Application of aldehyde dehydrogenase 2 (ALDH2) genetic diagnosis in support of decreasing alcohol intake

Journal of Occupational Health

Volumn 48, Issue 3, 2006, Pages 161-165

  Komiya, Yasuhiro ^a   Nakao, Hiroyuki ^a   Kuroda, Yoshiki ^a   Arizono, Katsuyuki ^a   Nakahara, Ai ^a   Katoh, Takahiko ^a  

^a UNIVERSITY OF MIYAZAKI   (Japan)

Author keywords

Alcohol intake; Aldehyde dehydrogenase 2; Genetic diagnosis; Health support; Polymorphism

Indexed keywords

ALDEHYDE DEHYDROGENASE ISOENZYME 2;

ALCOHOL CONSUMPTION; ARTICLE; BEHAVIOR CHANGE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRINKING BEHAVIOR; GENETIC ANALYSIS; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; LIFESTYLE; LIVER FUNCTION TEST; MALE; RANDOMIZED CONTROLLED TRIAL;

ALCOHOL DRINKING; ALDEHYDE DEHYDROGENASE; BEHAVIOR CONTROL; GENETIC SCREENING; GENOTYPE; HEALTH BEHAVIOR; HEALTH KNOWLEDGE, ATTITUDES, PRACTICE; HUMANS; JAPAN; LIVER; MALE; POLYMORPHISM, GENETIC; RISK-TAKING; STATISTICS, NONPARAMETRIC; TREATMENT OUTCOME;

EID: 33750509429     PISSN: 13419145     EISSN: 13419145     Source Type: Journal    
DOI: 10.1539/joh.48.161     Document Type: Article

References (11)

1. S Harada, DP Agarwal and HW Goedde: Aldehyde dehydrogenase deficiency as cause of facial flushing reaction to alcohol in Japanese. Lancet 2, 982 (1981)
2. A Yokoyama, T Muramatsu, T Ohmori, S Higuchi, M Hayashida and H Ishii: Esophageal cancer and aldehyde dehydrogenase-2 genotypes in Japanese males. Cancer Epidemiol Biomarkers Prev 5, 99-102 (1996)
3. A Yokoyama, H Kato, T Yokoyama, T Tsujinaka, M Muto, T Omori, T Haneda, Y Kumagai, H Igaki, M Yokoyama, H Watanabe, H Fukuda and H Yoshimizu: Genetic polymorphism of alcohol and aldehyde dehydrogenases and glutathione S-transferase M1 and drinking, smoking, and diet in Japanese men with esophageal squamous cell carcinoma. Carcinogenesis 23, 1851-1859 (2002)
4. Y Komiya, H Nakao, Y Kuroda, K Arizono, A Nakahara and T Katoh: Consciousness survey regarding genetic diagnosis of glutathione S-transferase M1 (GSTM1) and aldehyde dehydrogenase 2 (ALDH2) polymorphism. San Ei Shi 47, 204-209 (2005)
5. S Harada and S Zhang: New strategy for detection of ALDH2 mutant. Alcohol Alcoholism Suppl 1A, 11-13 (1993)
6. K Reynolds, B Lewis, JD Nolen, GL Kinney, B Sathya and J He: Alcohol consumption and risk of stroke:a meta-analysis. JAMA 289, 579-588 (2003)
7. The WCRF/AICR Expert Report. Food, Nutrition and the prevention of cancer: a global perspective, provides the vital scientific evidence for all of AICR research and education programs. Washington, DC: BANTA Book Group, 1997.
8. T Takeshita, K Morimoto, XQ Mao, T Hashimoto and J Furuyama: Phenotypic differences in low Km aldehyde dehydrogenase in Japanese workers. Lancet 8848, 837-838 (1993)
9. HW Goedde, DP Agarwal, G Fritze, D Meier-Tackmann, S Singh, G Beckmann, K Bhatia, LZ Chen, B Fang and R Lisker: Distribution of ADH2 and ALDH2 genotypes in different populations. Hum Genet 88, 344-346 (1992)
10. S Higuchi: Polymorphisms of ethanol metabolizing enzyme genes and alcoholism. Alcohol Alcohol Suppl 2, 29-34 (1994)
11. T Takeshita, XQ Mao and K Morimoto: The contribution of polymorphism in the alcohol dehydrogenase beta subunit to alcohol sensitivity in a Japanese population. Hum Genet 97, 409-413 (1996)