Ladostigil, a novel multifunctional drug for the treatment of dementia co-morbid with depression

Journal of Neural Transmission, Supplement

Volumn , Issue 70, 2006, Pages 443-446

  Weinstock, M ^a   Luques, L ^a   Bejar, C ^a   Shoham, S ^b  

^a HEBREW UNIVERSITY   (Israel)

^b HERZOG HOSPITAL   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINESTERASE; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; CYTOCHROME C OXIDASE; DONEPEZIL; LADOSTIGIL; MONOAMINE OXIDASE A INHIBITOR; MONOAMINE OXIDASE B INHIBITOR; RASAGILINE; RIVASTIGMINE; STREPTOZOCIN; TYRAMINE;

ASTROCYTE; COMORBIDITY; CONFERENCE PAPER; DEMENTIA; DEPRESSION; DOSE RESPONSE; DRUG ACTIVITY; DRUG MECHANISM; DRUG POTENTIATION; ENZYME INHIBITION; HIPPOCAMPUS; HUMAN; IN VIVO STUDY; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; TRANQUILIZING ACTIVITY;

EID: 33750307382     PISSN: 03036995     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-211-45295-0_67     Document Type: Conference Paper

References (10)

1. Buccafusco JJ, Terry AV, Goren T, et al. (2003) Potential cognitive actions of (N-propargyl-(3R)-aminoindan-5-yl-ethyl methyl carbamate, (TV3326), a novel neuroprotective agent, as assessed in old rhesus monkeys in their performance of versions of a delayed matching task. Neuroscience 119: 669-678
2. Ellis JM (2005) Cholinesterase inhibitors in the treatment of dementia. J Am Osteopath Assoc 105: 145-158
3. Hirai K, Aliev G, Nunomura A, et al. (2001) Mitochondrial abnormalities in Alzheimer's disease. J Neurosci 21: 3017-3302
4. Kaasinen V, Nagren K, Jarvenpaa T, et al. (2002) Regional effects of donepezil and rivastigmine on cortical acetylcholinesterase activity in Alzheimer's disease. J Clin Psychopharmacol 22: 615-620
5. Katsuse O, Iseki E, Kosaka K (2003) Immunohistochemical study of the expression of cytokines and nitric oxide synthase in brains of patients with dementia with Lewy bodies. Neuropathology 23:9-15
6. Poltyrev T, Gorodetsky E, Bejar C, et al. (2005) Effect of chronic treatment with ladostigil (TV-3326), on anxiogenic and depressive-like behaviour and on activity of the hypothalamic pituitary adrenal axis in male and female prenatally-stressed rats. Psychopharmacology 181: 118-125
7. Weinstock M (2001) Alterations induced by gestational stress in brain morphology and behaviour of the offspring. Prog Neurobiol 65: 427-451
8. Weinstock M, Gorodetsky E, Poltyrev T, et al. (2003) A novel cholinesterase and brain-selective monoamine oxidase inhibitor for the treatment of dementia co-morbid with depression and Parkinson's disease. Prog Neuropsychopharmacol Biol Psychiatry 27: 555-561
9. Weinstock M, Shoham S (2004) Rat models of dementia based on reductions in regional glucose metabolism, cerebral blood flow and cytochrome oxidase activity. J Neural Transm 111: 347-366
10. Youdim MBH, Weinstock M (2001) Molecular basis of neuroprotective activities of rasagiline and the anti-Alzheimer drug, TV3326 [(N-propargyl-(3R) aminoindan-5-YL)-ethyl methyl carbamate]. Cell Mol Neurobiol 21: 555-573