Novel pan-DR-binding T cell epitopes of adenovirus induce pro-inflammatory cytokines and chemokines in healthy donors

International Immunology

Volumn 18, Issue 11, 2006, Pages 1521-1529

  Haveman, Lianne M ^a,b   Bierings, Marc ^a   Legger, Elisabeth ^a   Klein, Mark R ^a,b   de Jager, Wilco ^a,b   Otten, Henny G ^c   Albani, Salvatore ^b,d,e   Kuis, Wietse ^a   Sette, Alessandro ^f   Prakken, Berent J ^a,b  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^d Androclus Therapeutics   (Italy)

^e UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^f LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; CYTOKINE; DNA DIRECTED DNA POLYMERASE; E1B PROTEIN; EPITOPE; HLA DR ANTIGEN; PEPTIDE; VIRUS PROTEIN;

ADENOVIRUS; ADOPTIVE IMMUNOTHERAPY; ADULT; ALGORITHM; ALLELE; ANTIGEN BINDING; ARTICLE; BINDING ASSAY; CELL ISOLATION; CONTROLLED STUDY; FATALITY; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; IMMUNOASSAY; IN VITRO STUDY; INFLAMMATION; LYMPHOCYTE PROLIFERATION; NORMAL HUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PREDICTION; PRIORITY JOURNAL; SEROTYPE; T LYMPHOCYTE; VIRUS INFECTION;

ADENOVIRIDAE; ALGORITHMS; AMINO ACID SEQUENCE; CELL PROLIFERATION; CELLS, CULTURED; CHEMOKINES; CYTOKINES; DNA-BINDING PROTEINS; EPITOPES, T-LYMPHOCYTE; HLA-DR ANTIGENS; HUMANS; IMMUNOASSAY; LEUKOCYTES, MONONUCLEAR; MOLECULAR SEQUENCE DATA; T-LYMPHOCYTES;

EID: 33750214383     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxl085     Document Type: Article

References (25)

1. La Rosa, A. M., Champlin, R. E., Mirza, N. et al. 2001. Adenovirus infections in adult recipients of blood and marrow transplants. Clin. Infect. Dis. 32:871.
2. Runde, V., Ross, S., Trenschel, R. et al. 2001. Adenoviral infection after allogeneic stem cell transplantation (SCT): Report on 130 patients from a single SCT unit involved in a prospective multi center surveillance study. Bone Marrow Transplant. 28:51.
3. Howard, D. S., Phillips, G. L., II, Reece, D. E. et al. 1999. Adenovirus infections in hematopoietic stem cell transplant recipients. Clin. Infect. Dis. 29:1494.
4. Baldwin, A., Kingman, H., Darville, M. et al. 2000. Outcome and clinical course of 100 patients with adenovirus infection following bone marrow transplantation. Bone Marrow Transplant. 26:1333.
5. Munoz, F. M., Piedra, P. A., Demmler, G. J. 1998. Disseminated adenovirus disease in immuno-compromised and immunocompetent children. Clin. Infect. Dis. 27:1194.
6. Einsele, H. 2003. Antigen-specific T cells for the treatment of infections after transplantation. Hematol. J. 4:10.
7. Einsele, H., Roosnek, E., Rufer, N. et al. 2002. Infusion of cytomegalovirus (CMV)-specific T cells for the treatment of CMV infection not responding to antiviral chemotherapy. Blood 99:3916.
8. Walter, E. A., Greenberg, P. D., Gilbert, M. J. et al. 1995. Reconstitution of cellular immunity against cytomegalovirus in recipients of allogeneic bone marrow by transfer of T-cell clones from the donor. N. Engl. J. Med. 333:1038.
9. Flomenberg, P., Piaskowski, V., Truitt, R. L., Casper, J. T. 1995. Characterization of human proliferative T cell responses to adenovirus. J. Infect. Dis. 171:1090.
10. Olive, M., Eisenlohr, L., Flomenberg, N., Hsu, S., Flomenberg, P. 2002. The adenovirus capsid protein hexon contains a highly conserved human CD4+ T-cell epitope. Hum. Gene Ther. 13:1167.
11. Liebermann, H., Lotz, K., Seidel, W. 2002. Mapping of epitopes on the fiber knobs of human adenovirus serotypes 8 and 15. Intervirology 45:59.
12. Leen, A. M., Sili, U., Vanin, E. F. et al. 2004. Conserved CTL epitopes on the adenovirus hexon protein expand subgroup cross-reactive and subgroup-specific CD8+ T cells. Blood 20:1011.
13. Heemskerk, B., Veltrop-Duits, L. A., van Vreeswijk, T. et al. 2003. Extensive cross-reactivity of CD4+ adenovirus-specific T cells: implications for immunotherapy and gene therapy. J. Virol. 77: 6562.
14. Smith, C. A., Woodruff, L. S., Rooney, C., Kitchingman, G. R. 1998. Extensive cross-reactivity of adenovirus-specific cytotoxic T cells. Hum. Gene Ther. 9:1419.
15. Sette, A. 2000. Tools of the trade in vaccine design. Science 290:2074.
16. Southwood, S., Sidney, J., Kondo, A. et al. 1998. Several common HLA-DR types share largely overlapping peptide binding repertoires. J. Immunol. 160:3363.
17. Kamphuis, S., Kuis, W., de Jager, W. et al. 2005. Tolerogenic immune responses to novel T-cell epitopes fromheat-shock protein 60 in juvenile idiopathic arthritis. Lancet 366:50.
18. van der Zee, R., Wauben, M. H. M., Lots, T. H. A., Van Eden, W. 1992. Simultaneous multiple peptide synthesis (SMPS) for the analysis of T cell epitopes. J. Cell. Biochem. 16D:83.
19. Vignali, D. A. 2000. Multiplexed particle-based flow cytometric assays. J. Immunol. Methods 243:243.
20. De Jager, W., te Velthuis, H., Prakken, B. J., Kuis, W., Rijkers, G. T. 2003. Simultaneous detection of 15 human cytokines in a single sample of stimulated peripheral blood mononuclear cells. Clin. Diagn. Lab. Immunol. 10:133.
21. Khan, S. S., Smith, M. S., Reda, D., Suffredini, A. F., McCoy, J. P., Jr. 2004. Multiplex bead array assays for detection of soluble cytokines: Comparisons of sensitivity and quantitative values among kits from multiple manufacturers. Cytometry 61B.1:35.
22. Schagen, F. H., Moor, A. C., Cheong, S. C. et al. 1999. Photodynamic treatment of adenoviral vectors with visible light: An easy and convenient method for viral inactivation. Gene Ther. 6:873.
23. Feuchtinger, T., Lücke, J., Hamprecht, K., et al. 2005. Detection of adenovirus-specific T cells in children with adenovirus infection after allogeneic stem cell transplantation. Br. J. Haematol. 128:503.
24. Tang, J., Olive, M., Champagne, K. et al. 2004. Adenovirus hexon T-cell epitope is recognized by most adults and is restricted by HLA DP4, the most common class II allele. Gene Ther. 22:1.
25. Anderson, B. E., McNiff, J., Yan, J. et al. 2003. Memory CD4+ Tcells do not induce graft-versus-host disease. J. Clin. Invest. 112:101.