Effects of radiotherapy and chemotherapy on angiogenesis and leukocyte infiltration in rectal cancer

International Journal of Radiation Oncology Biology Physics

Volumn 66, Issue 4, 2006, Pages 1219-1227

  Baeten, Coen I M ^a   Castermans, Karolien ^a   Lammering, Guido ^a   Hillen, Femke ^a   Wouters, Bradly G ^a   Hillen, Harry F P ^a   Griffioen, Arjan W ^a   Baeten, Cornelius G M I ^b  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

adhesion molecule expression; angiogenesis; leukocyte infiltration; Radiotherapy; rectal carcinoma

Indexed keywords

ANGIOGRAPHY; CELLS; CHEMOTHERAPY; HISTOLOGY; IMMUNOLOGY; TUMORS;

ADHESION MOLECULE EXPRESSION; ANGIOGENESIS; LEUKOCYTE INFILTRATION; RECTAL CARCINOMA; RESPONSE TO RADIOTHERAPY (RTX);

RADIOTHERAPY;

BASIC FIBROBLAST GROWTH FACTOR; CAPECITABINE; CELL ADHESION MOLECULE; FLUOROURACIL; MESSENGER RNA;

ADJUVANT CHEMOTHERAPY; ADULT; AGED; ANALYTICAL PARAMETERS; ANGIOGENESIS; ARTICLE; BIOLOGICAL ACTIVITY; CANCER CHEMOTHERAPY; CANCER IMMUNOLOGY; CANCER RADIOTHERAPY; CELL INFILTRATION; CELL PROLIFERATION; CELL STIMULATION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; ENDOTHELIUM CELL; EPITHELIUM CELL; FEMALE; FLOW CYTOMETRY; FREEZING; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; LEUKOCYTE; MALE; MEDICAL DOCUMENTATION; MICROVASCULATURE; MULTIMODALITY CANCER THERAPY; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; RECTUM CANCER; RECTUM MUCOSA; SAMPLE; STATISTICAL SIGNIFICANCE; TREATMENT RESPONSE; TUMOR BIOPSY; TUMOR CELL;

AGED; DRUG THERAPY; FEMALE; HUMANS; LEUKOCYTES; MALE; NEOVASCULARIZATION, PATHOLOGIC; RADIOTHERAPY; RECTAL NEOPLASMS;

EID: 33750378737     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2006.07.1362     Document Type: Article

References (47)

1. Beets-Tan R.G., Beets G.L., Borstlap A.C., et al. Preoperative assessment of local tumor extent in advanced rectal cancer: CT or high-resolution MRI?. Abdom Imaging 25 (2000) 533-541
2. Beets-Tan R.G., Beets G.L., Vliegen R.F., et al. Accuracy of magnetic resonance imaging in prediction of tumour-free resection margin in rectal cancer surgery. Lancet 357 (2001) 497-504
3. Beets-Tan R.G. MRI in rectal cancer: The T stage and circumferential resection margin. Colorectal Dis 5 (2003) 392-395
4. Improved survival with preoperative radiotherapy in resectable rectal cancer. Swedish Rectal Cancer Trial. N Engl J Med 336 (1997) 980-987
5. Kapiteijn E., Marijnen C.A., Nagtegaal I.D., et al. Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer. N Engl J Med 345 (2001) 638-646
6. Marijnen C.A., Nagtegaal I.D., Kapiteijn E., et al. Radiotherapy does not compensate for positive resection margins in rectal cancer patients: Report of a multicenter randomized trial. Int J Radiat Oncol Biol Phys 55 (2003) 1311-1320
7. Nagtegaal I.D., Marijnen C.A., Kranenbarg E.K., van de Velde C.J., and van Krieken J.H. Circumferential margin involvement is still an important predictor of local recurrence in rectal carcinoma: Not one millimeter but two millimeters is the limit. Am J Surg Pathol 26 (2002) 350-357
8. Dunst J., Reese T., Sutter T., et al. Phase I trial evaluating the concurrent combination of radiotherapy and capecitabine in rectal cancer. J Clin Oncol 20 (2002) 3983-3991
9. Cassidy J., Twelves C., Van Cutsem E., et al. First-line oral capecitabine therapy in metastatic colorectal cancer: A favorable safety profile compared with intravenous 5-fluorouracil/leucovorin. Ann Oncol 13 (2002) 566-575
10. Marijnen C.A., Nagtegaal I.D., Mulder-Stapel A.A., et al. High intrinsic apoptosis, but not radiation-induced apoptosis, predicts better survival in rectal carcinoma patients. Int J Radiat Oncol Biol Phys 57 (2003) 434-443
11. Ikeda Y., Ito M., Matsuu M., et al. Expression of ICAM-1 and acute inflammatory cell infiltration in the early phase of radiation colitis in rats. J Radiat Res (Tokyo) 41 (2000) 279-291
12. Chiba T., Ohtani H., Mizoi T., et al. Intraepithelial CD8+ T-cell-count becomes a prognostic factor after a longer follow-up period in human colorectal carcinoma: Possible association with suppression of micrometastasis. Br J Cancer 91 (2004) 1711-1717
13. Abdalla S.A., Behzad F., Bsharah S., et al. Prognostic relevance of microvessel density in colorectal tumours. Oncol Rep 6 (1999) 839-842
14. Bouma-ter Steege J.C., Baeten C.I., Thijssen V.L., et al. Angiogenic profile of breast carcinoma determines leukocyte infiltration. Clin Cancer Res 10 (2004) 7171-7178
15. Dirkx A.E., Oude Egbrink M.G., Kuijpers M.J., et al. Tumor angiogenesis modulates leukocyte-vessel wall interactions in vivo by reducing endothelial adhesion molecule expression. Cancer Res 63 (2003) 2322-2329
16. Hallahan D., Kuchibhotla J., and Wyble C. Cell adhesion molecules mediate radiation-induced leukocyte adhesion to the vascular endothelium. Cancer Res 56 (1996) 5150-5155
17. Wang J.M., Kumar S., van Agthoven A., Kumar P., Pye D., and Hunter R.D. Irradiation induces up-regulation of E9 protein (CD105) in human vascular endothelial cells. Int J Cancer 62 (1995) 791-796
18. Walther M., Kaffenberger W., and Van B.D. Influence of clinically used antioxidants on radiation-induced expression of intercellular cell adhesion molecule-1 on HUVEC. Int J Radiat Biol 75 (1999) 1317-1325
19. Quarmby S., Kumar P., Wang J., et al. Irradiation induces upregulation of CD31 in human endothelial cells. Arterioscler Thromb Vasc Biol 19 (1999) 588-597
20. Molla M., Panes J., Casadevall M., et al. Influence of dose-rate on inflammatory damage and adhesion molecule expression after abdominal radiation in the rat. Int J Radiat Oncol Biol Phys 45 (1999) 1011-1018
21. Molla M., Gironella M., Miquel R., et al. Relative roles of ICAM-1 and VCAM-1 in the pathogenesis of experimental radiation-induced intestinal inflammation. Int J Radiat Oncol Biol Phys 57 (2003) 264-273
22. Kruse J.J., te Poele J.A., Russell N.S., Boersma L.J., and Stewart F.A. Microarray analysis to identify molecular mechanisms of radiation-induced microvascular damage in normal tissues. Int J Radiat Oncol Biol Phys 58 (2004) 420-426
23. Ala A., Dhillon A.P., and Hodgson H.J. Role of cell adhesion molecules in leukocyte recruitment in the liver and gut. Int J Exp Pathol 84 (2003) 1-16
24. Hallahan D.E., and Virudachalam S. Intercellular adhesion molecule 1 knockout abrogates radiation induced pulmonary inflammation. Proc Natl Acad Sci USA 94 (1997) 6432-6437
25. Martinez Leyton I. [Proctitis due to irradiation.]. Rev Med Chil 80 (1952) 429-430
26. Buell M.G., and Harding R.K. Proinflammatory effects of local abdominal irradiation on rat gastrointestinal tract. Dig Dis Sci 34 (1989) 390-399
27. Sedgwick D.M., and Ferguson A. Dose-response studies of depletion and repopulation of rat intestinal mucosal mast cells after irradiation. Int J Radiat Biol 65 (1994) 483-495
28. De Vries A., Holzberger P., Kunc M., and Hengster P. Influence of irradiation on neutrophilic granulocyte function. Cancer 92 (2001) 2444-2450
29. Baeten C.I., Wagstaff J., Verhoeven I.C., et al. Flow cytometric quantification of tumour endothelial cells; An objective alternative for microvessel density assessment. Br J Cancer 87 (2002) 344-347
30. van der Schaft D.W., Hillen F., Pauwels P., et al. Tumor cell plasticity in Ewing sarcoma, an alternative circulatory system stimulated by hypoxia. Cancer Res 65 (2005) 11520-11528
31. Cummings B.J. Symposium on carcinoma of colon and rectum: 3. Radiation therapy in rectal cancer. Can J Surg 21 (1978) 44-46
32. Sischy B., Remington J.H., Sobel S.H., and Savlov E.D. Treatment of carcinoma of the rectum and squamous carcinoma of the anus by combination chemotherapy, radiotherapy and operation. Surg Gynecol Obstet 151 (1980) 369-371
33. Reis Neto J.A., Quilici F.A., Cordeiro F., Ciquini S., and Reis Jr. J.A. Pre-operative radiotherapy in rectal cancer: Evaluation of irradiation effects on cellular undifferentiation and its influence on prognosis. Hepatogastroenterology 46 (1999) 2825-2830
34. Withers H.R., and Haustermans K. Where next with preoperative radiation therapy for rectal cancer?. Int J Radiat Oncol Biol Phys 58 (2004) 597-602
35. Johansson M., Bergenheim A.T., Widmark A., and Henriksson R. Effects of radiotherapy and estramustine on the microvasculature in malignant glioma. Br J Cancer 80 (1999) 142-148
36. Hurwitz H., Fehrenbacher L., Novotny W., et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 350 (2004) 2335-2342
37. Kabbinavar F.F., Hambleton J., Mass R.D., Hurwitz H.I., Bergsland E., and Sarkar S. Combined analysis of efficacy: The addition of bevacizumab to fluorouracil/leucovorin improves survival for patients with metastatic colorectal cancer. J Clin Oncol 23 (2005) 3706-3712
38. Haraldsen G., Kvale D., Lien B., Farstad I.N., and Brandtzaeg P. Cytokine-regulated expression of E-selectin, intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) in human microvascular endothelial cells. J Immunol 156 (1996) 2558-2565
39. Gaugler M.H., Squiban C., van der M.A., Bertho J.M., Vandamme M., and Mouthon M.A. Late and persistent up-regulation of intercellular adhesion molecule-1 (ICAM-1) expression by ionizing radiation in human endothelial cells in vitro. Int J Radiat Biol 72 (1997) 201-209
40. ten Kate M., Hofland L.J., van Grevenstein W.M., van Koetsveld P.V., Jeekel J., and van Eijck C.H. Influence of proinflammatory cytokines on the adhesion of human colon carcinoma cells to lung microvascular endothelium. Int J Cancer 112 (2004) 943-950
41. Kiani M.F., Yuan H., Chen X., Smith L., Gaber M.W., and Goetz D.J. Targeting microparticles to select tissue via radiation-induced upregulation of endothelial cell adhesion molecules. Pharm Res 19 (2002) 1317-1322
42. Prabhakarpandian B., Goetz D.J., Swerlick R.A., Chen X., and Kiani M.F. Expression and functional significance of adhesion molecules on cultured endothelial cells in response to ionizing radiation. Microcirculation 8 (2001) 355-364
43. Panes J., Anderson D.C., Miyasaka M., and Granger D.N. Role of leukocyte-endothelial cell adhesion in radiation-induced microvascular dysfunction in rats. Gastroenterology 108 (1995) 1761-1769
44. Clark W.M., Lauten J.D., Lessov N., Woodward W., and Coull B.M. Time course of ICAM-1 expression and leukocyte subset infiltration in rat forebrain ischemia. Mol Chem Neuropathol 26 (1995) 213-230
45. Nakano O., Sato M., Naito Y., et al. Proliferative activity of intratumoral CD8(+) T-lymphocytes as a prognostic factor in human renal cell carcinoma: clinicopathologic demonstration of antitumor immunity. Cancer Res 61 (2001) 5132-5136
46. Funada Y., Noguchi T., Kikuchi R., Takeno S., Uchida Y., and Gabbert H.E. Prognostic significance of CD8+ T cell and macrophage peritumoral infiltration in colorectal cancer. Oncol Rep 10 (2003) 309-313
47. Golby S.J., Chinyama C., and Spencer J. Proliferation of T-cell subsets that contact tumour cells in colorectal cancer. Clin Exp Immunol 127 (2002) 85-91