A proposed mechanism for amitriptyline neurotoxicity based on its detergent nature

Toxicology and Applied Pharmacology

Volumn 217, Issue 1, 2006, Pages 100-106

  Kitagawa, Norihito ^a   Oda, Mayuko ^b   Nobutaka, I ^b   Satoh, Hidetoshi ^b   Totoki, Tadahide ^b   Morimoto, Masatoshi ^b  

^a Tsuruta Hospital   (Japan)

^b SAGA UNIVERSITY   (Japan)

Author keywords

Amitriptyline; Membrane disruption; Neurotoxic mechanism; Solubilization

Indexed keywords

AMITRIPTYLINE; DETERGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; HEMOLYSIS; HISTOPATHOLOGY; LIPID MEMBRANE; MEMBRANE DAMAGE; NERVE MEMBRANE; NEUROLOGIC DISEASE; NEUROTOXICITY; NONHUMAN; RAT; SAFETY; SOLUBILIZATION; SPINAL ANESTHESIA;

AMITRIPTYLINE; ANESTHETICS, LOCAL; ANIMALS; DETERGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; ERYTHROCYTES; GAIT; HEMOLYSIS; HUMANS; LIGHT; LIPID BILAYERS; MALE; NEUROTOXICITY SYNDROMES; PARALYSIS; PHOSPHATIDYLGLYCEROLS; RATS; RATS, SPRAGUE-DAWLEY; SCATTERING, RADIATION; SENSORY THRESHOLDS; SPINAL NERVES;

ANIMALIA;

EID: 33750341925     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2006.08.003     Document Type: Article

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