On-column hydrolysis kinetics determination of boronic pinacol ester intermediates for use in optimization of fast HPLC methods

Journal of Liquid Chromatography and Related Technologies

Volumn 29, Issue 19, 2006, Pages 2795-2806

  Xu, Jing ^a   Duran, D ^a   Mao, Bing ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Boronic acid; Boronic pinacol ester intermediates; On column hydrolysis kinetics

Indexed keywords

ACTIVATION ENERGY; BORON COMPOUNDS; DRUG PRODUCTS; HYDROLYSIS; LIQUID CHROMATOGRAPHY; REACTION KINETICS;

BORONIC ACIDS; BORONIC PINACOL ESTER INTERMEDIATES; REVERSED PHASE LIQUID CHROMATOGRAPHY (RPLC);

ESTERS;

BORONIC ACID DERIVATIVE; ESTER DERIVATIVE; ORGANIC COMPOUND;

ACCURACY; ARTICLE; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; HYDROLYSIS KINETICS; MEDICAL INFORMATION; PH; PINACOL REARRANGEMENT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SUZUKI REACTION; TEMPERATURE ACCLIMATIZATION;

EID: 33750428172     PISSN: 10826076     EISSN: 1520572X     Source Type: Journal    
DOI: 10.1080/10826070600959013     Document Type: Article

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