An experimental study of telomerase reverse transcriptase (hTERT) DNAzyme on growth of A549/DDP cells

Chinese Journal of Lung Cancer

Volumn 9, Issue 5, 2006, Pages 405-408

  Yu, Bingxiang ^a   Zhu, Jie ^b   Liu, Youning ^b   Zheng, Xiaofei ^b  

^a CHINESE PLA GENERAL HOSPITAL   (China)

^b NONE

Author keywords

DNAzyme; Drug resistance; Lung neoplasms; Telomerase

Indexed keywords

CISPLATIN; TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE;

ARTICLE; CANCER CELL; CELL GROWTH; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; DRUG POTENTIATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LUNG CANCER; TELOMERIC REPEAT AMPLIFICATION PROTOCOL;

EID: 33750450495     PISSN: 10093419     EISSN: 19996187     Source Type: Journal    
DOI: None     Document Type: Article

References (9)

1. Kawai H, Kiura K, Tabata M, et al. Characterization of non-small-cell lung cancer cell lines established before and after chemotherapy. Lung Cancer, 2002, 35(3): 305-314.
2. Jaattela M. Escaping cell death: survival proteins in cancer. Exp Cell Res, 1999, 248(1): 30-43.
3. Wang J, Liu XY, Wu MN, et al. Expression and reversion of drug resistance- and apoptosis-related genes of a DDP-resistant lung adenocarcionma cell line A549/DDP. Chin J Oncol, 1999, 21(6): 422-426.
4. Mandal M, Kumar R. Bcl-2 modulates telomerase activity. J Biol Chem,1997, 272(22): 14183-14187.
5. Tormanen U, Eerola AK, Rainio P, et al. Enhanced apoptosis predicts shortened survival in non-small cell lung carcinoma. Cancer Res, 1995, 55(23): 5595-5602.
6. Breaker RR. Joyce GF. A DNA enzyme that cleaves RNA. Chem Biol, 1994, 1(4): 223-229.
7. Santoro SW, Joyce GF. A general purpose RNA-cleaving DNA enzyme. Proc Natl Acad Sci U S A, 1997, 94(9): 4262-4266.
8. Kondo Y, Kondo S, Tanaka Y, et al. Inhibition of telomerase increases the susceptibility of human malignant glioblastoma cells to cisplatin-induced apoptosis. Oncogene, 1998, 16(17): 2243-2248.
9. Xiao Y, Zhang H. Effect of antisense oligodeoxynucleotides of RNA component of human telomerase on cisplatin induced apoptosis in K562 cells. J First Mil Med Univ, 2003, 23(2): 144-147.