Inhaled nitric oxide attenuates hyperoxic and inflammatory injury without alteration of phosphatidylcholine synthesis in rat lungs

Pulmonary Pharmacology and Therapeutics

Volumn 20, Issue 1, 2007, Pages 75-84

  Hu, Xiaowei ^a   Guo, Chunbao ^a   Sun, Bo ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Hyperoxia; Nitric oxide; Nuclear factor B; Phosphatidylcholine; Phospholipid synthesis; Pulmonary surfactants

Indexed keywords

ALBUMIN; CHOLINE; GLUTATHIONE; MALONALDEHYDE; MYELOPEROXIDASE; NITRIC OXIDE; OXYGEN; PHOSPHATIDYLCHOLINE; PHOSPHOLIPID; SURFACTANT PROTEIN A; TRITIUM;

AMBIENT AIR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE MODEL; DRY WEIGHT; HYPEROXIA; INFLAMMATION; LEUKOCYTE COUNT; LUNG INJURY; LUNG LAVAGE; LUNG PARENCHYMA; LUNG WEIGHT; MALE; MORPHOLOGY; NONHUMAN; PRIORITY JOURNAL; RAT; VASCULAR LESION;

ADMINISTRATION, INHALATION; ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; BRONCHODILATOR AGENTS; GLUTATHIONE; GLUTATHIONE PEROXIDASE; HYPEROXIA; LIPID PEROXIDATION; MALE; MALONDIALDEHYDE; NEUTROPHIL INFILTRATION; NF-KAPPA B; NITRIC OXIDE; PEROXIDASE; PHOSPHATIDYLCHOLINES; PULMONARY ALVEOLI; PULMONARY SURFACTANT-ASSOCIATED PROTEIN A; RATS; RATS, SPRAGUE-DAWLEY; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; TIME FACTORS;

EID: 33750455519     PISSN: 10945539     EISSN: 15229629     Source Type: Journal    
DOI: 10.1016/j.pupt.2005.12.008     Document Type: Article

References (50)

1. American Academy of Pediatrics Committee on Fetus and Newborn. Use of inhaled nitric oxide. Pediatrics 106 (2000) 344-345
2. Weinberger B., Laskin D.L., Heck D.E., and Laskin J.D. The toxicology of inhaled nitric oxide. Toxicol Sci 59 (2001) 5-16
3. Olivera W.G., Ridge K.M., and Sznajder J.I. Lung liquid clearance and Na, K-ATPase during acute hyperoxia and recovery in rats. Am J Respir Crit Care Med 152 (1995) 1229-1234
4. Nelin L.D., Moshin J., Thomas C., Sasidharan P., and Dawson C. The effect of inhaled nitric oxide on the pulmonary circulation of the neonatal pig. Pediatr Res 35 (1994) 20-24
5. Grisham M.B., Jourd'Heuil D., and Wink D.A. Nitric oxide. I. Physiological chemistry of nitric oxide and its metabolites: implications in inflammation. Am J Physiol Gastrointest Liver Physiol 276 (1999) G315-G321
6. Taylor RW, Zimmerman JL, Dellinger RP, Straube RC, Criner GJ, Davis Jr K, et al. for the Inhaled Nitric Oxide in ARDS Study Group, Low-dose inhaled nitric oxide in patients with acute lung injury. A randomized controlled trial. J Am Med Assoc 2004;291:1603-9.
7. Dobyns E.L., Cornfield D.N., Anas N.G., Fortenberry J.D., Tasker R.C., Lynch A., et al. Multicenter randomized controlled trial of the effects of inhaled nitric oxide therapy on gas exchange in children with acute hypoxemic respiratory failure. J Pediatr 134 (1999) 406-412
8. Schreiber M.D., Gin-Mestan K., Marks J.D., Huo D., Lee G., and Srisuparp P. Inhaled nitric oxide in premature infants with the respiratory distress syndrome. New Engl J Med 349 (2003) 2099-2107
9. Aikio O., Vuopala K., Pokela M.-L., Andersson S., and Hallman M. Nitrotyrosine and NO synthases in infants with respiratory failure: influence of inhaled NO. Pediatr Pulmonol 35 (2003) 8-16
10. Hugod C. Effect of exposure to 43 ppm nitric oxide and 3.6 ppm nitrogen dioxide on rabbit lung. Int Arch Occup Environ Health 42 (1992) 159-167
11. Gutierrez H.H., Nieves B., Chumley P., Rivera A., and Freeman B.A. Nitric oxide regulation of superoxide-dependent lung injury: oxidant-protective actions of endogenously produced and exogenously administered nitric oxide. Free Radic Biol Med 21 (1996) 43-52
12. Rubbo H., Radi R., Trujillo M., Telleri R., Kalyanaraman B., Barnes S., et al. Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation. Formation of novel nitrogen-containing oxidized lipid derivatives. J Biol Chem 269 (1994) 26066-26075
13. Zheng S., Zhang W.Y., Zhu L.W., Lin K., and Sun B. Surfactant and inhaled nitric oxide alleviate acute lung injury induced by intestinal ischemia and reperfusion in rats. J Pediatr Surg 36 (2001) 980-984
14. Zhou B.H., Sun B., Zhou Z.H., Zhu L.W., Fan S.Z., and Lindwall R. Comparison of effects of surfactant and inhaled nitric oxide in rabbits with surfactant-depleted respiratory failure. Act Pharmacol Sin 20 (1999) 691-695
15. Zhou Z.H., Sun B., Lin K., and Zhu L. Prevention of rabbit acute lung injury by surfactant, inhaled nitric oxide and pressure support ventilation. Am J Respir Crit Care Med 161 (2000) 581-588
16. Balaan M.R., Bowman L., Dedhia H.V., and Miles P.R. Hyperoxia-induced alterations of rat alveolar lavage composition and properties. Exp Lung Res 21 (1995) 141-156
17. Bhandari V., Johnson L., Smith-Kirwin S., Vigliotta G., Funanage V., and Chander A. Hyperoxia and nitric oxide reduce surfactant components (DSPC and surfactant proteins) and increase apoptosis in adult and fetal rat type II penumocytes. Lung 180 (2003) 301-317
18. Novotny W.E., Hudak B.B., Matalon S., and Holm B.A. Hyperoxic lung injury reduces exogenous surfactant clearance in vivo. Am J Respir Crit Care Med 151 (1995) 1843-1847
19. Matalon S., DeMarco V., Haddad I.Y., Myles C., Skimming J.W., Schurch S., et al. Inhaled nitric oxide injures the pulmonary surfactant system of lambs in vivo. Am J Physiol 270 (1996) L273-L280
20. Issa A., Lappalainen U., Kleinman M., Bry K., and Hallman M. Inhaled nitric oxide decreases hyperoxia-induced surfactant abnormality in preterm rabbits. Pediatr Res 45 (1999) 247-254
21. Haddad I.Y., Zhu S., Crow J., Barefield E., Gadilhe T., and Matalon S. Inhibition of alveolar type II cell ATP and surfactant synthesis by nitric oxide. Am J Physiol Lung Cell Mol Physiol 270 (1996) L898-L906
22. Johnson-Varghese L., Brodsky N., and Bhandari V. Effects of antioxidants on apoptosis and cytokine release in fetal rat type II pneumocytes exposed to hyperoxia and nitric oxide. Cytokine 28 (2004) 10-16
23. Lightfoot R.T., and Khov S. Ischiropoulos. Transient injury to rat lung mitochondrial DNA after exposure to hyperoxia and inhaled nitric oxide. Am J Physiol Lung Cell Mol Physiol 286 (2004) L23-L29
24. Ennema J.J., Kobayashi T., Robertson B., and Curstedt T. Inactivation of exogenous surfactant in experimental respiratory failure induced by hyperoxia. Acta Anaesthesiol Scand 32 (1988) 665-671
25. Tietze F. Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to blood and other tissues. Anal Biochem 27 (1969) 502-522
26. Paglia D.E., and Valentine W.N. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 70 (1967) 158-169
27. Zhang H., Lindwall R., Frostell C., Zhu L.W., and Sun B. Lung physiology and histopathology after prolonged nitric oxide exposure in combination with assisted ventilation in healthy piglets. Pulmon Pharmacol Therap 16 (2003) 163-169
28. Bartlett G.B. Phosphorous assay in column chromatography. J Biol Chem 234 (1959) 466-468
29. Mason R.J., Nellenbogen J., and Clements J.A. Isolation of disaturated phosphatidylcholine with osmium tetroxide. J Lipid Res 17 (1976) 281-284
30. Lowry O.H., Rosebrough N.J., Farr A.L., and Randall R.J. Protein measurement with the Folin phenol reagent. J Biol Chem 193 (1951) 265-275
31. Cao L., Liu C., Cai B., Jia X., Kang L., Speer C.P., et al. Nuclear factor-kappa B expression in alveolar macrophages of mechanically ventilated neonates with respiratory distress syndrome. Biol Neonat 86 (2004) 116-123
32. Jobe A., Kirkpatrick E., and Gluck L. Labeling of phospholipids in the surfactant and subcellular fractions of rabbit lung. J Biol Chem 253 (1978) 3810-3816
33. Howlett C.E., Hutchison J.S., Veinot J.P., Merchant P., and Fliss H. Inhaled nitric oxide protests against hypoxia-induced apoptosis in rat lungs. Am J Physiol Lung Cell Mol Physiol 277 (1999) L596-L605
34. Freeman B.A., Mason R.J., Williams M.C., and Crapo J.D. Antioxidant enzyme activity in alveolar type II cells after exposure of rats to hyperoxia. Exp Lung Res 10 (1986) 203-222
35. Nelin L.D., Welty S.E., Morrisey J.F., Gotuaco C., and Dawson C.A. Nitric oxide increases the survival of rats with a high oxygen exposure. Pediatr Res 43 (1998) 727-732
36. McElroy M.C., Wiener-Kronish J.P., Miyazaki H., Sawa T., Modelska K., Dobbs L.G., et al. Nitric oxide attenuates lung endothelial injury caused by sublethal hyperoxia in rats. Am J Physiol Lung Cell Mol Physiol 272 (1997) L631-L638
37. Clark R.H., Kueser T.J., Walker M.W., Southgate W.M., Huckaby J.L., Perez J.A., et al. Low-dose nitric oxide therapy for persistent pulmonary hypertension of the newborn. N Engl J Med 342 (2000) 469-474
38. Davidson D., Barefield E.S., Kattwinkel J., Dudell G., Damask M., Straube R., et al. Inhaled nitric oxide for the early treatment of persistent pulmonary hypertension of the term newborn: a randomized, double-masked, placebo-controlled, dose-response, multicenter study. The I-NO/PPHN Study Group. Pediatrics 101 (1998) 325-334
39. Rahman I., Li X.Y., Donaldson K., Harrison D.J., and MacNee W. Glutathione homeostasis in alveolar epithelial cells in vitro and lung in vivo under oxidative stress. Am J Physiol 269 (1995) L285-L292
40. Honda K., Kobayashi H., Hataishi R., Hirano S., Fukuyama N., Nakazawa H., et al. Inhaled nitric oxide reduces tyrosine nitration after lipopolysaccharide instillation into lungs of rats. Am J Respir Crit Care Med 160 (1999) 678-688
41. Weigand M.A., Snyder-Ramos S.A., Mollers A.G., Bauer J., Hansen D., Kochen W., et al. Inhaled nitric oxide does not enhance lipid peroxidation in patients with acute respiratory distress syndrome. Crit Care Med 28 (2000) 3429-3435
42. Kobayashi H., Hataishi R., Mitsufuji H., Tanaka M., Jacobson M., Tomita T., et al. Antiinflammatory properties of inducible nitric oxide synthase in acute hyperoxic lung injury. Am J Respir Cell Mol Biol 24 (2001) 390-397
43. Capellier G., Maupoil V., Boillot A., Kantelip J.-P., Rochette L., Regnard J., et al. L-NAME aggravates pulmonary oxygen toxicity in rats. Eur Respir J 9 (1996) 2531-2536
44. Gries D.M., Tam E.K., Blaisdell J.M., Iwamoto L.M., Fujiwara N., Uyehara C.F., et al. Differential effects of inhaled nitric oxide and hyperoxia on pulmonary dysfunction in newborn guinea pigs. Am J Physiol Regul Integr Comp Physiol 279 (2000) R1525-R1530
45. Ekekezie I.I., Thibeault D.W., Zwick D.L., Rezaiekhaligh M.H., Mabry S.M., Morgan R.E., et al. Independent and combined effects of prolonged inhaled nitric oxide and oxygen on lung inflammation in newborn piglets. Biol Neonate 77 (2000) 37-44
46. Hallman M., Waffarn F., Bry K., Turbow R., Kleinman M.T., Mautz W.J., et al. Surfactant dysfunction after inhalation of nitric oxide. J Appl Physiol 80 (1996) 2026-2034
47. Hallman M., Bry K., Turbow R., Waffarn F., and Lappalainen U. Pulmonary toxicity associated with nitric oxide in term infants with severe respiratory failure. J Pediatr 132 (1998) 827-829
48. Nogee L.M., Wispe J.R., Clark J.C., and Whitsett J.A. Increased synthesis and mRNA of surfactant protein A in oxygen-exposed rats. Am J Respir Cell Mol Biol 1 (1989) 119-125
49. Stuart R.B., Ovadia B., Suzara V.V., Ross P.A., Thelitz S., Fineman J.R., et al. Inhaled nitric oxide increases surfactant protein gene expression in the intact lamb. Am J Physiol Lung Cell Mol Physiol 285 (2003) L628-L633
50. Haddad I.Y., Zhu S., Crow J., Barefield E., Gadilhe T., and Matalon S. Inhibition of alveolar type II cell ATP and surfactant synthesis by nitric oxide. Am J Physiol 270 (1996) L898-L906