Neuronal damage in rat brain and spinal cord after cardiac arrest and massive hemorrhagic shock

Critical Care Medicine

Volumn 34, Issue 11, 2006, Pages 2820-2826

  Kudo, Yoshifumi ^a   Ohtaki, Hirokazu ^a,b   Dohi, Kenji ^a   Yin, Li ^a   Nakamachi, Tomoya ^a   Endo, Sakura ^a   Yofu, Sachiko ^a   Hiraizumi, Yutaka ^a   Miyaoka, Hideyo ^a   Shioda, Seiji ^a,b  

^a SHOWA UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Cardiac arrest; Demyelination; Global ischemia; Necrotic neuronal cell death; Paraplegia; Spinal cord injury

Indexed keywords

DEOXYURIDINE TRIPHOSPHATE PYROPHOSPHATASE; DNA NUCLEOTIDYLEXOTRANSFERASE; EOSIN; FLUORESCENT DYE; FLUORO JADE B; HEMATOXYLIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN DAMAGE; BRAIN REGION; CELL DEATH; COMPUTER PROGRAM; CONTROLLED STUDY; DEMYELINATION; DISEASE SEVERITY; ELECTRON MICROSCOPY; GLOBAL ISCHEMIA; GRAY MATTER; HEART ARREST; HEMORRHAGIC SHOCK; HIPPOCAMPUS; HISTOLOGY; IMAGE ANALYSIS; ISCHEMIA; LIMB; LUMBAR SPINAL CORD; MALE; MOTOR DYSFUNCTION; NERVE CELL LESION; NICK END LABELING; NONHUMAN; PARALYSIS; PARAPLEGIA; PRIORITY JOURNAL; RAT; RESUSCITATION; SPINAL CORD DORSAL HORN; SPINAL CORD LESION; STRUCTURE ANALYSIS; ULTRASTRUCTURE; WHITE MATTER;

ANIMALS; CELL DEATH; DEMYELINATING DISEASES; DISEASE MODELS, ANIMAL; HEART ARREST; HINDLIMB; HIPPOCAMPUS; HYPOXIA, BRAIN; LUMBAR VERTEBRAE; MALE; MOTOR SKILLS; NECROSIS; NEURONS; PARAPLEGIA; RATS; RATS, SPRAGUE-DAWLEY; SHOCK, HEMORRHAGIC; SPINAL CORD ISCHEMIA;

EID: 33750257496     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.CCM.0000242522.48734.64     Document Type: Article

References (37)

1. Bunch TJ, White RD, Gersh BJ, et al: Longterm outcomes of out-of-hospital cardiac arrest after successful early defibrillation. N Engl J Med 2003; 348:2626-2633
2. Hypothermia After Cardiac Arrest Group: Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med 2002; 346:549-556
3. Paradis NA, Wenzel V, Southall J: Pressor drugs in the treatment of cardiac arrest. Cardiol Clin 2002; 20:61-78
4. de Vos R, de Haes HC, Koster RW, et al: Quality of survival after cardiopulmonary resuscitation. Arch Intern Med 1999; 159:249-254
5. Neigh GN, Kofler J, Meyers JL, et al: Cardiac arrest/cardiopulmonary resuscitation increases anxiety-like behavior and decreases social interaction. J Cereb Blood Flow Metab 2004; 24:372-382
6. Kim SW, Kim RC, Choi BH, et al: Nontraumatic ischemic myelopathy: A review of 25 cases. Paraplegia 1988; 26:262-272
7. Imaizumi H, Ujike Y, Asai Y, et al: Spinal cord ischemia after cardiac arrest. J Emerg Med 1994; 12:789-793
8. Duggal N, Lach B: Selective vulnerability of the lumbosacral spinal cord after cardiac arrest and hypotension. Stroke 2002; 33:116-121
9. Auer RN, Benveniste H: Hypoxia and related conditions. In: Greenfield's Neuropathology. Sixth Edition. Graham DI, Lantos PL (Eds). New York, Oxford University Press, 1998, pp 262-314
10. Garcia JH: Morphology of global cerebral ischemia. Crit Care Med 1988; 16:979-987
11. Petito CK, Feldmann E, Pulsinelli WA, et al: Delayed hippocampal damage in humans following cardiorespiratory arrest. Neurology 1987; 37:1281-1286
12. Cheshire WP, Santos CC, Massey EW, et al: Spinal cord infarction: Etiology and outcome. Neurology 1996; 47:321-330
13. Gilles FH, Nag D: Vulnerability of human spinal cord in transient cardiac arrest. Neurology 1971; 21:833-839
14. Azzarelli B, Roessmann U: Diffuse "anoxic" myelopathy. Neurology 1977; 27:1049-1052
15. Davidson MT, Deitch EA, Lu Q, et al: A study of the biologic activity of trauma-hemorrhagic shock mesenteric lymph over time and relative role of cytokines. Surgery 2004; 136:32-41
16. Takasu A, Prueckner S, Tisherman SA, et al: Effect of increased oxygen breathing in a volume controlled hemorrhagic shock outcome model in rats. Resuscitation 2000; 45:209-220
17. Reid KH, Young C, Schurr A, et al: Audiogenic seizures following global ischemia induced by chest compression in Long-Evans rats. Epilepsy Res 1996; 23:195-209
18. Reid KH, Paskitti M, Guo SZ, et al: Experience with ketamine and sodium pentobarbital as anesthetics in a rat model of cardiac arrest and resuscitation. Resuscitation 2003; 57:201-210
19. Marsala M, Yaksh TY: Transient spinal ischemia in the rat: Characterization of behavioral and histopathological consequences as a function of the duration of aortic occlusion. J Cereb Blood Flow Metab 1994; 14:526-535
20. Schmued LC, Albertson C, Slikker W Jr, et al: Fluoro-Jade: A novel fluorochrome for the sensitive and reliable histochemical localization of neuronal degeneration. Brain Res 1997; 751:37-46
21. Schmued LC, Hopkins KJ: Fluoro-Jade B: A high affinity fluorescent marker for the localization of neuronal degeneration. Brain Res 2000; 874:123-130
22. Matsunaga M, Ohtaki H, Takaki A, et al: Nucleoprotamine diet derived from salmon soft roe protects mouse hippocampal neurons from delayed cell death after transient forebrain ischemia. Neurosci Res 2003; 47:269-276
23. Xu YH, Pitot HC: Building quantitative stereology data files with Scion image, a public domain image processing and analysis software. Comput Methods Programs Biomed 1999; 59:131-142
24. Ohtaki H, Endo S, Nakamachi T: Increased expression of intercellular adhesion molecule-1 (ICAM-1) in mouse brain following transient cerebral ischemia. Acta Histchem Cytochem 2003; 36:385-391
25. Kirino T, Sano K: Selective vulnerability in the gerbil hippocampus following transient ischemia. Acta Neuropathol 1984; 62:201-208
26. Nitatori T, Sato N, Waguri Y, et al: Delayed neuronal death in the CA1 pyramidal cell layer of the gerbil hippocampus following transient ischemia is apoptosis. J Neurosci 1995; 15:1001-1011
27. Dohi K, Shioda S, Mizushima H: Delayed neuronal cell death and microglial cell reactivity in the CA1 region of the rat hippocampus in the cardiac arrest model. Med Electron Microsc 1998; 31:85-93
28. Garcia JH, Liu KF, Ho KL: Neuronal necrosis after middle cerebral artery occulusion in Wistar rats progresses at different time intervals in the caudoputamen and the cortex. Stroke 1995; 26:636-643
29. Kato H, Kanellopoulos GK, Matuo S, et al: Neuronal apoptosis and necrosis following spinal cord ischemia in the rat. Exp Neurol 1997; 148:464-474
30. Lazdunski LL, Matsushita K, Hirt L, et al: Spinal cord ischemia: Development of a model in the mouse. Stroke 2000; 31:208-213
31. Follis F, Scremin OU, Blisard KS, et al: Selective vulnerability of white matter during spinal cord ischemia. J Cereb Blood Flow Metab 1993; 13:170-178
32. Kanellopoulos GK, Xu XM, Hsu CY, et al: White matter injury in spinal cord ischemia: Protection by AMPA/kainate glutamate receptor antagonism. Stroke 2000; 31:1945-1952
33. Knellopoulos GK, Kato H, Chung Y, et al: Spinal cord ischemic injury: Development of a new model in the rat. Stroke 1997; 28:2532-2538
34. Lu K, Liang CL, Chen HJ: Injury severity and cell death mechanisms: Effect of concomitant hypovolemic hypotension on spinal cord ischemia-reperfusion in rats. Exp Neurol 2004; 185:120-132
35. Laurence K, Uwe E, Peter S, et al: Outcome model of asphyxial cardiac arrest in rats. J Cereb Blood Flow Metab 1995; 15:1032-1039
36. Krep H, Brinker G, Schwindt W, et al: Endothelin type A-antagonist improves long-term neurological recovery after cardiac arrest in rats. Crit Care Med 2000; 28:2873-2880
37. Kofler J, Hattori K, Sawada M, et al: Histopathological and behavioral characterization of a novel model of cardiac arrest and cardiopulmonary resuscitation. J Neurosci Methods 2004; 136:33-44