The 2′-phosphate of NADP is responsible for proper orientation of the nicotinamide ring in the oxidative decarboxylation reaction catalyzed by sheep liver 6-phosphogluconate dehydrogenase

Journal of Biological Chemistry

Volumn 281, Issue 48, 2006, Pages 36803-36810

  Li, Lei ^a   Cook, Paul F ^a  

^a UNIVERSITY OF OKLAHOMA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; CATALYSIS; HYDROGEN BONDS; MOLECULAR BIOLOGY; MUTAGENESIS;

DECARBOXYLATION REACTION; HYDRIDE TRANSFER; MUTANT ENZYMES; NICOTINAMIDE RING;

ENZYME KINETICS;

CARBON 13; NICOTINAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; PHOSPHOGLUCONATE DEHYDROGENASE; POTASSIUM; ASPARAGINE; GLYCOSIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE; OXYGEN; PHOSPHATE; THREONINE;

ARTICLE; CATALYSIS; CONTROLLED STUDY; DECARBOXYLATION; ENZYME BINDING; ENZYME KINETICS; ENZYME MECHANISM; ENZYME SYNTHESIS; NONHUMAN; OXIDATION; PRIORITY JOURNAL; SHEEP; SITE DIRECTED MUTAGENESIS; ANIMAL; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; HUMAN; HYDROGEN BOND; LIVER; METABOLISM;

OVIS ARIES;

ANIMALS; ASPARAGINE; BINDING SITES; GLYCOSIDES; HUMANS; HYDROGEN BONDING; LIVER; MODELS, MOLECULAR; NAD; NADP; NIACINAMIDE; OXYGEN; PHOSPHATES; PHOSPHOGLUCONATE DEHYDROGENASE; SHEEP; THREONINE;

EID: 33750381313     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M604609200     Document Type: Article

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