Lymphatic regeneration across an incisional wound: Inhibition by dexamethasone and aspirin, and acceleration by a micronized purified flavonoid fraction

European Journal of Pharmacology

Volumn 551, Issue 1-3, 2006, Pages 131-142

  Greco, Karin Vicente ^a   Lara, Pedro Fernandes ^a   Oliveira Filho, Ricardo Martins ^a   Greco, Rômulo Vicente ^a   Sudo Hayashi, Lia Siguemi ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Acetylsalicylic acid; Dexamethasone; Inflammation; Lymphatic regeneration; Micronized purified flavonoid fraction

Indexed keywords

ACETYLSALICYLIC ACID; DAFLON; DEXAMETHASONE; DEXTRAN; EVANS BLUE; FLAVANOID; TECHNETIUM 99M;

ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; AXILLARY LYMPH NODE; CONTROLLED STUDY; DRUG PURIFICATION; FLOW KINETICS; INFLAMMATION; LYMPH FLOW; LYMPH VESSEL; LYMPHANGIOGENESIS; LYMPHOSCINTIGRAPHY; MALE; MODULATION; NONHUMAN; PHARMACOLOGICAL STIMULATION; PRIORITY JOURNAL; RAT; STIMULUS RESPONSE; SURGICAL WOUND; THIGH;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ASPIRIN; DEXAMETHASONE; DEXTRANS; EVANS BLUE; FLAVONOIDS; INDICATORS AND REAGENTS; INFLAMMATION; LYMPHANGIOGENESIS; LYMPHATIC SYSTEM; MALE; ORGANOTECHNETIUM COMPOUNDS; RADIOPHARMACEUTICALS; RATS; RATS, WISTAR; REGENERATION; TIME FACTORS; WOUND HEALING;

EID: 33750469394     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2006.08.090     Document Type: Article

References (59)

1. Alitalo K., Tammela T., and Petrova T.V. Lymphangiogenesis in development and human disease. Nature 438 (2005) 946-953
2. Allen J.M., Burke E.P., Johnston M.G., and McHale N.G. The inhibitory effect of aspirin on lymphatic contractility. Br. J. Pharmacol. 82 (1984) 509-514
3. Amann R., and Peskar B.A. Anti-inflammatory effects of aspirin and sodium salicylate. Eur. J. Pharmacol. 447 (2002) 1-9
4. Anthony J.P., Foster R.D., Price D.C., Mahdavian M., and Inoue Y. Lymphatic regeneration following microvascular limb replantation: a qualitative and quantitative animal study. J. Reconstr. Microsurg. 13 (1997) 327-330
5. Auerbach W., and Auerbach R. Angiogenesis inhibition: a review. Pharmacol. Ther. 63 (1994) 265-311
6. Auphan N., DiDonato J.A., Rosette C., Hemberg A., and Karin M. Immunosuppression by glucocorticoids: inhibition of NF-kappaB activity through induction of IkappaB synthesis. Science 270 (1995) 286-290
7. Boardman K.C., and Swartz M.A. Interstitial flow as a guide for lymphangiogenesis. Circ. Res. 92 (2003) 801-808
8. Bouskela E., Donyo K.A., and Verbeuren T.J. Effects of Daflon 500 mg on increased microvascular permeability in normal hamster. Int. J. Microcirc. Clin. Exp. 15 Suppl.1 (1995) 22-26
9. Cao Y., Linden P., Shima D., Browne F., and Folkman J. In vivo angiogenic activity and hypoxia induction of heterodimers of placenta growth factor/vascular endothelial growth factor. J. Clin. Invest. 98 (1996) 2507-2511
10. Cavriani G., Domingos H.V., Soares A.L., Trezena A.G., Ligeiro-Oliveira A.P., Oliveira-Filho R.M., Sudo-Hayashi L.S., and Tavares de Lima W. Lymphatic system as a path underlying the spread of lung and gut injury after intestinal ischemia-reperfusion in rats. Shock 23 (2005) 330-336
11. Clark E.R., and Clark E.L. Observations on the new growth of lymphatic vessels as seen in transparent chambers introduced into the rabbit's ear. Am. J. Anat. 51 (1932) 49-87
12. Coleridge-Smith P., Lok C., and Ramelet A.-A. Venous leg ulcer: a meta-analysis of adjunctive therapy with micronized purified flavonoid fraction. Eur. J. Vasc. Endovasc. Surg. 30 (2005) 198-208
13. Coussens L.M., and Werb Z. Inflammation and cancer. Nature 420 (2002) 860-867
14. Cross M.J., Dixelius J., Matsumoto T., and Claesson-Welsh L. VEGF-receptor signal transduction. Trends Biochem. Sci. 28 (2003) 488-494
15. Escribano M., Molero L., López-Farré A., Abarrategui C., Carrasco C., García-Mendez A., Manzarbeitia F., Martín M.J., Vázquez M., Sánchez-Fayos P., Rico L., and Porres-Cubero J.C. Aspirin inhibits endothelial nitric oxide synthase (eNOS) and Flk-1 (vascular endothelial growth factor receptor-2) prior to rat colon tumour development. Clin. Sci. 106 (2004) 83-91
16. Faries M.B., Bedrosian I., Reynolds C., Nguyen H.Q., Alavi A., and Czerniecki B.J. Active macromolecule uptake by lymph node antigen-presenting cells: a novel mechanism in determining sentinel lymph node status. Ann. Surg. Oncol. 7 (2000) 98-105
17. Fierro I.M., Kutok J.L., and Serhan C.N. Novel lipid mediator regulators of endothelial cell proliferation and migration: aspirin-triggered-15R-lipoxin A4 and lipoxin A4. J. Pharmacol. Exp. Ther. 300 (2002) 385-392
18. Gerrah R., Fogel M., and Gilon D. Aspirin decreases vascular endothelial growth factor release during myocardial ischemia. Int. J. Cardiol. 94 (2004) 25-29
19. Ghezzo F., Cesano L., Mognetti B., Pesce E., Pirro E., Corvetti G., Berta G.N., Zingaro B., and Di Carlo F. Salicylate inhibition of rat mammary carcinogenesis and angiogenesis in female rat compatible with misoprostol administration. Int. J. Oncol. 26 (2005) 697-702
20. Harada M., Takeuchi M., Fukao T., and Katagiri K. A simple method for the quantitative extraction of dye extravasated into the skin. J. Pharm. Pharmacol. 23 (1971) 218-219
21. Hoffer E.K., Bloch R.D., Mulligan M.S., Borsa J.J., and Fontaine A.B. Treatment of chylothorax: percutaneous catheterization and embolization of the thoracic duct. Am. J. Roentgenol. 176 (2001) 1040-1042
22. Hong Y.-K., Lange-Asschenfeldt B., Velasco P., Hirakawa S., Kunstfeld R., Brown L.F., Bohlen P., Senger D.R., and Detmar M. VEGF-A promotes tissue repair-associated lymphatic vessel formation via VEGFR-2 and the α1β1 and α2β1 integrins. FASEB J. 18 (2004) 1111-1113
23. Janatpour M.J., Hudak S., Sathe M., Sedgwick J.D., and McEvoy L.M. Tumor necrosis factor-dependent segmental control of MIG expression by high endothelial venules in inflamed lymph nodes regulates monocyte recruitment. J. Exp. Med. 194 (2001) 1375-1384
24. Jones M.K., Wang H., Peskar B.M., Levin E., Itani R.M., James Sarfeh I., and Tarnawski A.S. Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: insight into mechanisms and implications for cancer growth and ulcer healing. Nat. Med. 5 (1999) 1418-1423
25. Karkkainen M.J., Mäkinen T., and Alitalo K. Lymphatic endothelium: a new frontier of metastasis research. Nat. Cell Biol. 4 (2002) E2-E5
26. Kawamura M., Hatanaka K., Saito M., Ogino M., Ono T., Ogino K., Matsuo S., and Harada Y. Are the anti-inflammatory effects of dexamethasone responsible for inhibition of the induction of enzyme involved in prostanoid formation in rat carrageenin-induced pleurisy?. Eur. J. Pharmacol. 400 (2000) 127-135
27. Kaya M., Tuna H., Firat M.F., Tuna F., Seren G., and Yigitbasi O.N. Tc-99m-dextran scintigraphy to detect disease activity in patients with rheumatoid arthritis. Nucl. Med. Commun. 25 (2004) 597-601
28. Kopp E., and Ghosh S. Inhibition of NF-κB by sodium salicylate and aspirin. Science 265 (1994) 956-959
29. Kriederman B.M., Myloyde T.L., Witte M.H., Dagenais S.L., Witte C.L., Rennels M., Bernas M.J., Lynch M.T., Erickson R.P., Caulder M.S., Miura N., David Jackson D., Brooks B.P., and Glover T.W. FOXC2 haploinsufficient mice are a model for human autosomal dominant lymphedema-distichiasis syndrome. Hum. Mol. Genet. 12 (2003) 1179-1185
30. Labrid C. Pharmacologic properties of daflon 500 mg. Angiology 45 (1994) 524-530
31. Mäkinen T., Veikkola T., Mustjoki S., Karpanen T., Catimel B., Nice E.C., Wisel L., Mercer A., Kowalski H., Kerjaschki D., Stacker S.A., Achen M.G., and Alitalo K. Isolated lymphatic endothelial cell transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3. EMBO J. 20 (2001) 4762-4773
32. Mallick A., and Bodenham A.R. Disorders of the lymph circulation: their relevance to anaesthesia and intensive care. Br. J. Anaesth. 91 (2003) 265-272
33. Mariani G., Gipponi M., Moresco L., Villa G., Bartolomei M., Mazzarol G., Bagnara M.C., Romanini A., Cafiero F., Paganelli G., and Strauss H.W. Radioguided sentinel lymph node biopsy in malignant cutaneous melanoma. J. Nucl. Med. 43 (2002) 811-827
34. Maruyama K., li M., Cursiefen C., Jackson D.G., Keino H., Tomita M., Van Rooijen N., Takenaka H., D'Amore P.A., Stein-Streilein J., Losordo D.W., and Streilein J.W. Inflammation-induced lymphangiogenesis in the cornea arises from CD11b-positive macrophages. J. Clin. Invest. 115 (2005) 2363-2372
35. Moriguchi P., Sannomiya P., Lara P.F., Oliveira-Filho R.M., Greco K.V., and Sudo-Hayashi L.S. Lymphatic system changes in diabetes mellitus: role of insulin and hyperglycemia. Diabetes/Metab. Res. Rev. 21 (2005) 150-157
36. Nauck M., Karakiulakis G., Perruchoud A.P., Papakonstantinou E., and Roth M. Corticosteroids inhibit the expression of the vascular endothelial growth factor gene in human vascular smooth muscle cells. Eur. J. Pharmacol. 341 (1998) 309-315
37. Nicolae M., Tircol M., and Alexandru D. Inhibitory effect of acetylsalicylic acid on matrix metalloproteinase-2 activity in human endothelial cells exposed to high glucose. J. Cell. Mol. Med. 9 (2005) 953-960
38. Olfert E.D., Cross B.M., and McWilliam A.A. Canadian Council on Animal Care's/Guide to the Care and Use of Experimental Animals. 2nd ed. (1993), Bradda Printing Services, Ottawa, Ontario, Canada
39. Olszewski W. Clinical efficacy of micronized purified flavonoid fraction (MPFF) in edema. Angiology 51 (2000) 25-29
40. Paavonen K., Puolakkainen P., Jussila L., Jahkola T., and Alitalo K. Vascular endothelial growth factor receptor-3 in lymphangiogenesis in wound healing. Am. J. Pathol. 156 (2000) 1499-1504
41. Pepper M.S., Tille J.-C., Nisato R., and Skobe M. Lymphangioigenesis and tumor metastasis. Cell Tissue Res. 314 (2003) 167-177
42. Pullinger B.D., and Florey H.W. Proliferation of lymphatics in inflammation. J. Pathol. Bacteriol. 45 (1937) 157-170
43. Pytowski B., Goldman J., Persaud K., Wu Y., Witte L., Hicklin D.J., Skobe M., Boardman K.C., and Swartz M.A. Complete and specific inhibition of adult lymphatic regeneration by a novel VEGFR-3 neutralizing antibody. J. Natl. Cancer Inst. 97 (2005) 14-21
44. Redondo S., Santos-Gallego C.G., Ganado P., García M., Rico L., Del Rio M., and Tejerina T. Acetylsalicylic acid inhibits cell proliferation by involving transforming growth factor-β. Circulation 107 (2003) 626-629
45. Ristimäki A., Narko K., Enholm B., Joukov V., and Alitalo K. Proinflammatory cytokines regulate expression of the lymphatic endothelial mitogen vascular endothelial growth factor-C. J. Biol. Chem. 273 (1998) 8413-8418
46. Roy H., Bhardwaj S., and Ylä-Herttuala S. Biology of vascular endothelial growth factors. FEBS Lett. 580 (2006) 2879-2887
47. Rutkowski J.M., Boardman K.C., and Swartz M.A. Characterization of lymphangiogenesis in a model of adult skin regeneration. Am. J. Physiol, Heart Circ. Physiol. 291 (2006) H1401-H1410
48. 2 are mediated by up-regulation of CXCR4 on human microvascular endothelial cells. Blood 102 (2003) 1966-1977
49. Schier F., Uner A., and Waldschmidt J. Microlymphography of spontaneous lymph vessel anastomosis in small bowel transplantation in the rat. J. Pediatr. Surg. 26 (1991) 1239-1242
50. Skobe M., and Detmar M. Structure, function, and molecular control of the skin lymphatic system. J. Investig. Dermatol. Symp. Proc. 5 (2000) 14-19
51. Struckmann J.R. Clinical efficacy of micronized purified flavonoid fraction: an overview. J. Vasc. Res. 36 suppl 1 (1999) 37-41
52. Swartz M.A. The physiology of the lymphatic system. Adv. Drug Deliv. Rev. 50 (2001) 3-20
53. Tilney N.L. Patterns of lymphatic drainage in the adult laboratory rat. J. Anat. 109 (1971) 369-383
54. Tsai P.-W., Shiah S.-G., Lin M.-T., Wu C.-W., and Kuo M.-L. Up-regulation of vascular endothelial growth factor C in breast cancer cells by heregulin-β1. A critical role of p38/nuclear factor-κB signaling pathway. J. Biol. Chem. 278 (2003) 5750-5759
55. Tsopelas C., and Sutton R. Why certain dyes are useful for localizing the sentinel lymph node. J. Nucl. Med. 43 (2002) 1377-1382
56. Veikkola T., Jussila L., Maniken T., Karpanen T., Jeltsch M., Petrova T.V., Kubo H., Thurston G., McDonald D.M., Achen M.G., Stacker S.A., and Alitalo K. Signalling via vascular endothelial growth factor receptor-3 is sufficient for lymphangiogenesis in transgenic mice. EMBO J. 20 (2001) 1223-1231
57. von der Weid P.-Y. Review article: lymphatic vessel pumping and inflammation - the role of spontaneous constrictions and underlying electrical pacemaker potentials. Aliment. Pharmacol. Ther. 15 (2001) 1115-1129
58. 2 in endothelial cells via p42/p44 mitogen-activated protein kinase. FEBS Lett. 420 (1997) 28-32
59. Witte M.H., Bernas M.J., Martin C.P., and Witte C.L. Lymphangiogenesis and lymphangiodysplasia: from molecular to clinical lymphology. Microsc. Res. Tech. 55 (2001) 122-145