Knockdown of amyloid precursor protein normalizes cholinergic function in a cell line derived from the cerebral cortex of a trisomy 16 mouse: An animal model of Down syndrome

Journal of Neuroscience Research

Volumn 84, Issue 6, 2006, Pages 1303-1310

  Opazo, Patricia ^a,b   Saud, Katherine ^a   De Saint Pierre, Michelle ^a   Cárdenas, Ana María ^c   Allen, David D ^d   Segura Aguilar, Juan ^a   Caviedes, Raúl ^a   Caviedes, Pablo ^a  

^a UNIVERSITY OF CHILE   (Chile)

^b PONTIFICIA UNIVERSIDAD CATÓLICA DE VALPARAÍSO   (Chile)

^c UNIVERSIDAD DE VALPARAÍSO   (Chile)

^d NORTHEAST OHIO MEDICAL UNIVERSITY   (United States)

Author keywords

Acetylcholine; Amyloid; Antisense; Cell line; Down syndrome

Indexed keywords

ACETYLCHOLINESTERASE; AMYLOID PRECURSOR PROTEIN; CHOLINE ACETYLTRANSFERASE; GLUTAMIC ACID; NICOTINE; SUPEROXIDE DISMUTASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CELL; BRAIN CORTEX; CELL LINE; CELL MEMBRANE DEPOLARIZATION; CHOLINE UPTAKE; CHOLINERGIC ACTIVITY; CONTROLLED STUDY; DOWN SYNDROME; GENE OVEREXPRESSION; GENETIC TRANSFECTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SECRETION; TRISOMY 16; WESTERN BLOTTING;

ACETYLCHOLINE; ALGORITHMS; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BLOTTING, WESTERN; CELL LINE; CEREBRAL CORTEX; CHOLERA TOXIN; CHOLINE; DOWN SYNDROME; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GLUTAMIC ACID; MICE; NICOTINE; PARASYMPATHETIC NERVOUS SYSTEM; POTASSIUM CHLORIDE; RNA, ANTISENSE; RNA, MESSENGER; SUPEROXIDE DISMUTASE; TRISOMY;

EID: 33750464821     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.21035     Document Type: Article

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