Interleukin-2 inhibits NMDA receptor-mediated currents directly and may differentially affect subtypes

Biochemical and Biophysical Research Communications

Volumn 351, Issue 2, 2006, Pages 449-454

  Shen, Yi ^a   Zhu, Li Jun ^a   Liu, Shuang Shuang ^a   Zhou, Su Ya ^a   Luo, Jian Hong ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Hippocampal neuron; Interleukin 2; NMDA receptors; Rat; Whole cell patch clamp

Indexed keywords

INTERLEUKIN 2; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; RECOMBINANT RECEPTOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; HIPPOCAMPUS; HUMAN; HUMAN CELL; NERVE CELL CULTURE; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT; STATISTICAL SIGNIFICANCE; WHOLE CELL;

ANIMALS; CELLS, CULTURED; CLONING, MOLECULAR; HIPPOCAMPUS; HUMANS; INTERLEUKIN-2; ION CHANNEL GATING; NEURONS; PATCH-CLAMP TECHNIQUES; PROTEIN ISOFORMS; RATS; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 33750494539     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2006.10.047     Document Type: Article

References (27)

1. Hanisch U.K., and Quirion R. Interleukin-2 as a neuroregulatory cytokine. Brain Res. Brain Res. Rev. 21 (1995) 246-284
2. Jiang C.L., and Lu C.L. Interleukin-2 and its effects in the central nervous system. Biol. Signals Recept. 7 (1998) 148-156
3. Lapchak P.A., Araujo D.M., Quirion R., and Beaudet A. Immunoautoradiographic localization of interleukin 2-like immunoreactivity and interleukin 2 receptors (Tac antigen-like immunoreactivity) in the rat brain. Neuroscience 44 (1991) 173-184
4. Luber-Narod J., and Rogers J. Immune system associated antigens expressed by cells of the human central nervous system. Neurosci. Lett. 94 (1988) 17-22
5. Eizenberg O., Faber-Elman A., Lotan M., and Schwartz M. Interleukin-2 transcripts in human and rodent brains: possible expression by astrocytes. J. Neurochem. 64 (1995) 1928-1936
6. Kowalski J., Labuzek K., and Herman Z.S. Flupentixol and trifluperidol reduce interleukin-1 beta and interleukin-2 release by rat mixed glial and microglial cell cultures. Pol. J. Pharmacol. 56 (2004) 563-570
7. Sarder M., Abe K., Saito H., and Nishiyama N. Comparative effect of IL-2 and IL-6 on morphology of cultured hippocampal neurons from fetal rat brain. Brain Res. 715 (1996) 9-16
8. Sarder M., Saito H., and Abe K. Interleukin-2 promotes survival and neurite extension of cultured neurons from fetal rat brain. Brain Res. 625 (1993) 347-350
9. Lacosta S., Merali Z., and Anisman H. Influence of acute and repeated interleukin-2 administration on spatial learning, locomotor activity, exploratory behaviors, and anxiety. Behav. Neurosci. 113 (1999) 1030-1041
10. Petitto J.M., McNamara R.K., Gendreau P.L., Huang Z., and Jackson A.J. Impaired learning and memory and altered hippocampal neurodevelopment resulting from interleukin-2 gene deletion. J. Neurosci. Res. 56 (1999) 441-446
11. Robinson M.A., Veliz Y., Bergado J., Serrano T., Rosillo J.C., Ivett C., Arana M., Quijano Z., Castellano O., and Telleria A. Neuronal toxicity of human recombinant interleukin-2 in rats. Morphological and behavioral validation. Rev. Neurol. 25 (1997) 452-456
12. Tancredi V., Zona C., Velotti F., Eusebi F., and Santoni A. Interleukin-2 suppresses established long-term potentiation and inhibits its induction in the rat hippocampus. Brain Res. 525 (1990) 149-151
13. Luo J.H., Fu Z.Y., Losi G., Kim B.G., Prybylowski K., Vissel B., and Vicini S. Functional expression of distinct NMDA channel subunits tagged with green fluorescent protein in hippocampal neurons in culture. Neuropharmacology 42 (2002) 306-318
14. Ye J.H., Tao L., and Zalcman S.S. Interleukin-2 modulates N-methyl-d-aspartate receptors of native mesolimbic neurons. Brain Res. 894 (2001) 241-248
15. Qiu S., Hua Y.L., Yang F., Chen Y.Z., and Luo J.H. Subunit assembly of N-methyl-d-aspartate receptors analyzed by fluorescence resonance energy transfer. J. Biol. Chem. 280 (2005) 24923-24930
16. Suminami Y., Kashii Y., Law J.C., Lin W.C., Stanson J., Reichert T.E., Rabinowich H., and Whiteside T.L. Molecular analysis of the IL-2 receptor beta chain gene expressed in human tumor cells. Oncogene 16 (1998) 1309-1317
17. Xu S., Ning W., Xu Z., Zhou S., Chiang H., and Luo J. Chronic exposure to GSM 1800-MHz microwaves reduces excitatory synaptic activity in cultured hippocampal neurons. Neurosci. Lett. 398 (2006) 253-257
18. Huberman M., Shalit F., Roth-Deri I., Gutman B., Brodie C., Kott E., and Sredni B. Correlation of cytokine secretion by mononuclear cells of Alzheimer patients and their disease stage. J. Neuroimmunol. 52 (1994) 147-152
19. Araujo D.M., and Lapchak P.A. Induction of immune system mediators in the hippocampal formation in Alzheimer's and Parkinson's diseases: selective effects on specific interleukins and interleukin receptors. Neuroscience 61 (1994) 745-754
20. Singh V.K. Studies of neuroimmune markers in Alzheimer's disease. Mol. Neurobiol. 9 (1994) 73-81
21. Bliss T.V., and Collingridge G.L. A synaptic model of memory: long-term potentiation in the hippocampus. Nature 361 (1993) 31-39
22. Morris R.G., Anderson E., Lynch G.S., and Baudry M. Selective impairment of learning and blockade of long-term potentiation by an N-methyl-d-aspartate receptor antagonist, AP5. Nature 319 (1986) 774-776
23. Lai A.Y., Swayze R.D., El-Husseini A., and Song C. Interleukin-1 beta modulates AMPA receptor expression and phosphorylation in hippocampal neurons. J. Neuroimmunol. 175 (2006) 97-106
24. Wang Y., Pei G., Cai Y.C., Zhao Z.Q., Wang J.B., Jiang C.L., Zheng Z.C., and Liu X.Y. Human interleukin-2 could bind to opioid receptor and induce corresponding signal transduction. Neuroreport 8 (1996) 11-14
25. Dingledine R., Borges K., Bowie D., and Traynelis S.F. The glutamate receptor ion channels. Pharmacol. Rev. 51 (1999) 7-61
26. Cull-Candy S., Brickley S., and Farrant M. NMDA receptor subunits: diversity, development and disease. Curr. Opin. Neurobiol. 11 (2001) 327-335
27. Liu L., Wong T.P., Pozza M.F., Lingenhoehl K., Wang Y., Sheng M., Auberson Y.P., and Wang Y.T. Role of NMDA receptor subtypes in governing the direction of hippocampal synaptic plasticity. Science 304 (2004) 1021-1024