CGH evaluation of two de novo synchronous tumors in a child with a germline p53 mutation

Pediatric Blood and Cancer

Volumn 47, Issue 7, 2006, Pages 949-954

  Roque, Lúcia ^a   Lacerda, Ana ^b   Rodrigues, Raquel ^a   Almeida, Odete ^b   Salgueiro, João ^c   Pinto, Carla ^b  

^a INSTITUTO PORTUGUÊS DE ONCOLOGIA DE LISBOA FRANCISCO GENTIL   (Portugal)

^b Portuguese Cancer Institute   (Portugal)

^c HOSPITAL EGAS MONIZ   (Portugal)

Author keywords

Cancer; Comparative genomic hybridization; Mutation; p53; Synchronous

Indexed keywords

PROTEIN P53;

ARTICLE; CANCER GENETICS; CASE REPORT; CHROMOSOME ANALYSIS; CHROMOSOME DISORDER; COMPARATIVE GENOMIC HYBRIDIZATION; CYTOGENETICS; EMBRYONAL RHABDOMYOSARCOMA; GENE AMPLIFICATION; GENE MUTATION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MALE; OSTEOSARCOMA; PEDIGREE; PRIORITY JOURNAL; SCHOOL CHILD;

CHILD; FEMORAL NEOPLASMS; GENES, P16; GENES, P53; GERM-LINE MUTATION; HUMANS; MALE; NEOPLASMS, MULTIPLE PRIMARY; NUCLEIC ACID HYBRIDIZATION; OSTEOSARCOMA; RETROPERITONEAL NEOPLASMS; RHABDOMYOSARCOMA; TESTICULAR NEOPLASMS;

EID: 33750441522     PISSN: 15455009     EISSN: 15455017     Source Type: Journal    
DOI: 10.1002/pbc.20603     Document Type: Article

References (15)

1. Malkin D. The Li-Fraumeni syndrome. In: Vogelstein B, Kinzler KW, editors. The genetic basis of human cancer. USA: McGraw-Hill Companies, Inc.; 1998. pp 393-407.
2. Bode AM, Dong Z. Post-translational modifications of p53 in tumorigensis. Nat Rev Cancer 2004;4:793-805.
3. Smith MB, Xue H, Strong L, et al. Forty-year experience with second malignancies after treatment of childhood cancer: Analysis of outcome following the development of the second malignancy. J Pediatr Surg 1993;28:1342-1348.
4. Longhi A, Bertoni F, Bacchini P, et al. Simultaneous osteosarcoma lung metastasis and second primary lung cancer. J Pediatr Hematol Oncol 2004;26:457-461.
5. Khayat CM, Johnston DL. Rhabdomyosarcoma, osteosarcoma, and adrenocortical carcinoma in a child with a germline p53 mutation. Pediatric Blood Cancer 2004;6:683-686.
6. Pivnick EK, Furman WL, Velagaleri GVN, et al. Simultaneous adrenocortical carcinoma and ganglioneuroblastoma in a child with Turner syndrome and germline p53 mutation. J Med Genet 1998;35:328-332.
7. Roque L, Rodrigues R, Pinto A, et al. Chromosome imbalances in thyroid follicular neoplasms: A comparison between follicular adenomas and carcinomas. Genes Chromos Cancer 2003;36:292-302.
8. Mulenbach R, Lagoda PJ, Welter C. An efficient salt-chloroform extraction of DNA from blood and tissues. Trends Genet 1989;5:391.
9. Olivier M, Goldgar DE, Sodha N, et al. Li-Fraumeni and related syndromes: Correlation between tumor type, family structure, and TP53 genotype. Cancer Res 2003;63:6643-6650.
10. Squire JA, Pei J, Marrano P, et al. High resolution mapping of amplifications and deletions in pediatric ostoesarcoma by use of CGH analysis of cDNA microaarrays. Genes Chromosomes Cancer 2003;38:215-225.
11. Gorlick R, Anderson P, Andrulis I, et al. Biology of childhood ostoegenic sarcoma and potential targets for therapeutic development: Meeting summary. Clin Cancer Res 2003;9:5442-5453.
12. Wadayama B, Toguchida J, Shimizu T, et al. Mutation spectrum of the retinoblastoma gene in osteosarcomas. Cancer Res 1994;54:3042-3048.
13. Thomas DM, Carty SA, Piscopo DM, et al. The retinoblastoma protein acts as a transcriptional coactivator required for osteogenic differentiation. Moll Cell 2001;8:303-316.
14. Weber-Hall S, Anderson J, McManus A, et al. Gains, losses, and amplification material in rhabdomyosarcoma analysed by comparative genomic hybridisation. Cancer Res 1996;56:3220-3224.
15. Sharp R, Recio JA, Jhappan C, et al. Synergism between INK4a/ARF inactivation and aberrant HGF/SF signalling in rhabdomyo-sarcomagenesis. Nat Med 2002;8:1200-1201.