Specific and sensitive analysis of nefopam and its main metabolite desmethyl-nefopam in human plasma by liquid chromatography-ion trap tandem mass spectrometry

Journal of Pharmaceutical and Biomedical Analysis

Volumn 42, Issue 5, 2006, Pages 593-600

  Hoizey, Guillaume ^a   Goglin, Anne ^a   Malinovsky, Jean Marc ^b   Robinet, Arnaud ^a   Binet, Laurent ^a   Kaltenbach, Matthieu L ^c   Millart, Hervé ^a   Lamiable, Denis ^a  

^a HÔPITAL MAISON BLANCHE   (France)

^b REIMS UNIVERSITY HOSPITAL   (France)

^c UNIVERSITÉ DE REIMS CHAMPAGNE ARDENNE   (France)

Author keywords

Analgesia; Desmethyl nefopam; Liquid chromatography mass spectrometry; Nefopam

Indexed keywords

ACETONITRILE; DESMETHYLNEFOPAM; DRUG METABOLITE; ETHER; ETHYL LOFLAZEPATE; FORMIC ACID; NEFOPAM; UNCLASSIFIED DRUG;

ACCURACY; ALKALINIZATION; ARTICLE; CALIBRATION; CASE REPORT; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG IDENTIFICATION; DRUG ISOLATION; EFFLUENT; ELECTROSPRAY; FLOW RATE; HUMAN; ION TRAP MASS SPECTROMETRY; IONIZATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETER; PLASMA; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY; TEMPERATURE;

CALIBRATION; CHROMATOGRAPHY, LIQUID; HUMANS; INJECTIONS, INTRAVENOUS; NEFOPAM; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY;

EID: 33750324352     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2006.05.024     Document Type: Article

References (13)

1. Heel R.C., Brodgen R.N., Pakes G.E., Speight T.M., and Avery G.S. Drugs 19 (1980) 249-267
2. Aymard G., Warot D., Demolis P., Giudicelli J.F., Lechat P., Guern M.E., Alquier C., and Diquet B. Pharmacol. Toxicol. 92 (2003) 279-286
3. Chawla J., Le Guern M.E., Alquier C., Kalhorn T.F., and Levy R.H. Ther. Drug Monit. 25 (2003) 203-210
4. Mimoz O., Incagnolin P., Josse C., Gillon M.C., Kulhman L., Mirand A., Soilleux H., and Fletcher D. Anaesthesia 56 (2001) 520-525
5. Mc Lincock T.T., Kenny G.N., Howie J.C., McArdle C.S., Lawrie S., and Aitken H. Br. J. Surg. 75 (1988) 779-781
6. Merle J.C., Vandroux D., Odin I., Dupuis J.L., Mehaddi Y., and Nathan N. Ann. Fr. Anesth. Reanim. 24 (2005) 13-18
7. Schuppan D., Hansen C.S., and Ober R.E. J. Pharm. Sci. 67 (1978) 1720-1723
8. Ehrsson H., and Eksborg S. J. Chromatogr. 136 (1977) 154-158
9. Chang S.F., Hansen C.S., Fox J.M., and Ober R.E. J. Chromatogr. 226 (1981) 79-89
10. Burton L.C., Loftus N.J., Vere D.W., and Whelpton R. J. Chromatogr. B 526 (1990) 159-168
11. Liu D.T., Savage J.M., and Donnell D. Br. J. Clin. Pharmacol. 23 (1987) 99-101
12. Aymard G., Warot D., Demolis P., Laville I., and Diquet B. J. Pharm. Biomed. Anal. 30 (2002) 1013-1021
13. Müller C., Schäfer P., Strörtzel M., Vogt S., and Weinmann W. J. Chromatrogr. B 773 (2002) 47-52