATMENT FAILURE;

ADOLESCENT; ANEMIA, APLASTIC; ANTILYMPHOCYTE SERUM; ANTINEOPLASTIC AGENTS; BONE MARROW TRANSPLANTATION; CHILD; CHILD, PRESCHOOL; CYCLOSPORINE; FEMALE; GRAFT REJECTION; HUMANS; INCIDENCE; INFANT; INFANT, NEWBORN; MALE; RISK FACTORS; SIBLINGS; STATISTICS, NONPARAMETRIC; SURVIVAL RATE; TRANSPLANTATION CONDITIONING; TRANSPLANTATION, ISOGENEIC; TREATMENT FAILURE;

EID: 33750542315     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2006.06352.x     Document Type: Article

References (6)

1. Ades, L, Mary, JY, Robin, M, Ferry, C, Porcher, R, Esperou, H, Ribaud, P, Devergie, A, Traineau, R, Gluckman, E, Socie, G. (2004) Long-term outcome after bone marrow transplantation for severe aplastic anemia. Blood, 103, 2490-2497.
2. Camitta, BM, Thomas, ED, Nathan, DG, Gale, RP, Kopecky, KJ, Rappeport, JM, Santos, G, Gordon-Smith, EC, Storb, R. (1979) A prospective study of androgens and bone marrow transplantation for treatment of severe aplastic anemia. Blood, 53, 504-514.
3. Fuhrer, M, Rampf, U, Baumann, I, Faldum, A, Niemeyer, C, Janka-Schaub, G, Friedrich, W, Ebell, W, Borkhardt, A, Bender-Goetze, C. (2005) Immunosuppressive therapy for aplastic anemia in children: a more severe disease predicts better survival. Blood, 106, 2102-2104.
4. Hoelle, W, Beck, JF, Dueckers, G, Kreyenberg, H, Lang, P, Gruhn, B, Fuhrer, M, Niethammer, D, Klingebiel, T, Bader, P. (2004) Clinical relevance of serial quantitative analysis of hematopoietic chimerism after allogeneic stem cell transplantation in children for severe aplastic anemia. Bone Marrow Transplantation, 33, 219-223.
5. Kojima, S, Hibi, S, Kosaka, Y, Yamamoto, M, Tsuchida, M, Mugishima, H, Sugita, K, Yabe, H, Ohara, A, Tsukimoto, I. (2000) Immunosuppressive therapy using antithymocyte globulin, cyclosporin, and danazol with or without human granulocyte colony-stimulating factor in children with acquired aplastic anemia. Blood, 96, 2049-2054.
6. Lawlor, ER, Anderson, RA, Davis, JH, Fryer, CJ, Pritchard, SL, Rogers, PC, Wu, JK, Schultz, KR. (1997) Immunosuppressive therapy: a potential alternative to bone marrow transplantation as initial therapy for acquired severe aplastic anemia in childhood? Journal of Pediatric Hematology and Oncology, 19, 115-123.