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For a synthesis of an appropriate isocoumarin building block, see: (a) Brasholz, M.; Reissig, H.-U. Synlett 2004, 2736.
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26
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33750356896
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note
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The following protecting groups were tested: TMS, TES, TIPS, TBDMS, TBDPS, THP.
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27
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33750378569
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note
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The trans describes the configuration of the 3′-hydroxy group relative to the C-O bond of the pyran ring. This configuration is also found in natural occurring heliquinomycin.
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28
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33750315594
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For X-ray analyses of compounds trans-27 and trans-28, see: (a) Azap, C.; Luger, P.; Reissig, H.-U.; Wagner, A. Z. Kristallogr. NCS 2004, 219, 492.
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