Thimet oligopeptidase (EC 3.4.24.15) activates CPI-0004Na, an extracellularly tumour-activated prodrug of doxorubicin

European Journal of Cancer

Volumn 42, Issue 17, 2006, Pages 3049-3056

  Dubois, V ^a   Nieder, M ^b   Collot, F ^a   Negrouk, A ^a   Nguyen, T T ^b   Gangwar, S ^b   Reitz, B ^b   Wattiez, R ^c   Dasnois, L ^a   Trouet, A ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^b GLAXOSMITHKLINE   (United States)

^c UNIVERSITY OF MONS   (Belgium)

Author keywords

Adriamycin; Cancer; Chemotherapy; Doxorubicin; Drug targeting; Prodrug

Indexed keywords

CPI 0004NA; DOXORUBICIN; DOXORUBICIN DERIVATIVE; N ALANYLLEUCINE DOXORUBICIN; N LEUCINE DOXORUBICIN; PRODRUG; THIMET OLIGOPEPTIDASE; THIOL; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CONTROLLED STUDY; DRUG ACTIVATION; DRUG HYDROLYSIS; ELECTROSPRAY; HELA CELL; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; PH; PRIORITY JOURNAL; TIME OF FLIGHT MASS SPECTROMETRY;

EID: 33750517063     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejca.2005.10.030     Document Type: Article

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