Monitoring salivary lamotrigine concentrations

Journal of Clinical Neuroscience

Volumn 13, Issue 9, 2006, Pages 902-907

  Malone, Stephen A ^a,b   Eadie, Mervyn J ^b   Addison, Russell S ^b   Wright, Andrew W E ^b   Dickinson, Ronald G ^b  

^a ROYAL CHILDREN'S HOSPITAL   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Antiepileptic drugs; Lamotrigine; Salivary drug concentrations; Therapeutic drug monitoring

Indexed keywords

LAMOTRIGINE;

ADOLESCENT; ANTICONVULSANT THERAPY; ARTICLE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG BLOOD LEVEL; DRUG MONITORING; DRUG SALIVA LEVEL; EPILEPSY; HUMAN; PLASMA; PRIORITY JOURNAL; SALIVATION;

ADOLESCENT; ADULT; ANTICONVULSANTS; BIOLOGICAL ASSAY; CHILD; CHILD, PRESCHOOL; DRUG ADMINISTRATION SCHEDULE; EPILEPSY; FEMALE; HUMANS; INFANT; MALE; MIDDLE AGED; MONITORING, PHYSIOLOGIC; PLASMA; SALIVA; TIME FACTORS; TRIAZINES;

EID: 33750517087     PISSN: 09675868     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jocn.2005.12.037     Document Type: Article

References (17)

1. Bochner F., Hooper W.D., Sutherland J.M., et al. Diphenylhydantoin concentrations in saliva. Arch Neurol 31 (1974) 57-59
2. McAuliffe J.J., Sherwin A.L., Leppik I.E., et al. Salivary levels of anticonvulsants: a practical approach to drug monitoring. Neurology 27 (1977) 409-413
3. Liu H., and Delgado M.R. Therapeutic drug concentration monitoring using saliva samples: focus on anticonvulsants. Clin Pharmacokinet 36 (1999) 453-470
4. Knott C., and Reynolds F. The place of saliva in antiepileptic drug monitoring. Ther Drug Monit 6 (1984) 35-41
5. Gorodischer R., Burtin P., Verjee Z., et al. Is saliva suitable for therapeutic monitoring of anticonvulsants in children: an evaluation in the routine clinical setting. Ther Drug Monit 19 (1997) 637-642
6. Horning M.G., Brown L., Nowlin J., et al. Use of saliva in therapeutic drug monitoring. Clin Chemistry 23 (1977) 157-164
7. Tsiropouolos I., Kristensen O., and Klitgaard N.A. Saliva and serum concentration of lamotrigine in patients with epilepsy. Ther Drug Monit 22 (2000) 517-521
8. Trnavska Z., Krejcova H., Tkaczykovam S.Z., et al. Pharmacokinetics of lamotrigine (Lamictal) in plasma and saliva. Eur J Drug Metab Pharmacokinet Spec. No.3 (1991) 211-215
9. Ryan M., Grim S.A., Miles M.V., et al. Correlation of lamotrigine concentrations between serum and saliva. Pharmacotherapy 23 (2003) 1550-1557
10. Grim S.A., Ryan M., Miles M.V., et al. Correlation of levetiracetam concentrations between serum and saliva. Ther Drug Monit 25 (2003) 61-66
11. Berry D.J., Beran R.G., Plunkeft M.J., et al. The absorption of gabapentin following high dose escalation. Seizure 12 (2003) 28-36
12. Benetello P., Ferlanut M., Fortunato M., et al. Oral gabapentin disposition in patients with epilepsy after a high protein meal. Epilepsia 38 (1997) 1140-1142
13. al-Za'abi M., Deleu D., and Batchelor C. Salivary free concentrations of anti-epileptic drugs: an evaluation in a routine clinical setting. Acta Neurologica Belgica 103 (2003) 19-23
14. Herkes G.K., and Eadie M.J. Daily salivary anticonvulsant monitoring in patients with intractable epilepsy. Clin Exp Neurol 26 (1989) 141-149
15. Herkes G.K., and Eadie M.J. Possible roles for frequent salivary antiepileptic drug monitoring in the management of epilepsy. Epilepsy Research 6 (1990) 146-154
16. Cohen A.F., Land G.S., Breimer D.D., et al. Lamotrigine, a new anticonvulsant: pharmacokinetics in normal humans. Clin Pharmacol Ther 42 (1987) 535-541
17. Dickinson R.G., Hooper W.D., King A.R., et al. Fallacious results from measuring salivary carbamazepine concentrations. Ther Drug Monit 7 (1985) 41-45