Isolated prolonged activated partial thromboplastin time in an asymptomatic patient: Fletcher factor deficiency

Thrombosis Research

Volumn 118, Issue 6, 2006, Pages 765-766

  Acar, Kadir ^a   Yaǧci, Münci ^a   Sucak, Gülsan Türköz ^a   Haznedar, Rauf ^a  

^a GAZI UNIVERSITY FACULTY OF MEDICINE   (Turkey)

Author keywords

Fletcher factor; Prekallikrein; Prolonged activated partial thromboplastin time

Indexed keywords

BLOOD CLOTTING FACTOR 11; BLOOD CLOTTING FACTOR 12; BLOOD CLOTTING FACTOR 12A; BLOOD CLOTTING FACTOR 7; CYSTEINE PROTEINASE; HIGH MOLECULAR WEIGHT KININOGEN; KININ; PREKALLIKREIN; THROMBOPLASTIN;

AUTOSOMAL RECESSIVE INHERITANCE; BLEEDING TIME; BLOOD CLOTTING; BLOOD CLOTTING DISORDER; DIFFERENTIAL DIAGNOSIS; FIBRINOLYSIS; HUMAN; INCUBATION TEMPERATURE; INCUBATION TIME; LETTER; PARTIAL THROMBOPLASTIN TIME; PREKALLIKREIN DEFICIENCY; PRIORITY JOURNAL; THROMBOEMBOLISM;

AGED; BLOOD COAGULATION DISORDERS, INHERITED; FEMALE; HUMANS; PARTIAL THROMBOPLASTIN TIME; PREKALLIKREIN;

EID: 33750532272     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.thromres.2005.12.003     Document Type: Letter

References (9)

1. Yarovaya G.A., Blokhina T.B., and Neshkova E.A. Contact system. New concepts on activation mechanisms and bioregulatory functions. Biochemistry 67 (2002) 13-24
2. Kitchens C.S. The contact system. Arch Pathol Lab Med 126 (2002) 1382-1386
3. Tans G., and Griffin J.H. Properties of sulfatides in factor-XII-dependent contact activation. Blood 59 (1982) 69-75
4. Colman R.W. Biologic activities of the contact factors in vivo; potentiation of hypotension, inflammation, and fibrinolysis, and inhibition of cell adhesion, angiogenesis and thrombosis. Thromb Haemost 82 (1999) 1568-1577
5. Roberts H.R., Monroe III D.M., and Hoffman M. Molecular biology and biochemistry of the coagulation factors and pathway of hemostasis. In: Beutler E., Lichtman M.A., Coller B.S., Kipps T.J., and Seligsohn U. (Eds). Williams hematology. 6th edition (2001), Mc Graw-Hill, New York 1409-1434
6. Hataway W.E., Belhasen L.P., and Hataway H.S. Evidence for a new plasma thromboplastin factor: I. Case report, coagulation studies and physiochemical properties. Blood 26 (1965) 521-532
7. Saito H., Goodnough L.T., Soria J., Soria C., Anzar J., and Espana F. Heterogeneity of human prekallikrein deficiency (Fletcher trait); evidence that five of 18 cases are positive for cross-reacting material. N Engl J Med 305 (1981) 910-914
8. Yu H., Anderson P.J., Freedman B.I., Rich S.S., and Bowden D.W. Genomic structure of the human plasma prekallikrein gene, identification of allelic variants, and analysis in end-stage renal disease. Genomics 69 (2000) 225-234
9. Asmis L.M., Sulzer I., Furlan M., and Lammle B. Prekallikrein deficiency: the characteristic normalization of the severely prolonged aPTT following increased preincubation time is due to autoactivation of factor XII. Thromb Res 105 (2002) 463-470