Anti-hyperalgesic and anti-inflammatory effects of the modified Chinese herbal formula Huo Luo Xiao Ling Dan (HLXL) in rats

American Journal of Chinese Medicine

Volumn 34, Issue 5, 2006, Pages 833-844

  Lao, Lixing ^a   Fan, Arthur Yin ^a   Zhang, Rui Xin ^a   Zhou, Annan ^a   Ma, Zhong Ze ^c   Lee, David Yue Wei ^c,d   Ren, Ke ^b   Berman, Brian ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MARYLAND DENTAL SCHOOL   (United States)

^c MCLEAN HOSPITAL   (United States)

^d Natural Pharmacia International Inc   (United States)

Author keywords

Adverse effects; Chinese herbal medicine; Huo Luo Xiao Ling Dan (HLXL); Hyperalgesia; Inflammation; Rat model

Indexed keywords

ANGELICA SINENSIS EXTRACT; CHINESE DRUG; CINNAMOMUM CASSIA EXTRACT; DRUG VEHICLE; FREUND ADJUVANT; GLYCYRRHIZA URALENSIS EXTRACT; HERBACEOUS AGENT; HUO LUO XIAO LING DAN; LIGUSTICUM EXTRACT; PAEONIA LACTIFLORA EXTRACT; PROTEIN FOS; QIANG HUO; QIN JIAO; RU XIANG; SALVIA MILTIORRHIZA EXTRACT; UNCLASSIFIED DRUG; YAN HU SUO;

ANGELICA PUBESCENS; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE REGIMEN; DRUG EFFECT; HINDLIMB; HYPERALGESIA; IMMUNOHISTOCHEMISTRY; INFLAMMATION; LATENT PERIOD; MALE; NEUROTRANSMISSION; NONHUMAN; PERIPHERAL EDEMA; PHARMACODYNAMICS; PROTEIN EXPRESSION; RAT; SPINAL CORD DORSAL HORN; TOXICITY TESTING;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ARTHRITIS, EXPERIMENTAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUGS, CHINESE HERBAL; EDEMA; FREUND'S ADJUVANT; HINDLIMB; HOT TEMPERATURE; HYPERALGESIA; IMMUNOHISTOCHEMISTRY; MALE; NEURONS; PROTO-ONCOGENE PROTEINS C-FOS; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD;

EID: 33750437307     PISSN: 0192415X     EISSN: None     Source Type: Journal    
DOI: 10.1142/S0192415X06004326     Document Type: Article

References (28)

1. Bausell, R.B. and Y.F. Li. Power Analysis for Experimental Research: A Practical Guide for the Biological, Medical, and Social Sciences. Cambridge University Press, Cambridge, 2002.
2. Bensky, D. and A. Gamble. Chinese Herbal Medicine: Materia Medica, revised ed. Eastland Press, Seattle, 1993, pp. 82-83.
3. Bensky, D. and R. Barolet. Chinese Herbal Medicine: Formulas and Strategies. Eastland Press, Seattle, 1990, pp. 329-330.
4. Cao, H., S.T. Wang, L.Y. Wu, X.T. Wang and A.P. Jiang. Pharmacological study on Tia Xiong (Tuber of Aconitum carmichaeli Debx.): A Chinese drug for reinforcing the Kidney Yang retail in Hong Kong market. Chin. J. Chin. Mater. Med. 26: 369-372, 2001.
5. Fan, A.Y., L. Lao, R.X. Zhang, L.B. Wang, D.Y.W. Lee, Z.Z. Ma, W.Y. Zhang and B. Berman. Effects of an acetone extract of Boswellia carterii Birdw. (Burseraceae) gum resin on rats with persistent inflammation. J. Altern. Complement. Med. 11: 323-331, 2005a.
6. Fan, A.Y., L. Lao, R.X. Zhang, A.N. Zhou, L.B.Wang, K.D. Moudgil, D. Lee, Z.Z. Ma, W.Y. Zhang and B. Berman. Effects of an acetone extract of Boswellia carterii Birdw. (Burseraceae) gum resin on adjuvant-induced arthritis in lewis rats. J. Ethnopharmacol. (E-pub ahead of print), 2005b.
7. Food and Drug Administration (CDER). Guidance for Industry: Botanic Drug Products. www.fda.gov/cder/guidance/4592fnl.htm (2004).
8. Food and Drug Administration. Guidance for Industry and Reviewers: Estimate the Safe Starting Dose in Clinical Trials for Therapeutics in Adult Healthy Volunteers, Appendix A. http://www.fda.gov/cber/gdlns/ dose.htm (2002).
9. Gad, S.C. Drug Safety Evaluation. Wiley-Interscience, New York, 2002, pp. 131-504.
10. Hargreaves, K., R. Dubner, F. Brown, C. Flores and J. Joris. A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain 32: 77-88, 1988.
11. Hunt, S.P., A. Pini and G. Evan. Induction of c-fos-like protein in spinal cord neurons following sensory stimulation. Nature (Lond.) 328: 632-634, 1987.
12. Lao, L., A.Y. Fan, R.X. Zhang, L.B. Wang, Z.Z. Ma, W.Y. Zhang, D. Lee and B.M. Berman. Chinese herb attenuates hyperalgesia and edema in rats with persistent inflammation. J. Altern. Complement. Med. 10: 206-207, 2004.
13. Lao, L., G. Zhang, F. Wei, B.M. Berman and K. Ren. Electro-acupuncture attenuates behavioral hyperalgesia and selectively reduces spinal Fos protein expression in rats with persistent inflammation. J. Pain 2: 111-117, 2001.
14. Morgan, J.I., D.R Cohen, J.L. Hempstead and T. Curran. Mapping patterns of c-fos expression in the central nervous system after seizure. Science 237: 192-197, 1987.
15. Peng, H.R. Zhong Yi Fang Ji Da Ci Dian (Chinese Source, Grand Dictionary of Chinese Medicinal Formula). People's Health Press, Beijing, 1998.
16. Peng, Q.Y. A 132 cases' observation, lumbar spinal osteoarthritis treated by Huo-Luo-Xiao-Lin Dan. J. Clin. Folk Ther. 2: 32-33, 1997.
17. Ren, K. and M.A. Ruda. Descending modulation of Fos expression after persistent peripheral inflammation. Neuroreport 7: 2186-2190, 1996.
18. Shen, Y.J. and R.Y. Sun. The experimental methods of toxicity and safety on Chinese herbal medicine. In: C. Chen (ed.) The Experimental Methodology of Chinese Herbal Medicine. People's Health Press, Beijing, 2000, pp. 117-118.
19. Wan, B.G. and B.H. Tao. An 87 cases' clinical observation, arthritis treated by modified Huo-Luo-Xiao-Ling Dan. J. Jiangxi Trad. Chin. Med. 33: 12, 2002.
20. Wang, G.D., C. Li and S.L. Zhang. An 89 cases' cliical observation: cervical syndrome treated by modified Huo-Luo-Xiao-Lin Dan. J. Trad. Chin. Med. Boneset. 12: 43, 2000.
21. Wang, Y.C., S.Y. Ji and R. Wang The clinical application of Huo Luo Xiao Ling Dan. Acta Trad. Chin. Med. 30: 53, 2002.
22. Wei, F., R. Dubner and K. Ren. Nucleus reticularis gigantocellularis and nucleus raphe magnus in the brain stem exert opposite effects on behavioral hyperalgesia and spinal Fos protein expression after peripheral inflammation. Pain 80: 127-141, 1990.
23. Wei, F., S. Zhou, A. Young, R. Dubner and K. Ren. Effects of four herbal extracts on adjuvant-induced inflammation and hyperalgesia in rats. J. Altern. Complement. Med. 5: 429-436, 1999.
24. WHO. Medicinal Plants-Guidelines to Promote Patient Safety and Plant Conservation for a US$60 Billion Industry. Note for the Press 3, 10 February 2004. WHO Website http://www.who.int/mediacentre/news/notes/ 2004/np3/en
25. Zhang, R.X., R. Wang, J.Y. Cheng and J.T. Qiao. Effects of descending inhibitory systems on the c-fos expression in the rat spinal cord during formalin-induced noxious stimulation. Neuroscience 58: 299-304, 1994.
26. Zhang, X.C. Yi Xue Zhong Zhong Can Xi Lu (Chinese Source, Records of Heartfelt Experiences in Medicine with the Reference to the West), 1918.
27. Zhen, F.M., L.W. Guo, H.M. Bian and S.L. Jin. Effect of four preparation techniques on analgesic and anti-inflammatory effect of Olibanum. J. Nanjing. Univ. TCM 19: 213-214, 2003.
28. Zimmermann, M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain 16: 109-110, 1983.