Single-dose methotrexate regimen in the treatment of low-risk gestational trophoblastic neoplasia

American Journal of Obstetrics and Gynecology

Volumn 195, Issue 5, 2006, Pages 1282-1286

  Chan, Karen K L ^a   Huang, Yong ^a   Tam, Kar Fai ^a   Tse, Ka Yu ^a   Ngan, Hextan Y S ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Chemotherapy; Gestational trophoblastic neoplasia; Methotrexate

Indexed keywords

BLEOMYCIN; CHORIONIC GONADOTROPIN; CYCLOPHOSPHAMIDE; DACTINOMYCIN; ETOPOSIDE; GRANULOCYTE COLONY STIMULATING FACTOR; HYDROXYUREA; METHOTREXATE; VINCRISTINE; VINCRISTINE SULFATE;

ADOLESCENT; ADULT; ALOPECIA; ARTICLE; CANCER CHEMOTHERAPY; CHEMOTHERAPY INDUCED EMESIS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG DOSE REGIMEN; DRUG EFFICACY; DRUG INFUSION; DRUG TREATMENT FAILURE; FEMALE; HORMONE DETERMINATION; HUMAN; MAJOR CLINICAL STUDY; METASTASIS; NEUTROPENIA; OBSERVATIONAL STUDY; PRIORITY JOURNAL; PROSPECTIVE STUDY; SINGLE DRUG DOSE; STEVENS JOHNSON SYNDROME; STOMATITIS; TROPHOBLASTIC TUMOR; TUMOR REGRESSION;

ADOLESCENT; ADULT; ANTIMETABOLITES, ANTINEOPLASTIC; CHORIONIC GONADOTROPIN; COHORT STUDIES; DRUG ADMINISTRATION SCHEDULE; FEMALE; GESTATIONAL TROPHOBLASTIC NEOPLASMS; HUMANS; INJECTIONS, INTRAVENOUS; METHOTREXATE; MIDDLE AGED; PREGNANCY; PROSPECTIVE STUDIES; REMISSION INDUCTION; RETREATMENT; RISK FACTORS; TREATMENT OUTCOME;

EID: 33750378763     PISSN: 00029378     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ajog.2006.03.048     Document Type: Article

References (14)

1. Berkowitz R.S., Goldstein D.P., and Bernstein M.R. Ten year's experience with methotrexate and folic acid as primary therapy for gestational trophoblastic disease. Gynecol Oncol 23 (1986) 111-118
2. Homesley H.D., Blessing J.A., Rettenmaier M., Capizzi R.L., Major F.J., Twiggs L.B., et al. Weekly intramuscular methotrexate for nonmetastatic gestational trophoblastic disease. Obstet Gynecol 72 (1988) 413-418
3. Soper J.T., Clarke-Pearson D.L., Berchuck A., Rodriguez G., and Hammond C.B. Five-day methotrexate for women with metastatic gestational trophoblastic disease. Gynecol Oncol 54 (1994) 76-79
4. Hoffman M.S., Fiorica J.V., Gleeson N.C., Roberts W.S., and Cavanagh D. A single institution experience with weekly intramuscular methotrexate for nonmetastatic gestational trophoblastic disease. Gynecol Oncol 39 (1996) 292-294
5. Smith E.B., Weed J.C., Tyrey L., and Hammond C.B. Treatment of nonmetastatic gestational trophoblastic disease: results of methotrexate alone versus methotrexate-folinic acid. Am J Obstet Gynecol 144 (1982) 88-92
6. Berkowitz R.S., Goldstein D.P., Jones M.A., Marean A.R., and Bernstein M.R. Methotrexate with citrovorum factor rescue- reduced chemotherapy toxicity in the management of gestational trophoblastic neoplasms. Cancer 45 (1980) 423-426
7. Berkowitz R.S., Goldstein D.P., and Bernstein M.R. Methotrexate with citrovorum factor rescue as primary therapy for gestational trophoblastic disease. Cancer 50 (1982) 2024-2027
8. Bagshawe K.D., Dent J., Newlands E.S., Begent R.H., and Rustin G.J. The role of low-dose methotrexate and folinic acid in gestational trophoblastic tumours (GTT). Br J Obstet Gynaecol 96 (1989) 795-802
9. Khan F., Everard J., Ahmed A., Coleman R.E., Aitken M., and Hancock B.W. Low risk persistent gestational trophoblastic disease treated with low dose methotrexate: efficacy, acute and long term effects. Br J Cancer 89 (2003) 2197-2201
10. Berkowitz R.S., Goldstein D.P., and Bernstein M.R. Methotrexate infusion and folinic acid in the primary treatment of non metastatic gestational trophoblastic tumours. Gynecol Oncol 36 (1990) 56-59
11. Wong L.C., Ngan H.Y.S., Cheng D.K.L., and Ng T.Y. Methotrexate infusion in low risk gestational trophoblastic disease. Am J Obstet Gynecol 183 (2000) 1579-1582
12. Garrett A.P., Garner E.O., Goldstein D.P., and Berkowitz R.S. Methotrexate infusion and folinic acid as primary therapy for nonmetastatic and low risk metastatic gestational trophoblastic tumors 15 years of experience. J Reprod Med 47 (2002) 355-361
13. Kohorn E.I. Is lack of response to single-agent chemotherapy in gestational trophoblastic disease associated with dose scheduling or chemotherapy resistance?. Gynecol Oncol 85 (2002) 36-39
14. Schorge J.O., Lea J.S., Farrar D.F., King M.R., Coleman R.L., and Miller D.S. Management of low risk gestational trophoblastic neoplasia in indigent women. J Reprod Med 48 (2003) 780-784