Inhibition of the ERK pathway promotes apoptosis induced by 2-chloro-2′-deoxyadenosine in the B-cell leukemia cell line eheb

Nucleosides, Nucleotides and Nucleic Acids

Volumn 25, Issue 9-11, 2006, Pages 1009-1012

  Smal, C ^a   Lisart, S ^a   Ferrant, A ^b   Bontemps, F ^a   Van Den Neste, E ^a,b  

^a DE DUVE INSTITUTE   (Belgium)

^b CLINIQUES UNIVERSITAIRES SAINT LUC   (Belgium)

Author keywords

B CLL; Cladribine; Lymphocytes; MAPK ERK

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CLADRIBINE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; NUCLEOSIDE DERIVATIVE;

APOPTOSIS; ARTICLE; B CELL LEUKEMIA; CELL LINE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG INHIBITION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IC 50; PROTEIN EXPRESSION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE 3; CELL LINE, TUMOR; CLADRIBINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; ENZYME INHIBITORS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; INHIBITORY CONCENTRATION 50; LYMPHOMA, B-CELL; PHOSPHORYLATION;

EID: 33750485389     PISSN: 15257770     EISSN: 15322335     Source Type: Journal    
DOI: 10.1080/15257770600894311     Document Type: Article

References (7)

1. Pettitt, A.R. Mechanism of action of purine analogues in chronic lymphocytic leukaemia. Br. J. Haematol. 2003, 121, 692-702.
2. Van Den Neste, E.; Cardoen, S.; Offner, F.; Bontemps, F. Old and new insights into the mechanisms of action of two nucleoside analogs active in lymphoid malignancies: fludarabine and cladribine (review). Int. J. Oncol. 2005, 27, 1113-1124.
3. Chang, L.; Karin, M. Mammalian MAP kinase signalling cascades. Nature 2001, 410, 37-40.
4. Saltman, D.; Bansal, N.S.; Ross, F.M.; Ross, J.A.; Turner, G.; Guy, K. Establishment of a karyotypically normal B-chronic lymphocytic leukemia cell line; evidence of leukemic origin by immunoglobulin gene rearrangement. Leuk. Res. 1990, 14, 381-387.
5. Cardoen, S.; Van Den Neste, E.; Smal, C.; Rosier, J.-F.; Delacauw, A.; Ferrant, A.; Van Den Berghe, G.; Bontemps, F. Resistance to 2-chloro-2′- deoxyadenosine of the human B-cell leukemia cell line EHEB. Clin. Cancer Res. 2001, 7, 3559-3566.
6. English, J.M.; Cobb, M.H. Pharmacological inhibitors of MAPK pathways. Trends Pharmacol. Sci. 2002, 23, 40-45.
7. Fan, M.; Chambers, T.C. Role of mitogen-activated protein kinases in the response of tumor cells to chemotherapy. Drug Resistance Updates 2001, 5, 253-267.