Controversy in Heart Failure Management: Digoxin Use in the Elderly

Journal of the American Medical Directors Association

Volumn 7, Issue 9, 2006, Pages 581-586

  Chun, Jeremy ^a   Chodosh, Joshua ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b VA GREATER LOS ANGELES HEALTHCARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDOSTERONE ANTAGONIST; AMIODARONE; ANGIOTENSIN RECEPTOR ANTAGONIST; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; DIGOXIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; ERYTHROMYCIN; PLACEBO; QUINIDINE; TETRACYCLINE;

AGED; ANOREXIA; ARTICLE; CLINICAL TRIAL; DELIRIUM; DRUG BLOOD LEVEL; DRUG INDICATION; DRUG INTOXICATION; DRUG MECHANISM; DRUG RESPONSE; DRUG SAFETY; DRUG USE; DRUG WITHDRAWAL; EVIDENCE BASED PRACTICE; GASTROINTESTINAL SYMPTOM; HEART FAILURE; HEART MUSCLE CONDUCTION DISTURBANCE; HUMAN; NURSING HOME; PRACTICE GUIDELINE; SEX DIFFERENCE; VISUAL DISORDER;

EID: 33750522040     PISSN: 15258610     EISSN: 15389375     Source Type: Journal    
DOI: 10.1016/j.jamda.2006.08.010     Document Type: Article

References (35)

1. American Heart Association. Heart Disease and Stroke Statistics. 2006 Update (2006), American Heart Association, Dallas, TX
2. Kannel W.B., and Belanger A.J. Epidemiology of heart failure. Am Heart J 121 (1991) 951-957
3. Avorn J., and Gurwitz J.H. Drug use in the nursing home. Arch Intern Med 123 (1995) 195-204
4. Tobias D.E., and Sey M. General and psychotherapeutic medication use in 328 nursing facilities: A year 2000 national survey. Consult Pharm 16 (2001) 54-64
5. Massie B.M., and Shah N.B. Evolving trends in the epidemiologic factors of heart failure: Rationale for preventive strategies and comprehensive disease management. Am Heart J 133 (1997) 703-712
6. Jessup M., and Brozena S. Heart failure. N Engl J Med 348 (2003) 2007-2018
7. Dec G.W. Digoxin remains useful in the management of chronic heart failure. Med Clin North Am 87 (2003) 317-337
8. Prystowsky E.N., Benson Jr. D.W., Fuster V., et al. Management of patients with atrial fibrillation. A statement for healthcare professionals. From the Subcommittee on Electrocardiography and Electrophysiology, American Heart Association. Circulation 93 (1996) 1262-1277
9. Hood W.B., Dans A.L., Guyatt G.H., Jaeschke R., and McMurray J.J.V. Digitalis for treatment of congestive heart failure in patients in sinus rhythm. Cochrane Database Syst Rev 2 (2004) CD002901
10. Tresch D.D., and McGough M.F. Heart failure with normal systolic function: A common disorder in older people. J Am Geriatr Soc 43 (1995) 1035-1042
11. Boxer R., Yang S.X., and Hager W.D. Congestive heart failure and the elderly. Conn Med 67 (2003) 497-503
12. ACC/AHA 2005 guideline update for the diagnosis and management of chronic heart failure in the adult: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Update the 2001 Guidelines for the Evaluation and Management of Heart Failure). J Am Coll Cardiol 46 (2005) e1-e82
13. The Digitalis Investigation Group. The effect of digoxin on mortality and morbidity in patients with heart failure. N Engl J Med 336 (1997) 525-533
14. Rich M.W., McSherry F., Williford W.O., Yusuf S., and Digitalis Investigation Group. Effect of age on mortality, hospitalizations and response to digoxin in patients with heart failure: The DIG study. J Am Coll Cardiol 38 (2001) 806-813
15. Uretsky B.F., Young J.B., Shahidi F.E., Yellen L.G., Harrison M.C., Jolly M.K., and PROVED Investigative Group. Randomized study assessing the effect of digoxin withdrawal in patients with mild to moderate chronic congestive heart failure: Results of the PROVED trial. J Am Coll Cardiol 22 (1993) 955-962
16. Packer M., Gheorghiade M., Young J.B., et al. Withdrawal of digoxin from patients with chronic heart failure treated with angiotensin-converting-enzyme inhibitors. RADIANCE Study. N Engl J Med 329 (1993) 1-7
17. Rathore S.S., Wang Y., and Krumholz H.M. Sex-based differences in the effect of digoxin for the treatment of heart failure. N Engl J Med 347 (2002) 1403-1411
18. Ahmed A., Aronow W.S., and Fleg J.L. Predictors of mortality and hospitalization in women with heart failure in the Digitalis Investigation Group trial. Am J Ther 13 (2006) 325-331
19. Adams Jr. K.F., Patterson J.H., Gattis W.A., et al. Relationship of serum digoxin concentration to mortality and morbidity in women in the Digitalis Investigation Group trial: a retrospective analysis. J Am Coll Cardiol 46 (2005) 497-504
20. Ahmed A., Aban I.B., Weaver M.T., Aronow W.S., and Fleg J.L. Serum digoxin concentration and outcomes in women with heart failure: A bi-directional effect and a possible effect modification by ejection fraction. Eur J Heart Fail 8 (2006) 409-419 Epub Nov 28, 2005
21. El-Salawy S.M., Lowenthal D.T., Ippagunta S., and Bhinder F. Clinical Pharmacology and Physiology Conference: Digoxin toxicity in the elderly. Int Urol Nephrol 37 (2005) 665-668
22. Aronow W.S. Treatment of systolic and diastolic heart failure in the elderly. J Am Med Dir Assoc 7 (2006) 29-36 Epub Oct 24, 2005
23. Eisendrath S.J., and Sweeney M.A. Toxic neuropsychiatric effects of digoxin at therapeutic serum concentrations. Am J Psychiatry 144 (1987) 506-507
24. Dimant J., and Merrit W. Serum digoxin levels in elderly nursing home patients: Appraisal of routine periodic measurements. J Am Geriatr Soc 26 (1978) 378-379
25. Adams Jr. K.F., Gheorghiade M., Uretsky B.F., Patterson J.H., Schwartz T.A., and Young J.B. Clinical benefits of low serum digoxin concentrations in heart failure. J Am Coll Cardiol 39 (2002) 946-953
26. Ware J.A., Snow E., Luchi J.M., and Luchi R.J. Effect of digoxin on ejection fraction in elderly patients with congestive heart failure. J Am Geriatr Soc 32 (1984) 631-635
27. Rathore S.S., Curtis J.P., Wang Y., Bristow M.R., and Krumholz H.M. Association of serum digoxin concentration and outcomes in patients with heart failure. JAMA 289 (2003) 871-878
28. Misiaszek B., Heckman G.A., Merali F., et al. Digoxin prescribing for heart failure in elderly residents of long-term care facilities. Can J Cardiol 21 (2005) 281-286
29. Aronow W.S. Prevalence of appropriate and inappropriate indications for use of digoxin in older patients at the time of admission to a nursing home. J Am Geriatr Soc 44 (1996) 588-590
30. Ahmed A., Rich M.W., Fleg J.L., et al. Effects of digoxin on morbidity and mortality in diastolic heart failure: The ancillary digitalis investigation group trial. Circulation 114 (2006) 397-403 Epub Jul 24, 2006
31. Aronow W.S. Epidemiology, pathophysiology, prognosis, and treatment of systolic and diastolic heart failure. Cardiol Rev 14 (2006) 108-124
32. Forman D.E., Coletta D., Kenny D., et al. Clinical issues related to discontinuing digoxin therapy in elderly nursing home patients. Arch Intern Med 151 (1991) 2194-2198
33. Wilkins C.E., and Khurana M.S. Digitalis withdrawal in elderly nursing home patients. J Am Geriatr Soc 33 (1985) 850-851
34. Macarthur C. Withdrawal of maintenance digoxin from institutionalized elderly. Postgrad Med J 66 (1990) 940-942
35. Fonrose H.A., Ahlbaum N., Bugatch E., Cohen M., Genovese C., and Kelly J. The efficacy of digitalis withdrawal in an institutional aged population. J Am Geriatr Soc 22 (1974) 208-211