Hepatocellular adenoma displaying a HNF1α inactivation in a patient with familial adenomatous polyposis coli

Journal of Hepatology

Volumn 45, Issue 6, 2006, Pages 883-886

  Jeannot, Emmanuelle ^a,b   Wendum, Dominique ^c   Paye, François ^c   Mourra, Najat ^c   de Toma, Claudia ^b   Fléjou, Jean François ^c   Zucman Rossi, Jessica ^a,b  

^a INSERM   (France)

^b FONDATION JEAN DAUSSET CEPH   (France)

^c ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS   (France)

Author keywords

Catenin; Familial adenomatosis polyposis coli; Gene mutation; Hepatocellular adenoma; Hepatocyte nuclear factor 1

Indexed keywords

BETA CATENIN; ESTROGEN; HEPATOCYTE NUCLEAR FACTOR 1ALPHA; PROGESTERONE; WNT PROTEIN;

ADULT; ALLELE; ARTICLE; CASE REPORT; COLON POLYPOSIS; COMORBIDITY; DOWN REGULATION; FAMILIAL POLYPOSIS; FEMALE; GENE MUTATION; GENE TARGETING; HUMAN; HUMAN TISSUE; LIVER ADENOMA; LIVER BIOPSY; ORAL CONTRACEPTION; PRIORITY JOURNAL; STEATOSIS; TREATMENT DURATION;

ADENOMATOUS POLYPOSIS COLI; ADULT; ALLELES; CARCINOMA, HEPATOCELLULAR; DIAGNOSIS, DIFFERENTIAL; FEMALE; GENE SILENCING; GENES, APC; GENETIC PREDISPOSITION TO DISEASE; GERM-LINE MUTATION; HEPATOCYTE NUCLEAR FACTOR 1-ALPHA; HUMANS; IMMUNOHISTOCHEMISTRY; LIVER NEOPLASMS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 33750432441     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2006.06.020     Document Type: Article

References (15)

1. Edmondson H.A., Henderson B., and Benton B. Liver-cell adenomas associated with use of oral contraceptives. N Engl J Med 294 (1976) 470-472
2. Terminology of nodular hepatocellular lesions. International Working Party. Hepatology 1995;22:983-993.
3. Bluteau O., Jeannot E., Bioulac-Sage P., Marques J.M., Blanc J.F., Bui H., et al. Bi-allelic inactivation of TCF1 in hepatic adenomas. Nat Genet 32 (2002) 312-315
4. Bacq Y., Jacquemin E., Balabaud C., Jeannot E., Scotto B., Branchereau S., et al. Familial liver adenomatosis associated with hepatocyte nuclear factor 1alpha inactivation. Gastroenterology 125 (2003) 1470-1475
5. Reznik Y., Dao T., Coutant R., Chiche L., Jeannot E., Clauin S., et al. Hepatocyte nuclear factor-1 alpha gene inactivation: cosegregation between liver adenomatosis and diabetes phenotypes in two maturity-onset diabetes of the young (MODY)3 families. J Clin Endocrinol Metab 89 (2004) 1476-1480
6. Chen Y.W., Jeng Y.M., Yeh S.H., and Chen P.J. P53 gene and Wnt signaling in benign neoplasms: beta-catenin mutations in hepatic adenoma but not in focal nodular hyperplasia. Hepatology 36 (2002) 927-935
7. Zucman-Rossi J., Jeannot E., Nhieu J.T., Scoazec J.Y., Guettier C., Rebouissou S., et al. Genotype-phenotype correlation in hepatocellular adenoma: new classification and relationship with HCC. Hepatology 43 (2006) 515-524
8. Groden J., Thliveris A., Samowitz W., Carlson M., Gelbert L., Albertsen H., et al. Identification and characterization of the familial adenomatous polyposis coli gene. Cell 66 (1991) 589-600
9. Joslyn G., Carlson M., Thliveris A., Albertsen H., Gelbert L., Samowitz W., et al. Identification of deletion mutations and three new genes at the familial polyposis locus. Cell 66 (1991) 601-613
10. Bala S., Wunsch P.H., and Ballhausen W.G. Childhood hepatocellular adenoma in familial adenomatous polyposis: mutations in adenomatous polyposis coli gene and p53. Gastroenterology 112 (1997) 919-922
11. Blaker H., Sutter C., Kadmon M., Otto H.F., Von Knebel-Doeberitz M., Gebert J., et al. Analysis of somatic APC mutations in rare extracolonic tumors of patients with familial adenomatous polyposis coli. Genes Chromosomes Cancer 41 (2004) 93-98
12. Laurent-Puig P., Legoix P., Bluteau O., Belghiti J., Franco D., Binot F., et al. Genetic alterations associated with hepatocellular carcinomas define distinct pathways of hepatocarcinogenesis. Gastroenterology 120 (2001) 1763-1773
13. Cadoret A., Ovejero C., Terris B., Souil E., Levy L., Lamers W.H., et al. New targets of beta-catenin signaling in the liver are involved in the glutamine metabolism. Oncogene 21 (2002) 8293-8301
14. Yamamoto Y., Sakamoto M., Fujii G., Tsuiji H., Kenetaka K., Asaka M., et al. Overexpression of orphan G-protein-coupled receptor, Gpr49, in human hepatocellular carcinomas with beta-catenin mutations. Hepatology 37 (2003) 528-533
15. Laurent-Puig P., Plomteux O., Bluteau O., Zinzindohoue F., Jeannot E., Dahan K., et al. Frequent mutations of hepatocyte nuclear factor 1 in colorectal cancer with microsatellite instability. Gastroenterology 124 (2003) 1311-1314