Royal jelly stimulates bone formation: Physiologic and nutrigenomic studies with mice and cell lines

Bioscience, Biotechnology and Biochemistry

Volumn 70, Issue 10, 2006, Pages 2508-2514

  Narita, Yukio ^a   Nomura, Johji ^b   Ohta, Shozo ^a   Inoh, Yoshikazu ^a   Suzuki, Kazu Michi ^a   Araki, Yoko ^a   Okada, Shinji ^c   Matsumoto, Ichiro ^c   Isohama, Yoichiro ^b   Abe, Keiko ^c   Miyata, Takeshi ^b   Mishima, Satoshi ^a  

^a Api Company Ltd   (Japan)

^b KUMAMOTO UNIVERSITY   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

Bone ash; MC3T3 E1; Royal jelly; Type I procollagen

Indexed keywords

BIODIVERSITY; BONE; COLLAGEN; GENES; HORMONES; PHARMACODYNAMICS; PHYSIOLOGY;

DNA MICROARRAY ANALYSIS; ORAL ADMINISTRATION; PHARMACOLOGICAL FUNCTIONS; ROYAL JELLY;

FOOD PRODUCTS;

COLLAGEN TYPE 1; FATTY ACID; ROYAL JELLY;

ANIMAL; ARTICLE; BIOSYNTHESIS; BONE DEVELOPMENT; CELL LINE; DNA MICROARRAY; DRUG EFFECT; EXTRACELLULAR MATRIX; FEMALE; GENE EXPRESSION PROFILING; GENETICS; MOUSE; OSTEOBLAST; POLYMERASE CHAIN REACTION; TIBIA; UPREGULATION;

ANIMALS; CELL LINE; COLLAGEN TYPE I; EXTRACELLULAR MATRIX; FATTY ACIDS; FEMALE; GENE EXPRESSION PROFILING; MICE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OSTEOBLASTS; OSTEOGENESIS; POLYMERASE CHAIN REACTION; TIBIA; UP-REGULATION;

EID: 33750446664     PISSN: 09168451     EISSN: 13476947     Source Type: Journal    
DOI: 10.1271/bbb.60240     Document Type: Article

References (20)

1. Mateescu, C., and Barbulescu, D., Enhanced nutritive, functional and therapeutic action of combined bee products in complex food supplements. Roumanian Biotechnol. Lett., 4, 163-172 (1999).
2. Fujii, A., Pharmacological effect of royal jelly. Honeybee Science (in Japanese), 16, 97-104 (1995).
3. Kushima, K., and Hasegawa, N., Menopausal disorder. The Journal of Therapy (in Japanese), 54, 578-584 (1972).
4. Mishima, S., Suzuki, K.-M., Isohama, Y., Kuratsu, N., Araki, Y., Inoue, M., and Miyata, T., Royal jelly has estrogenic effects in vitro and in vivo. J. Ethnopharmacol., 101, 215-220 (2005).
5. Compston, J. E., Sex steroids and bone. Physiol. Rev., 81, 419-447 (2001).
6. Stepan, J. J., Alenfeld, F., Boivin, G., Feyen, J. H., and Lakatos, P., Mechanisms of action of antiresorptive therapies of postmenopausal osteoporosis. Endocr. Regul., 37, 225-238 (2003).
7. Vogelvang, T. E., van der Mooren, M. J., and Mijatovic, V., Hormone replacement therapy, selective estrogen receptor modulators, and tissue-specific compounds: cardiovascular effects and clinical implications. Treat. Endocrinol., 3, 105-115 (2004).
8. Branca, F., Dietary phyto-oestrogens and bone health. Proc. Nutr. Soc., 62, 877-887 (2003).
9. Kanno, S., Hirano, S., and Kayama, F., Effects of phytoestrogens and environmental estrogens on osteoblastic differentiation in MC3T3-E1 cells. Toxicology, 196, 137-145 (2004).
10. Saito, M., Obata, A., Kataoka, S., Izumi, T., Tobe, K., Kikuchi, M., and Ezawa, I., Preventive effects of fermented soy extract containing isoflavone aglycons on bone loss in ovariectomized rats fed on a calcium-deficient diet. J. Home Econ. Jpn., 54, 613-621 (2003).
11. Lee, Y. B., Lee, H. J., Kim, K. S., Lee, J. Y., Nam, S. Y., Cheon, S. H., and Sohn, H. S., Evaluation of the preventive effect of isoflavone extract on bone loss in ovariectomized rats. Biosci. Biotechnol. Biochem., 68, 1040-1045 (2004).
12. Erlandsson, M. C., Islander, U., Moverare, S., Ohlsson, C., and Carlsten, H., Estrogenic agonism and antagonism of the soy isoflavone genistein in uterus, bone and lymphopoiesis in mice. APMIS, 113, 317-323 (2005).
13. Mori-Okamoto, J., Otawara-Hamamoto, Y., Yamato, H., and Yoshimura, H., Pomegranate extract improves a depressive state and bone properties in menopausal syndrome model ovariectomized mice. J. Ethnopharmacol., 92, 93-101 (2004).
14. Takeda, T., Effects of environment on life span and pathological phenotypes in senescence-accelerated mice. In "The Senescence-Accelerated Mouse (SAM): an Animal Model of Senescence," eds. Nomura, Y., Takeda, T., and Okuma, T., Elsevier, Amsterdam, pp. 3-12 (1994).
15. Hosack, D. A., Dennis, G., Jr., Sherman, B. T., Lane, H. C., and Lempicki, R. A., Identifying biological themes within lists of genes with EASE. Genome Biol., 4, R70 (2003).
16. Koya-Miyata, S., Okamoto, I., Ushio, S., and Iwaki, K., Identification of a collagen production-promoting factor from an extract of royal jelly and its possible mechanism. Biosci. Biotechnol. Biochem., 68, 767-773 (2004).
17. Spelsberg, T. C., Subramaniam, M., Riggs, B. L., and Khosla, S., The actions and interactions of sex steroids and growth factors/cytokines on the skeleton. Mol. Endocrinol., 13, 819-828 (1999).
18. Lindberg, M. K., Moverare, S., Eriksson, A. L., Skrtic, S., Gao, H., Dahlman-Wright, K., Gustafsson, J. A., and Ohlsson, C., Identification of estrogen-regulated genes of potential importance for the regulation of trabecular bone mineral density. J. Bone Miner. Res., 17, 2183-2195 (2002).
19. Hammett-Stabler, C. A., The use of biochemical markers in osteoporosis. Clin. Lab. Med., 24, 175-197 (2004).
20. Hidaka, S., Okamoto, Y., Uchiyama, S., Nakatsuma, A., Hashimoto, K., Ohnishi, S. T., and Yamaguchi, M., Royal jelly prevents osteoporosis in rats: beneficial effects in ovariectomy model and in bone tissue culture model. Evid. Based Complement. Altern. Med., 3, 339-348 (2006).