Age-dependent bimodal GDNF regulation during ovarian tumorigenesis in follitropin receptor mutant mice

Biochemical and Biophysical Research Communications

Volumn 351, Issue 2, 2006, Pages 507-513

  Aravindakshan, J ^a   Chen, X L ^a   Sairam, M R ^a  

^a CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

Author keywords

Aging; Androgen; Follitropin receptor; GDNF; Gene expression; Immunolocalization; Knockout; Microarray; Ovary; Tumors

Indexed keywords

ANDROGEN; FOLLITROPIN RECEPTOR; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; NEUROTROPIC AGENT;

AGING; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CONTROLLED STUDY; DOWN REGULATION; GRANULOSA CELL; HORMONE ACTION; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; OOCYTE; OVARY; OVARY TUMOR; PATHOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; STROMA CELL; UPREGULATION;

AGING; ANIMALS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; MICE; MICE, KNOCKOUT; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OOCYTES; OVARIAN NEOPLASMS; PRECANCEROUS CONDITIONS; RECEPTORS, FSH; STROMAL CELLS;

EID: 33750516523     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2006.10.069     Document Type: Article

References (21)

1. Dierich A., Sairam M.R., Monaco L., Fimia G.M., Gansmuller A., LeMeur M., and Sassone-Corsi P. Impairing follicle-stimulating hormone (FSH) signaling in vivo: Targeted disruption of the FSH receptor leads to aberrant gametogenesis and hormonal imbalance. Proc. Natl. Acad. Sci. USA 95 (1998) 13612-13617
2. Danilovich N., Babu P.S., Xing W.R., Gerdes M., Krishnamurthy H., and Sairam M.R. Estrogen deficiency, obesity, and skeletal abnormalities in follicle-stimulating hormone receptor knockout (FORKO) female mice. Endocrinology 141 (2000) 4295-4308
3. Danilovich N., Roy I., and Sairam M.R. Ovarian pathology and high incidence of sex cord tumors in follitropin receptor knockout (FORKO) mice. Endocrinology 142 (2001) 3673-3684
4. Keri R.A., Lozada K.L., Abdul-Karim F.W., Nadeau J.H., and Nilson J.H. Luteinizing hormone induction of ovarian tumors: Oligogenic differences between mouse strains dictates tumor disposition. Proc. Natl. Acad. Sci. USA 97 (2000) 383-387
5. Matzuk M.M., Finegold M.J., Su J.G.J., Hsueh A.J.W., and Bradley A. Alpha-inhibin is a tumor-suppressor gene with gonadal specificity in mice. Nature 360 (1992) 313-319
6. Sariola H., and Saarma M. Novel functions and signalling pathways for GDNF. J. Cell. Sci. 116 (2003) 3855-3862
7. Pichel J.G., Shen L.Y., Sheng H.Z., Granholm A.C., Drago J., Grinberg A., Lee E.J., Huang S.P., Saarma M., Hoffer B.J., Sariola H., and Westphal H. Defects in enteric innervation and kidney development in mice lacking GDNF. Nature 382 (1996) 73-76
8. Meng X.J., Lindahl M., Hyvonen M.E., Parvinen M., de Rooij D.G., Hess M.W., Raatikainen-Ahokas A., Sainio K., Rauvala H., Lakso M., Pichel J.G., Westphal H., Saarma M., and Sariola H. Regulation of cell fate decision of undifferentiated spermatogonia by GDNF. Science 287 (2000) 1489-1493
9. Trupp M., Ryden M., Jornvall H., Funakoshi H., Timmusk T., Arenas E., and Ibanez C.F. Peripheral expression and biological-activities of Gdnf, a new neurotrophic factor for avian and mammalian peripheral neurons. J. Cell. Biol. 130 (1995) 137-148
10. Golden J.P., Demaro J.A., Osborne P.A., Milbrandt J., and Johnson E.M. Expression of neurturin, GDNF, and GDNF family-receptor mRNA in the developing and mature mouse. Exp. Neurol. 158 (1999) 504-528
11. Widenfalk J., Parvinen M., Lindqvist E., and Olson L. Neurturin, RET, GFR alpha-1 and GFR alpha-2, but not GFR alpha-3, mRNA are expressed in mice gonads. Cell Tissue Res. 299 (2000) 409-415
12. Meng X.J., de Rooij D.G., Westerdahl K., Saarma M., and Sariola H. Promotion of seminomatous tumors by targeted overexpression of glial cell line-derived neurotrophic factor in mouse testis. Cancer Res. 61 (2001) 3267-3271
13. Carmina E. The spectrum of androgen excess disorders. Fertil. Steril. 85 (2006) 1582-1585
14. Balla A., Danilovich N., Yang Y.Z., and Sairam M.R. Dynamics of ovarian development in the FORKO immature mouse: Structural and functional implications for ovarian reserve. Biol. Reprod. 69 (2003) 1281-1293
15. R. Tiwari-Pandey, Y.Z. Yang, J. Aravindakshan, M.R. Sairam, Ovarian transplantation in follitropin receptor knockout (FORKO) mice: potential reversal of endocrine abnormalities, Biol. Reprod. Special Issue (2005) Abstract 124, p109.
16. Tadokoro Y., Yomogida K., Ohta H., Tohda A., and Nishimune Y. Homeostatic regulation of germinal stem cell proliferation by the GDNF/FSH pathway. Mech. Dev. 113 (2002) 29-39
17. Eppig J.J., Wigglesworth K., and Pendola F.L. The mammalian oocyte orchestrates the rate of ovarian follicular development. Proc. Natl. Acad. Sci. USA 99 (2002) 2890-2894
18. Lin L.F.H., Doherty D.H., Lile J.D., Bektesh S., and Collins F. Gdnf-a glial-cell line derived neurotrophic factor for midbrain dopaminergic-neurons. Science 260 (1993) 1130-1132
19. Moore M.W., Klein R.D., Farinas I., Sauer H., Armanini M., Phillips H., Reichardt L.F., Ryan A.M., CarverMoore K., and Rosenthal A. Renal and neuronal abnormalities in mice lacking GDNF. Nature 382 (1996) 76-79
20. Paratcha G., Ledda F., and Ibanez C.F. The neural cell adhesion molecule NCAM is an alternative signaling receptor for GDNF family Ligands. Cell 113 (2003) 867-879
21. Chao C.C., Ma Y.L., Chu K.Y., and Lee E.H.Y. Integrin alpha v and NCAM mediate the effects of GDNF on DA neuron survival, outgrowth, DA turnover and motor activity in rats. Neurobiol. Aging 24 (2003) 105-116