Determination of 5-fluorouracil in plasma with HPLC-tandem mass spectrometry

Nucleosides, Nucleotides and Nucleic Acids

Volumn 25, Issue 9-11, 2006, Pages 1257-1260

  Van Kuilenburg, A B P ^a   Van Lenthe, H ^a   Maring, J G ^b   Van Gennip, A H ^c  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b Diaconessen Hospital   (Netherlands)

^c MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

5 Fluorouracil; Dihydropyrimidine dehydrogenase; Pharmacokinetics

Indexed keywords

FLUOROURACIL;

ARTICLE; CONTROLLED STUDY; DRUG MONITORING; ELECTROSPRAY; HUMAN; ISOTOPE LABELING; MASS SPECTROMETRY; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

ANTIMETABOLITES, ANTINEOPLASTIC; ANTINEOPLASTIC AGENTS; AREA UNDER CURVE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIHYDROURACIL DEHYDROGENASE (NADP); DRUG MONITORING; FLUOROURACIL; HUMANS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TIME FACTORS;

EID: 33750469726     PISSN: 15257770     EISSN: 15322335     Source Type: Journal    
DOI: 10.1080/15257770600894741     Document Type: Article

References (3)

1. van Kuilenburg, A.B.P. Dihydropyrimidine dehydrogenase and the efficacy and toxicity of 5-fluorouracil. Eur. J. Cancer 2004, 40, 939-950.
2. Maring, J.G.; van Kuilenburg, A. B. P.; Haasjes, J.; Piersma, H.; Groen, H.J.M.; Uges, D.R.A.; van Gennip, A.H.; de Vries, E.G.E. Reduced 5-FU clearance in a patient with low DPD activity due to heterozygosity for a mutant allele of the DPYD gene. Br. J. Cancer 2002, 86, 1028-1033.
3. Maring, J.G.; Schouten, L.; Greijdanus, B.; de Vries, E.G.E.; Uges, D.R.A. A simple and sensitive fully validated HPLC-UV method for determination of 5-fluorouracil and its metabolite 5,6-dihydrouracil in plasma. Ther. Drug Monit. 2005, 27, 25-30.