The Effects of Tamsulosin and Sildenafil in Separate and Combined Regimens on Detailed Hemodynamics in Patients With Benign Prostatic Enlargement

Journal of Urology

Volumn 176, Issue 6, 2006, Pages 2551-2556

  Nieminen, Tuomo ^a   Tammela, Teuvo L J ^a,b   Kööbi, Tiit ^a,b   Kähönen, Mika ^a,b  

^a TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^b TAMPERE UNIVERSITY HOSPITAL   (Finland)

Author keywords

adrenergic alpha antagonists; adrenergic antagonists; phosphodiesterase inhibitors; supine position; tilt table test

Indexed keywords

PLACEBO; SILDENAFIL; TAMSULOSIN;

ADULT; AGED; ARTICLE; BENIGN TUMOR; BLOOD PRESSURE MEASUREMENT; CLINICAL ARTICLE; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIASTOLIC BLOOD PRESSURE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FINGER; HEAD TILTING; HEART RATE; HEMODYNAMICS; HUMAN; IMPEDANCE CARDIOGRAPHY; MALE; PRIORITY JOURNAL; PROSTATE HYPERTROPHY; PULSE WAVE; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; SINGLE DRUG DOSE; STANDING; STATISTICAL SIGNIFICANCE; SUPINE POSITION; SYSTEMIC VASCULAR RESISTANCE; SYSTOLIC BLOOD PRESSURE; TREATMENT OUTCOME;

3',5'-CYCLIC-GMP PHOSPHODIESTERASE; ADRENERGIC ALPHA-ANTAGONISTS; AGED; ALGORITHMS; BLOOD PRESSURE; CARDIOGRAPHY, IMPEDANCE; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; HEART RATE; HUMANS; MALE; MIDDLE AGED; PIPERAZINES; PROSTATIC HYPERPLASIA; SULFONAMIDES; TILT-TABLE TEST; VASCULAR RESISTANCE;

EID: 33750505401     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.juro.2006.07.154     Document Type: Article

References (20)

1. 1-Adrenergic receptors and their inhibitors in lower urinary tract symptoms and benign prostatic hyperplasia. J Urol 171 (2004) 1029
2. Haning H., Niewohner U., and Bischoff E. Phosphodiesterase type 5 (PDE5) inhibitors. Prog Med Chem 41 (2003) 249
3. Michel M.C., Flannery M.T., and Narayan P. Worldwide experience with alfuzosin and tamsulosin. Urology 58 (2001) 508
4. Wilt T.J., MacDonald R., and Nelson D. Tamsulosin for treating lower urinary tract symptoms compatible with benign prostatic obstruction: a systematic review of efficacy and adverse effects. J Urol 167 (2002) 177
5. de Mey C. Cardiovascular effects of alpha-blockers used for the treatment of symptomatic BPH: impact on safety and well-being. Eur Urol 34 (1998) 18
6. Kloner R.A., Jackson G., Emmick J.T., Mitchell M.I., Bedding A., Warner M.R., et al. Interaction between the phosphodiesterase 5 inhibitor, tadalafil and 2 α-blockers, doxazosin and tamsulosin in healthy normotensive men. J Urol 172 (2004) 1935
7. Lee M. Tamsulosin for the treatment of benign prostatic hypertrophy. Ann Pharmacother 34 (2000) 188
8. Nieminen T., Ylitalo R., Kööbi T., Ylitalo P., and Kähönen M. The vasodilatory effect of alfuzosin and tamsulosin in passive orthostasis: a randomised, double-blind, placebo-controlled study. Eur Urol 47 (2005) 340
9. Guimaraes S., and Moura D. Vascular adrenoceptors: an update. Pharmacol Rev 53 (2001) 319
10. Kloner R.A. Novel phosphodiesterase type 5 inhibitors: assessing hemodynamic effects and safety parameters. Clin Cardiol 27 (2004) I20
11. Pomara G., Morelli G., Pomara S., Taddei S., Ghiadoni L., Dinelli N., et al. Cardiovascular parameter changes in patients with erectile dysfunction using pde-5 inhibitors: a study with sildenafil and vardenafil. J Androl 25 (2004) 625
12. Zusman R.M., Morales A., Glasser D.B., and Osterloh I.H. Overall cardiovascular profile of sildenafil citrate. Am J Cardiol 83 (1999) 35C
13. Auerbach S.M., Gittelman M., Mazzu A., Cihon F., Sundaresan P., and White W.B. Simultaneous administration of vardenafil and tamsulosin does not induce clinically significant hypotension in patients with benign prostatic hyperplasia. Urology 64 (2004) 998
14. Matsushima H., Kamimura H., Soeishi Y., Watanabe T., Higuchi S., and Tsunoo M. Pharmacokinetics and plasma protein binding of tamsulosin hydrochloride in rats, dogs, and humans. Drug Metab Dispos 26 (1998) 240
15. Nichols D.J., Muirhead G.J., and Harness J.A. Pharmacokinetics of sildenafil after single oral doses in healthy male subjects: absolute bioavailability, food effects and dose proportionality. Br J Clin Pharmacol 53 (2002) 5S
16. Kööbi T., Kaukinen S., Ahola T., and Turjanmaa V.M. Non-invasive measurement of cardiac output: whole-body impedance cardiography in simultaneous comparison with thermodilution and direct oxygen Fick methods. Intensive Care Med 23 (1997) 1132
17. Imholz B.P., van Montfrans G.A., Settels J.J., van der Hoeven G.M., Karemaker J.M., and Wieling W. Continuous non-invasive blood pressure monitoring: reliability of Finapres device during the Valsalva manoeuvre. Cardiovasc Res 22 (1988) 390
18. Kööbi T., Kähönen M., Iivainen T., and Turjanmaa V. Simultaneous non-invasive assessment of arterial stiffness and haemodynamics - a validation study. Clin Physiol Funct Imaging 23 (2003) 31
19. Jackson G., Benjamin N., Jackson N., and Allen M.J. Effects of sildenafil citrate on human hemodynamics. Am J Cardiol 83 (1999) 13C
20. Mukai S., and Lipsitz L.A. Orthostatic hypotension. Clin Geriatr Med 18 (2002) 253