Evaluation of the acquired immune responses to Plasmodium vivax VIR variant antigens in individuals living in malaria-endemic areas of Brazil

Malaria Journal

Volumn 5, Issue , 2006, Pages

  Oliveira, Tatiane R ^a   Fernandez Becerra, Carmen ^a   Jimenez, Maria Carolina S ^a   Del Portillo, Hernando A ^a   Soares, Irene S ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTATHIONE TRANSFERASE; HYBRID PROTEIN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; PROTEIN VIR A; PROTEIN VIR B; PROTEIN VIR C; PROTEIN VIR E; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; VIRUS ANTIGEN;

ARTICLE; BRAZIL; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; IMMUNE RESPONSE; IN VITRO STUDY; MAJOR CLINICAL STUDY; MALARIA; PLASMODIUM VIVAX; PREVALENCE; PROTEIN PURIFICATION;

ADOLESCENT; ADULT; ANIMALS; ANTIBODIES, BACTERIAL; ANTIGENS, PROTOZOAN; BRAZIL; FEMALE; GENETIC VARIATION; HUMANS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; MALARIA, VIVAX; MALE; MIDDLE AGED; PLASMODIUM VIVAX;

EID: 33750514321     PISSN: 14752875     EISSN: 14752875     Source Type: Journal    
DOI: 10.1186/1475-2875-5-83     Document Type: Article

References (39)

1. Mendis K, Sina BJ, Marchesini P, Carter R: The neglected burden of Plasmodium vivax malaria. Am J Trop Med Hyg 2001, 64:97-106.
2. Secretaria de Vigilância em Saúde-SVS, Ministério da Saúde [http://www.saude.gov.br]
3. Del Portillo HA, Fernandez-Becerra C, Bowman S, Oliver K, Preuss M, Sanchez CP, Schneider NK, Villalobos JM, Rajandream MA, Harris D, Pereira da Silva LH, Barrel B, Lanzer M: A superfamily of variant genes encoded in the subtelomeric region of Plasmodium vivax. Nature 2001, 410:839-842.
4. Fernandez-Becerra C, Pein O, Oliveira TR, Yamamoto MM, Cassola AC, Rocha C, Soares IS, de Bragança-Pereira CA, Del Portillo HA: Variant proteins of Plasmodium vivax are not clonally expressed in natural infections. Mol Microbiol 2005, 58:648-658.
5. Merino EF, Fernandez-Becerra C, Durham AM, Ferreira JE, Tumilasci VF, d'Arc-Neves J, da Silva-Nunes M, Ferreira MU, Wickramarachchi T, Udagama-Randeniya P, Handunnetti SM, del Portillo HA: Multicharacter population study of the vir subtelomeric multigene superfamily of Plasmodium vivax, a major human malaria parasite. Mol Biochem Parasitol 2006 in press.
6. Janssen CS, Phillips RS, Turner CM, Barrett MP: Plasmodium interspersed repeats: the major multigene superfamily of malaria parasites. Nucleic Acids Res 2004, 32:5712-5720.
7. Kaviratne M, Fernandez V, Jarra W, Cunningham D, Galinski MR, Wahlgren M, Preiser PR: Antigenic Variation in Plasmodium falciparum and other Plasmodium species. In Antigenic Variation Volume 14. Edited by: Craig A, Scherf A. Oxford, Elsevier; 2003:291-318.
8. Del Portillo HA, Lanzer M, Rodríguez-Malaga S, Zavala F, Fernandez-Becerra C: Variant genes and the spleen in Plasmodium vivax malaria. Int J Parasitol 2004, 34:1547-1554.
9. Marsh K, Otoo L, Hayes RJ, Carson DC, Greenwood BM: Antibodies to blood stage antigens of Plasmodium falciparum in rural Gambians and their relation to protection against infection. Trans R Soc Trop Med Hyg 1989, 83:293-303.
10. Bull PC, Lowe BS, Kortok M, Molyneux CS, Newbold CI, Marsh K: Parasite antigens on the infected red cell surface are targets for naturally acquired immunity to malaria. Nat Med 1998, 4:358-360.
11. Dodoo D, Staalsoe T, Giha H, Kurtzhals JA, Akanmori BD, Koram K, Dunyo S, Nkrumah FK, Hyiid L, Theander TG: Antibodies to variant antigens on the surfaces of infected erythrocytes are associated with protection from malaria in Ghanaian children. Infect Immun 2001, 69:3713-3718.
12. Tebo AE, Kremsner PG, Piper KP, Luty AJ: Low antibody responses to variant surface antigens of Plasmodium falciparum are associated with severe malaria and increased susceptibility to malaria attacks in Gabonese children. Am J Trop Med Hyg 2002, 67:597-603.
13. Abdel-Latif MS, Dietz K, Issifou S, Kremsner PG, Klinkert MQ: Antibodies to Plasmodium falciparum Rifin proteins are associated with rapid parasite clearance and asymptomatic infections. Infect Immun 2003, 71:6229-6233.
14. Smith JD, Chitnis CE, Craig AG, Roberts DJ, Hudson-Taylor DE, Peterson DS, Pinches R, Newbold CI, Miller LH: Switches in expression of Plasmodium falciparum var genes correlate with changes in antigenic and cytoadherent phenotypes of infected erythrocytes. Cell 1995, 82:101-110.
15. Fernandez V, Hommel M, Chen Q, Hagblom P, Wahlgren M: Small, clonally variant antigens expressed on the surface of the Plasmodium falciparum -infected erythrocyte are encoded by the rif gene family and are the target of human immune responses. J Exp Med 1999, 190:1393-1404.
16. Kyes SA, Rowe JA, Kriek N, Newbold CI: Rifins: A second family of clonally variant proteins expressed on the surface of red cells infected with Plasmodium falciparum. Proc Natl Acad Sci USA 1999, 96:9333-9338.
17. Soares IS, Cunha MG, Silva MN, Souza JM, Del Portillo HA, Rodrigues MM: Longevity of naturally acquired antibody responses to the N and C-terminal regions of Plasmodium vivax merozoite surface protein 1. Am J Trop Med Hyg 1999, 60:357-363.
18. Rodrigues MHC, Cunha MG, Machado RLD, Ferreira-Jr OC, Rodrigues MM, Soares IS: Serological detection of Plasmodium vivax malaria using recombinant proteins corresponding to the 19-kDa C-terminal region of the merozoite surface protein-1. Malar J 2003, 2:39.
19. Rodrigues MHC, Rodrigues KM, Oliveira TR, Comodo AN, Rodrigues MM, Kocken CH, Thomas AW, Soares IS: Antibody response of naturally infected individuals to recombinant Plasmodium vivax apical membrane antigen-1. Int J Parasitol 2005, 35:185-192.
20. 19 expressed in distinct bacterial vectors. Vaccine 2001, 20:385-396.
21. Soares IS, Levitus G, Souza JM, Del Portillo HA, Rodrigues MM: Acquired immune responses to the N- and C-terminal regions of Plasmodium vivax merozoite surface protein 1 in individuals exposed to malaria. Infect Immun 1997, 65:1606-1614.
22. Soares IS, Barnwell JW, Ferreira MU, Cunha MG, Laurino JP, Castilho BA, Rodrigues MM: A Plasmodium vivax vaccine candidate displays limited allele polymorphism, which does not restrict recognition by antibodies. Mol Med 1999, 5:459-470.
23. Marsh K, Howard RJ: Antigens induced on erythrocytes by P. falciparum : expression of diverse and conserved determinants. Science 1986, 231:150-153.
24. Forsyth KP, Philip G, Smith T, Kum E, Southwell B, Brown GV: Diversity of antigens expressed on the surface of erythrocytes infected with mature Plasmodium falciparum parasites in Papua New Guinea. Am J Trop Med Hyg 1989, 41:259-265.
25. Newbold CI, Pinches R, Roberts DJ, Marsh K: Plasmodium falciparum : the human agglutinating antibody response to the infected red cell surface is predominantly variant specific. Exp Parasitol 1992, 75:281-292.
26. Iqbal J, Perlmann P, Berzins K: Serological diversity of antigens expressed on the surface of erythrocytes infected with Plasmodium falciparum. Trans R Soc Trop Med Hyg 1993, 87:583-588.
27. Bull PC, Lowe BS, Kortok M, Marsh K: Antibody recognition of Plasmodium falciparum erythrocyte surface antigens in Kenya: evidence for rare and prevalent variants. Infect Immun 1999, 67:733-739.
28. Giha HA, Staalsoe T, Dodoo D, Elhassan IM, Roper C, Satti GMH, Arnot DE, Theander TG, Hviid L: Nine-Year longitudional study of antibodies to variant antigens on the surface of Plasmodium falciparum -infected erythrocytes. Infect Immun 1999, 67:4092-4098.
29. van Schravendijk MR, Rock EP, Marsh K, Ito Y, Aikawa M, Neequaye J, Ofori Adjei D, Rodriguez R, Patarroyo ME, Howard RJ: Characterization and localization of Plasmodium falciparum surface antigens on infected erythrocytes from west African patients. Blood 1991, 78:226-236.
30. Chattopadhyay R, Sharma A, Srivastava VK, Pati SS, Sharma SK, Das BS, Chitnis CE: Plasmodium falciparum infection elicits both variant-specific and cross-reactive antibodies against variant surface antigens. Infect Immun 2003, 71:597-604.
31. Oguariri RM, Borrmann S, Klinkert MQ, Kremsner PG, Kun JF: High prevalence of human antibodies to recombinant Duffy binding-like alpha domains of the Plasmodium falciparum -infected erythrocyte membrane protein 1 in semi-immune adults compared to that in nonimmune children. Infect Immun 2001, 69:7603-7609.
32. Abdel-Latif MS, Khattab A, Lindenthal C, Kremsner PG, Klinkert MQ: Recognition of variant Rifin antigens by human antibodies induced during natural Plasmodium falciparum infections. Infect Immun 2002, 70:7013-7021.
33. Abdel-Latif MS, Cabrera G, Kohler C, Kremsner PG, Luty AJ, 1-95/C. Study Team: Antibodies to rifin: a component of naturally acquired responses to Plasmodium falciparum variant surface antigens on infected erythrocytes. Am J Trop Med Hyg 2004, 71:179-186.
34. Piper KP, Roberts DJ, Day KP: Plasmodium falciparum : analysis of the antibody specificity to the surface of the trophozoite-infected erythrocyte. Exp Parasitol 1999, 91:161-169.
35. Megnekou R, Staalsoe T, Taylor DW, Leke R, Hviid L: Effects of pregnancy and intensity of Plasmodium falciparum transmission on immunoglobulin G subclass responses to variant surface antigens. Infect Immun 2005, 73:4112-4118.
36. Kinyanjui SM, Bull P, Newbold CI, Marsh K: Kinetics of antibody responses to Plasmodium falciparum -infected erythrocyte variant surface antigens. J Infect Dis 2003, 187:667-674.
37. Cabrera G, Yone C, Tebo AE, Van Aaken J, Lell B, Kremsner PG, Luty AJ: Immunoglobulin G isotype responses to variant surface antigens of Plasmodium falciparum in healthy Gabonese adults and children during and after successive malaria attacks. Infect Immun 2004, 72:284-294.
38. Allsopp CE, Sanni LA, Reubsaet L, Ndungu F, Newbold C, Mwangi T, Marsh K, Langhorne J: CD4 T cell responses to a variant antigen of the malaria parasite Plasmodium falciparum, erythrocyte membrane protein-1, in individuals living in malaria-endemic areas. J Infect Dis 2002, 185:812-819.
39. Sanni LA, Allsopp CE, Reubsaet L, Sanni A, Newbold C, Chauhan VS, Langhorne J: Cellular responses to Plasmodium falciparum erythrocyte membrane protein-1: use of relatively conserved synthetic peptide pools to determine CD4 T cell responses in malaria-exposed individuals in Benin, West Africa. Malar J 2002, 1:7.