No effect of anti-interleukin-5 therapy (mepolizumab) on the atopy patch test in atopic dermatitis patients

International Archives of Allergy and Immunology

Volumn 141, Issue 3, 2006, Pages 290-294

  Oldhoff, J M ^a   Darsow, U ^b   Werfel, T ^c   Bihari, I C ^a   Katzer, K ^b   Laifaoui, J ^b   Plotz S ^b   Kapp, A ^c   Knol, E F ^a   Bruijnzeel Koomen, C A F M ^a   Ring, J ^b   De Bruin Weller, M S ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Anti interleukin 5 antibody; Atopic dermatitis; Atopy patch test; Eosinophils; Mepolizumab; Skin biopsies

Indexed keywords

ALLERGEN; MEPOLIZUMAB; PLACEBO;

ADULT; ARTICLE; ATOPIC DERMATITIS; ATOPY PATCH TEST; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; ECZEMA; EOSINOPHIL COUNT; EVALUATION; FEMALE; HUMAN; HUMAN TISSUE; IN VIVO STUDY; MALE; MULTICENTER STUDY; OUTCOME ASSESSMENT; PATCH TEST; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SKIN BIOPSY; TREATMENT OUTCOME;

ADULT; ANTIBODIES, MONOCLONAL; CELL COUNT; DERMATITIS, ATOPIC; EOSINOPHILS; FEMALE; HUMANS; INTERLEUKIN-5; MALE; MIDDLE AGED; PATCH TESTS; TREATMENT FAILURE;

EID: 33750193378     PISSN: 10182438     EISSN: None     Source Type: Journal    
DOI: 10.1159/000095299     Document Type: Article

References (19)

1. Leung DY, Bieber T: Atopic dermatitis. Lancet 2003;361:151-160.
2. Ruzicka T, Ring J, Przybilla B: Handbook of Atopic Eczema. Berlin, Springer, 1991.
3. Ring J, Darsow U, Jakob T, Behrendt H: Eczema and dermatitis. ACI International 2005;17:19-25.
4. Leiferman KM: A role for eosinophils in atopic dermatitis. J Am Acad Dermatol 2001;45(suppl 1):S21-S24.
5. Sanderson CJ: Interleukin-5, eosinophils, and disease. Blood 1992;79:3101-3109.
6. Collins PD, Marleau S, Griffiths-Johnson DA, Jose PJ, Williams TJ: Cooperation between interleukin-5 and the chemokine eotaxin to induce eosinophil accumulation in vivo. J Exp Med 1995;182:1169-1174.
7. Warringa RA, Mengelers HJ, Kuijper PH, Raaijmakers JA, Bruijnzeel PL, Koenderman L: In vivo priming of platelet-activating factor-induced eosinophil chemotaxis in allergic asthmatic individuals. Blood 1992;79:1836-1841.
8. Oldhoff JM, Darsow U, Werfel T, Katzer K, Wulf A, Laifaoui J, et al: Anti-IL-5 recombinant humanized monoclonal antibody (mepolizumab) for the treatment of atopic dermatitis. Allergy 2005;60:693-696.
9. Ring J, Darsow U, Gfesser M, Vieluf D: The 'atopy patch test' in evaluating the role of aeroallergens in atopic eczema. Int Arch Allergy Immunol 1997;113:379-383.
10. Bruin-Weller MS, Knol EF, Bruijnzeel-Koomen CA: Atopy patch testing - a diagnostic tool? Allergy 1999;54:784-791.
11. Langeveld-Wildschut EG, Riedl H, Thepen T, Bihari IC, Bruijnzeel PLB, Bruijnzeel-Koomen CAFM: Modulation of the atopy patch test reaction by topical corticosteroids and tar. J Allergy Clin Immunol 2000;106:737-743.
12. Bruynzeel-Koomen CA, Van Wichen DF, Spry CJ, Venge P, Bruynzeel PL: Active participation of eosinophils in patch test reactions to inhalant allergens in patients with atopic dermatitis. Br J Dermatol 1988;118:229-238.
13. Thepen T, Langeveld-Wildschut EG, Bihari IC, Van Wichen DF, Van Reijsen FC, Mudde GC, et al: Biphasic response against aeroallergen in atopic dermatitis showing a switch from an initial TH2 response to a TH1 response in situ: an immunocytochemical study. J Allergy Clin Immunol 1996;97:828-837.
14. Walker C, Kagi MK, Ingold P, Braun P, Blaser K, Bruijnzeel-Koomen CA, et al: Atopic dermatitis: correlation of peripheral blood T cell activation, eosinophilia and serum factors with clinical severity. Clin Exp Allergy 1993;23:145-153.
15. Darsow U, Laifaoui J, Kerschenlohr K, Wollenberg A, Przybilla B, Wuthrich B, et al: The prevalence of positive reactions in the atopy patch test with aeroallergens and food allergens in subjects with atopic eczema: a European multicenter study. Allergy 2004;59:1318-1325.
16. Ying S, Meng Q, Smith SJ, Larché M, Robinson DS, Kay AB: Methods for identifying human eosinophils in blood and tissue. ACI International 2002;14:64-71.
17. Tai PC, Spry CJ, Peterson C, Venge P, Olsson I: Monoclonal antibodies distinguish between storage and secreted forms of eosinophil cationic protein. Nature 1984;309:182-184.
18. Flood-Page PT, Menzies-Gow AN, Kay AB, Robinson DS: Eosinophil's role remains uncertain as anti-interleukin-5 only partially depletes numbers in asthmatic airway. Am J Respir Crit Care Med 2003;167:199-204.
19. Elsner J, Forssmann U: Another renaissance of eosinophils in allergic diseases. ACI International 2002;14:151-155.