Inhibitors of unactivated p38 MAP kinase

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 23, 2006, Pages 6102-6106

  Bullington, James ^a   Argentieri, Dennis ^a   Averill, Kristin ^a   Carter, Demetrius ^a   Cavender, Druie ^a   Fahmy, Bohumila ^a   Fan, Xiaodong ^a   Hall, Daniel ^a   Heintzelman, Geoffrey ^a   Jackson, Paul ^a   Leung, Wai Ping ^b   Li, Xun ^a   Ling, Ping ^b   Olini, Gilbert ^a   Razler, Thomas ^a   Reuman, Michael ^a   Rupert, Kenneth ^a   Russell, Ronald ^a   Siekierka, John ^a   Wadsworth, Scott ^a   Wolff, Russell ^a   Xiang, Bangping ^a   Zhang, Yue Mei ^a   more..

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

^b LLC   (United States)

Author keywords

Kinase; p38; Pyrrole; TNF; Toxicity

Indexed keywords

ADJUVANT; COLLAGEN; CYTOCHROME P450; IMIDAZOLE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; PIPERAZINE DERIVATIVE; TUMOR NECROSIS FACTOR;

ADJUVANT ARTHRITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTHRITIS; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SYNTHESIS; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; IC 50; MOUSE; NONHUMAN;

ANIMALS; ENZYME INHIBITORS; ESTERS; MICE; MOLECULAR STRUCTURE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PIPERAZINES; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR NECROSIS FACTOR-ALPHA;

EID: 33750526440     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.08.101     Document Type: Article

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