Late response to radiochemotherapy in pediatric glioblastoma: Report on two patients treated according to HIT-GBM protocols

Pediatric Hematology and Oncology

Volumn 23, Issue 8, 2006, Pages 631-637

  Classen, Carl Friedrich ^a,b   Warmuth Metz, M ^c   Papke, K ^a   Trotter, A ^a,d   Wolff, J E A ^e,f   Wagner, S ^f  

^a Klinikum Duisburg   (Germany)

^b ROSTOCK UNIVERSITY MEDICAL CENTER   (Germany)

^c UNIVERSITY OF WÜRZBURG   (Germany)

^d Hegau Klinikum GmbH   (Germany)

^e UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^f UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

Glioblastoma; Pediatric; Radiochemotherapy; Response control

Indexed keywords

CISPLATIN; ETOPOSIDE; IFOSFAMIDE; LOMUSTINE; PREDNISOLONE; PREDNISONE; STEROID; VINCRISTINE;

ARTICLE; CANCER CHEMOTHERAPY; CANCER DIAGNOSIS; CANCER GRADING; CANCER GROWTH; CANCER RADIOTHERAPY; CANCER SURGERY; CASE REPORT; CLINICAL FEATURE; GLIOBLASTOMA; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LABORATORY TEST; LEUKOPENIA; MALE; SCHOOL CHILD; TREATMENT DURATION; TREATMENT RESPONSE;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BRAIN STEM NEOPLASMS; CHILD; CISPLATIN; COMBINED MODALITY THERAPY; CRANIAL IRRADIATION; CRANIOTOMY; DISEASE PROGRESSION; ETOPOSIDE; FATAL OUTCOME; FOLLOW-UP STUDIES; GLIOBLASTOMA; HUMANS; IFOSFAMIDE; MALE; RANDOMIZED CONTROLLED TRIALS; REMISSION INDUCTION; SUPRATENTORIAL NEOPLASMS; TIME FACTORS; TREATMENT OUTCOME; VINCRISTINE;

EID: 33750491968     PISSN: 08880018     EISSN: 15210669     Source Type: Journal    
DOI: 10.1080/08880010600951088     Document Type: Article

References (7)

1. Wolff JE, Molenkamp G, Westphal S, et al. Oral trofosfamide and etoposide in pediatric patients with glioblastoma multiforme. Cancer. 2000;89:2131-2137.
2. Wolff JE, Wagner S, Sindichakis M, et al. Simultaneous radiochemotherapy in pediatric patients with high-grade glioma: a phase I study. Anticancer Res. 2002;22:3569-3572.
3. Wagner S, Reinert C, Schmid HJ, et al. High-dose methotrexate prior to simultaneous radiochemotherapy in children withmalignant high-grade gliomas. Anticancer Res. 2005;25:2583-2587.
4. Wolff JE, Denecke J, Jurgens H. Dexamethasone induces partial resistance to cisplatinum in C6 glioma cells. Anticancer Res. 1996;16:805-809.
5. Pötter R, Diekmann K. Strahlentherapie. In: Gadner H, Gaedicke G, Niemeyer C, Ritter J, eds. Pädiatrische Hämatologie und Onkologie. Heidelberg: Springer Medizin Verlag; 2005:578-603.
6. Brachman DG, Ashby LS (chairs): RTOG 0513 (A phase I/II trial of temozolomide, motexafin gadolinium and 60 Gy fractionated radiation for newly diagnosed supratentorial glioblastoma multiforme), published online at http://www.rtog.org/members/protocols/0513/0513.pdf.
7. Witt O, Schweigerer L, Driever PH, et al. Valproic acid treatment of glioblastoma multiforme in a child. Pediatr Blood Cancer. 2004;43:181-183.